MLNR — 62 ClinVar variants
All ClinVar germline MLNR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
3 Likely benign · 59 Uncertain significance
Full MLNR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MLNR p.Ala164Thr Uncertain significance Single submitter
- MLNR p.Ala198Pro Uncertain significance Single submitter
- MLNR p.Ala229Val Uncertain significance Single submitter
- MLNR p.Ala406Thr Uncertain significance Single submitter
- MLNR p.Arg102Trp Uncertain significance Single submitter
- MLNR p.Arg136Leu Uncertain significance Single submitter
- MLNR p.Arg136Ser Uncertain significance Single submitter
- MLNR p.Arg142Cys Uncertain significance Single submitter
- MLNR p.Arg145Ser Uncertain significance Single submitter
- MLNR p.Arg15Pro Uncertain significance Single submitter
- MLNR p.Arg236Pro Uncertain significance Single submitter
- MLNR p.Arg236Trp Uncertain significance Single submitter
- MLNR p.Arg378Gly Uncertain significance Single submitter
- MLNR p.Arg384Lys Uncertain significance Single submitter
- MLNR p.Arg97Cys Uncertain significance Single submitter
- MLNR p.Asp84His Uncertain significance Single submitter
- MLNR p.Cys310Arg Uncertain significance Single submitter
- MLNR p.Glu223Gln Uncertain significance Single submitter
- MLNR p.Glu27Gln Uncertain significance Single submitter
- MLNR p.Gly13Arg Uncertain significance Single submitter
- MLNR p.Gly292Ser Uncertain significance Single submitter
- MLNR p.Gly396Arg Uncertain significance Single submitter
- MLNR p.Ile350Val Uncertain significance Single submitter
- MLNR p.Ile358Phe Uncertain significance Single submitter
- MLNR p.Leu202Phe Uncertain significance Single submitter
- MLNR p.Leu369Met Uncertain significance Single submitter
- MLNR p.Leu86Phe Uncertain significance Single submitter
- MLNR p.Met129Arg Uncertain significance Single submitter
- MLNR p.Pro17Ser Uncertain significance Single submitter
- MLNR p.Pro216Arg Uncertain significance Single submitter
- MLNR p.Ser200Leu Uncertain significance Single submitter
- MLNR p.Ser204Trp Uncertain significance Single submitter
- MLNR p.Ser205Leu Uncertain significance Single submitter
- MLNR p.Ser211Ala Uncertain significance Single submitter
- MLNR p.Ser217Pro Uncertain significance Single submitter
- MLNR p.Ser232Thr Uncertain significance Single submitter
- MLNR p.Ser277Arg Uncertain significance Single submitter
- MLNR p.Ser31Leu Uncertain significance Single submitter
- MLNR p.Thr296Ile Uncertain significance Single submitter
- MLNR p.Val188Ala Uncertain significance Single submitter
- MLNR p.Val188Ile Uncertain significance Single submitter
- MLNR p.Val247Ile Uncertain significance Single submitter
- MLNR p.Val251Phe Uncertain significance Single submitter
- MLNR p.Val316Ala Uncertain significance Single submitter
- MLNR p.Val50Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- MLNR p.Ala364Pro Uncertain significance Single submitter
- MLNR p.Arg112Gly Uncertain significance Single submitter
- MLNR p.Arg112His Uncertain significance Single submitter
- MLNR p.Arg67Trp Uncertain significance Single submitter
- MLNR p.Asn74Ile Uncertain significance Single submitter
- MLNR p.Gly271Arg Uncertain significance Single submitter
- MLNR p.Gly90Arg Uncertain significance Single submitter
- MLNR p.Pro103Ser Uncertain significance Single submitter
- MLNR p.Pro237Arg Uncertain significance Single submitter
- MLNR p.Pro280Leu Uncertain significance Single submitter
- MLNR p.Thr194Asn Uncertain significance Single submitter
- MLNR p.Tyr123Ser Uncertain significance Single submitter
- MLNR p.Val304Ala Uncertain significance Single submitter
All MLNR variants
Likely benign 3
- p.Arg278Gln Single submitter
- p.Ser276Arg Single submitter
- p.Ser327= Single submitter
Uncertain significance 59
- p.Ala164Thr Single submitter ⚠
- p.Ala198Pro Single submitter ⚠
- p.Ala229Val Single submitter ⚠
- p.Ala364Pro Single submitter ⚠
- p.Ala406Thr Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg112Gly Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg136Leu Single submitter ⚠
- p.Arg136Ser Single submitter ⚠
- p.Arg142Cys Single submitter ⚠
- p.Arg145Ser Single submitter ⚠
- p.Arg15Pro Single submitter ⚠
- p.Arg236Pro Single submitter ⚠
- p.Arg236Trp Single submitter ⚠
- p.Arg378Gly Single submitter ⚠
- p.Arg384Lys Single submitter ⚠
- p.Arg67Trp Single submitter ⚠
- p.Arg97Cys Single submitter ⚠
- p.Asn337His Single submitter
- p.Asn74Ile Single submitter ⚠
- p.Asp84His Single submitter ⚠
- p.Cys310Arg Single submitter ⚠
- p.Glu223Gln Single submitter ⚠
- p.Glu27Gln Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly271Arg Single submitter ⚠
- p.Gly292Ser Single submitter ⚠
- p.Gly396Arg Single submitter ⚠
- p.Gly90Arg Single submitter ⚠
- p.Ile350Val Single submitter ⚠
- p.Ile358Phe Single submitter ⚠
- p.Leu202Phe Single submitter ⚠
- p.Leu369Met Single submitter ⚠
- p.Leu86Phe Single submitter ⚠
- p.Met129Arg Single submitter ⚠
- p.Pro103Ser Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Pro216Arg Single submitter ⚠
- p.Pro237Arg Single submitter ⚠
- p.Pro280Leu Single submitter ⚠
- p.Ser200Leu Single submitter ⚠
- p.Ser204Trp Single submitter ⚠
- p.Ser205Leu Single submitter ⚠
- p.Ser211Ala Single submitter ⚠
- p.Ser217Pro Single submitter ⚠
- p.Ser232Thr Single submitter ⚠
- p.Ser277Arg Single submitter ⚠
- p.Ser31Leu Single submitter ⚠
- p.Thr194Asn Single submitter ⚠
- p.Thr296Ile Single submitter ⚠
- p.Tyr123Ser Single submitter ⚠
- p.Val188Ala Single submitter ⚠
- p.Val188Ile Single submitter ⚠
- p.Val247Ile Single submitter ⚠
- p.Val251Phe Single submitter ⚠
- p.Val304Ala Single submitter ⚠
- p.Val316Ala Single submitter ⚠
- p.Val50Ile Single submitter ⚠