MLN — 17 ClinVar variants
All ClinVar germline MLN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
17 Uncertain significance
Full MLN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MLN p.Ala9Val Uncertain significance Single submitter
- MLN p.Arg43Trp Uncertain significance Single submitter
- MLN p.Gln47Arg Uncertain significance Single submitter
- MLN p.Glu75Gly Uncertain significance Single submitter
- MLN p.Gly103Arg Uncertain significance Single submitter
- MLN p.Ile69Asn Uncertain significance Single submitter
- MLN p.Leu94Val Uncertain significance Single submitter
- MLN p.Met87Arg Uncertain significance Single submitter
- MLN p.Pro68Thr Uncertain significance Single submitter
- MLN p.Pro98Leu Uncertain significance Single submitter
- MLN p.Ser91Pro Uncertain significance Single submitter
- MLN p.Val15Ile Uncertain significance Single submitter
- MLN p.Val27Ile Uncertain significance Single submitter
- MLN p.Val2Leu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All MLN variants
Uncertain significance 17
- p.Ala9Val Single submitter ⚠
- p.Arg43Trp Single submitter ⚠
- p.Gln47Arg Single submitter ⚠
- p.Glu75Gly Single submitter ⚠
- p.Gly103Arg Single submitter ⚠
- p.Ile69Asn Single submitter ⚠
- p.Leu11Gln Single submitter
- p.Leu79Pro Single submitter ⚠
- p.Leu94Val Single submitter ⚠
- p.Met87Arg Single submitter ⚠
- p.Phe26Leu Single submitter ⚠
- p.Pro68Thr Single submitter ⚠
- p.Pro98Leu Single submitter ⚠
- p.Ser91Pro Single submitter ⚠
- p.Val15Ile Single submitter ⚠
- p.Val27Ile Single submitter ⚠
- p.Val2Leu Single submitter ⚠