MLLT3 — 67 ClinVar variants
All ClinVar germline MLLT3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Benign · 9 Likely benign · 57 Uncertain significance
Full MLLT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MLLT3 p.Arg404Lys Uncertain significance Single submitter
- MLLT3 p.Arg441Gly Uncertain significance Single submitter
- MLLT3 p.Arg443Cys Uncertain significance Single submitter
- MLLT3 p.Asn362Ser Uncertain significance Single submitter
- MLLT3 p.Asn474Ser Uncertain significance Single submitter
- MLLT3 p.Asp409Gly Uncertain significance Single submitter
- MLLT3 p.Asp424Gly Uncertain significance Single submitter
- MLLT3 p.Cys499Tyr Uncertain significance Single submitter
- MLLT3 p.Glu262Val Uncertain significance Single submitter
- MLLT3 p.Glu367Asp Uncertain significance Single submitter
- MLLT3 p.Gly439Ser Uncertain significance Single submitter
- MLLT3 p.His332Pro Uncertain significance Single submitter
- MLLT3 p.His411Arg Uncertain significance Single submitter
- MLLT3 p.His463Arg Uncertain significance Single submitter
- MLLT3 p.His463Tyr Uncertain significance Single submitter
- MLLT3 p.Ile327Met Uncertain significance Single submitter
- MLLT3 p.Ile406Val Uncertain significance Single submitter
- MLLT3 p.Ile485Val Uncertain significance Single submitter
- MLLT3 p.Leu242Val Uncertain significance Single submitter
- MLLT3 p.Leu479Ile Uncertain significance Single submitter
- MLLT3 p.Lys246Asn Uncertain significance Single submitter
- MLLT3 p.Lys373Arg Uncertain significance Single submitter
- MLLT3 p.Lys489Arg Uncertain significance Single submitter
- MLLT3 p.Lys552Arg Uncertain significance Single submitter
- MLLT3 p.Met200Lys Uncertain significance Single submitter
- MLLT3 p.Pro265Ser Uncertain significance Single submitter
- MLLT3 p.Pro285Gln Uncertain significance Single submitter
- MLLT3 p.Pro285Leu Uncertain significance Single submitter
- MLLT3 p.Pro353Leu Uncertain significance Single submitter
- MLLT3 p.Pro381Ala Uncertain significance Single submitter
- MLLT3 p.Pro434Leu Uncertain significance Single submitter
- MLLT3 p.Pro461Ser Uncertain significance Single submitter
- MLLT3 p.Pro461Thr Uncertain significance Single submitter
- MLLT3 p.Pro467Thr Uncertain significance Single submitter
- MLLT3 p.Pro469Ala Uncertain significance Single submitter
- MLLT3 p.Ser228Tyr Uncertain significance Single submitter
- MLLT3 p.Ser232Phe Uncertain significance Single submitter
- MLLT3 p.Ser294Leu Uncertain significance Single submitter
- MLLT3 p.Ser312Gly Uncertain significance Single submitter
- MLLT3 p.Ser345Pro Uncertain significance Single submitter
- MLLT3 p.Ser387Thr Uncertain significance Single submitter
- MLLT3 p.Ser405Tyr Uncertain significance Single submitter
- MLLT3 p.Ser457Cys Uncertain significance Single submitter
- MLLT3 p.Ser483Asn Uncertain significance Single submitter
- MLLT3 p.Thr351Ala Uncertain significance Single submitter
- MLLT3 p.Thr351Met Uncertain significance Single submitter
- MLLT3 p.Thr567Ala Uncertain significance Single submitter
- MLLT3 p.Val338Gly Uncertain significance Single submitter
- MLLT3 p.Val422Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All MLLT3 variants
Benign 1
- p.Ser156= Multiple submitters
Likely benign 9
Uncertain significance 57
- p.Arg404Lys Single submitter ⚠
- p.Arg441Gly Single submitter ⚠
- p.Arg443Cys Single submitter ⚠
- p.Asn362Ser Single submitter ⚠
- p.Asn474Ser Single submitter ⚠
- p.Asp409Gly Single submitter ⚠
- p.Asp424Gly Single submitter ⚠
- p.Cys499Tyr Single submitter ⚠
- p.Glu262Val Single submitter ⚠
- p.Glu367Asp Single submitter ⚠
- p.Gly439Ser Single submitter ⚠
- p.His332Pro Single submitter ⚠
- p.His411Arg Single submitter ⚠
- p.His463Arg Single submitter ⚠
- p.His463Tyr Single submitter ⚠
- p.Ile327Met Single submitter ⚠
- p.Ile406Val Single submitter ⚠
- p.Ile485Val Single submitter ⚠
- p.Leu242Val Single submitter ⚠
- p.Leu479Ile Single submitter ⚠
- p.Lys246Asn Single submitter ⚠
- p.Lys373Arg Single submitter ⚠
- p.Lys489Arg Single submitter ⚠
- p.Lys552Arg Single submitter ⚠
- p.Met200Lys Single submitter ⚠
- p.Met335fs Single submitter
- p.Pro265Ser Single submitter ⚠
- p.Pro285Gln Single submitter ⚠
- p.Pro285Leu Single submitter ⚠
- p.Pro353Leu Single submitter ⚠
- p.Pro381Ala Single submitter ⚠
- p.Pro434Leu Single submitter ⚠
- p.Pro461Ser Single submitter ⚠
- p.Pro461Thr Single submitter ⚠
- p.Pro467Thr Single submitter ⚠
- p.Pro469Ala Single submitter ⚠
- p.Ser153Asn Single submitter ⚠
- p.Ser163Arg Single submitter ⚠
- p.Ser179Asn Single submitter ⚠
- p.Ser180Thr Single submitter ⚠
- p.Ser188Arg Single submitter ⚠
- p.Ser228Tyr Single submitter ⚠
- p.Ser232Phe Single submitter ⚠
- p.Ser288Ter Single submitter
- p.Ser294Leu Single submitter ⚠
- p.Ser312Gly Single submitter ⚠
- p.Ser345Pro Single submitter ⚠
- p.Ser387Thr Single submitter ⚠
- p.Ser405Tyr Single submitter ⚠
- p.Ser457Cys Single submitter ⚠
- p.Ser483Asn Single submitter ⚠
- p.Thr351Ala Single submitter ⚠
- p.Thr351Met Single submitter ⚠
- p.Thr567Ala Single submitter ⚠
- p.Val338Gly Single submitter ⚠
- p.Val422Met Single submitter ⚠
- p.Val508Ile Single submitter