MLX — 33 ClinVar variants
All ClinVar germline MLX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
2 Benign · 2 Likely benign · 29 Uncertain significance
Full MLX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MLX p.Arg229Gln Uncertain significance Single submitter
- MLX p.Arg34Cys Uncertain significance Single submitter
- MLX p.Asn200Ser Uncertain significance Single submitter
- MLX p.Gln242Arg Uncertain significance Single submitter
- MLX p.Glu174Asp Uncertain significance Single submitter
- MLX p.Glu31Gly Uncertain significance Single submitter
- MLX p.His64Tyr Uncertain significance Single submitter
- MLX p.Ile231Thr Uncertain significance Single submitter
- MLX p.Ile233Ser Uncertain significance Single submitter
- MLX p.Leu28His Uncertain significance Single submitter
- MLX p.Leu28Phe Uncertain significance Single submitter
- MLX p.Lys155Arg Uncertain significance Single submitter
- MLX p.Lys35Arg Uncertain significance Single submitter
- MLX p.Ser23Ile Uncertain significance Single submitter
- MLX p.Ser47Phe Uncertain significance Single submitter
- MLX p.Ser61Gly Uncertain significance Single submitter
- MLX p.Thr146Met Uncertain significance Single submitter
- MLX p.Thr33Ile Uncertain significance Single submitter
- MLX p.Val102Ile Uncertain significance Single submitter
- MLX p.Val232Ala Uncertain significance Single submitter
- MLX p.Arg75Trp Uncertain significance No assertion criteria
Predictors split 4
The independent predictors disagree with each other — read with care.
All MLX variants
Benign 2
- p.Gln169Arg Multiple submitters
- p.Asp25= Single submitter
Likely benign 2
- c.170-5C>T Single submitter
- p.Ile45= Single submitter
Uncertain significance 29
- p.Arg229Gln Single submitter ⚠
- p.Arg229Trp Single submitter ⚠
- p.Arg34Cys Single submitter ⚠
- p.Asn200Ser Single submitter ⚠
- p.Gln115His Single submitter ⚠
- p.Gln140Arg Single submitter ⚠
- p.Gln242Arg Single submitter ⚠
- p.Glu174Asp Single submitter ⚠
- p.Glu31Gly Single submitter ⚠
- p.Gly46Ser Single submitter
- p.His168Arg Single submitter
- p.His64Tyr Single submitter ⚠
- p.Ile231Thr Single submitter ⚠
- p.Ile233Ser Single submitter ⚠
- p.Leu28His Single submitter ⚠
- p.Leu28Phe Single submitter ⚠
- p.Lys155Arg Single submitter ⚠
- p.Lys155Asn Single submitter ⚠
- p.Lys35Arg Single submitter ⚠
- p.Ser23Ile Single submitter ⚠
- p.Ser47Phe Single submitter ⚠
- p.Ser52Ala Single submitter
- p.Ser61Gly Single submitter ⚠
- p.Thr146Met Single submitter ⚠
- p.Thr33Ile Single submitter ⚠
- p.Thr48Ala Single submitter
- p.Val102Ile Single submitter ⚠
- p.Val232Ala Single submitter ⚠
- p.Arg75Trp No assertion criteria ⚠