MLST8 — 39 ClinVar variants
All ClinVar germline MLST8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
3 Likely benign · 36 Uncertain significance
Full MLST8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MLST8 p.Ala223Thr Uncertain significance Single submitter
- MLST8 p.Arg66Leu Uncertain significance Single submitter
- MLST8 p.Asn132Lys Uncertain significance Single submitter
- MLST8 p.Asn321Ser Uncertain significance Single submitter
- MLST8 p.Gln63Leu Uncertain significance Single submitter
- MLST8 p.Glu170Ala Uncertain significance Single submitter
- MLST8 p.Glu170Asp Uncertain significance Single submitter
- MLST8 p.Gly192Glu Uncertain significance Single submitter
- MLST8 p.Gly266Arg Uncertain significance Single submitter
- MLST8 p.Gly275Ser Uncertain significance Single submitter
- MLST8 p.His64Arg Uncertain significance Single submitter
- MLST8 p.Ile152Val Uncertain significance Single submitter
- MLST8 p.Ile260Met Uncertain significance Single submitter
- MLST8 p.Leu325Met Uncertain significance Single submitter
- MLST8 p.Met185Val Uncertain significance Single submitter
- MLST8 p.Pro230Leu Uncertain significance Single submitter
- MLST8 p.Pro52Leu Uncertain significance Single submitter
- MLST8 p.Pro5Ser Uncertain significance Single submitter
- MLST8 p.Ser175Phe Uncertain significance Single submitter
- MLST8 p.Thr102Met Uncertain significance Single submitter
- MLST8 p.Thr191Asn Uncertain significance Single submitter
- MLST8 p.Thr200Met Uncertain significance Single submitter
- MLST8 p.Thr220Met Uncertain significance Single submitter
- MLST8 p.Thr237Ile Uncertain significance Single submitter
- MLST8 p.Thr243Met Uncertain significance Single submitter
- MLST8 p.Thr256Met Uncertain significance Single submitter
- MLST8 p.Val286Ile Uncertain significance Single submitter
- MLST8 p.Val84Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- MLST8 p.Arg227Cys Uncertain significance Single submitter
- MLST8 p.Arg227His Uncertain significance Single submitter
- MLST8 p.Arg25His Uncertain significance Single submitter
- MLST8 p.Asp179His Uncertain significance Single submitter
- MLST8 p.Gln126His Uncertain significance Single submitter
- MLST8 p.Glu303Lys Uncertain significance Single submitter
All MLST8 variants
Uncertain significance 36
- p.Ala223Thr Single submitter ⚠
- p.Arg221Cys Single submitter
- p.Arg227Cys Single submitter ⚠
- p.Arg227His Single submitter ⚠
- p.Arg25His Single submitter ⚠
- p.Arg66Leu Single submitter ⚠
- p.Asn132Lys Single submitter ⚠
- p.Asn321Ser Single submitter ⚠
- p.Asp179His Single submitter ⚠
- p.Gln126His Single submitter ⚠
- p.Gln63Leu Single submitter ⚠
- p.Glu170Ala Single submitter ⚠
- p.Glu170Asp Single submitter ⚠
- p.Glu303Lys Single submitter ⚠
- p.Gly192Glu Single submitter ⚠
- p.Gly266Arg Single submitter ⚠
- p.Gly275Ser Single submitter ⚠
- p.Gly326Asp Single submitter
- p.His64Arg Single submitter ⚠
- p.Ile152Val Single submitter ⚠
- p.Ile260Met Single submitter ⚠
- p.Leu325Met Single submitter ⚠
- p.Met185Val Single submitter ⚠
- p.Pro230Leu Single submitter ⚠
- p.Pro52Leu Single submitter ⚠
- p.Pro5Ser Single submitter ⚠
- p.Ser175Phe Single submitter ⚠
- p.Thr102Met Single submitter ⚠
- p.Thr191Asn Single submitter ⚠
- p.Thr200Met Single submitter ⚠
- p.Thr220Met Single submitter ⚠
- p.Thr237Ile Single submitter ⚠
- p.Thr243Met Single submitter ⚠
- p.Thr256Met Single submitter ⚠
- p.Val286Ile Single submitter ⚠
- p.Val84Leu Single submitter ⚠