Sugi Variant

Sugi Variant/MMP14

MMP14 — 362 ClinVar variants

All ClinVar germline MMP14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 186 flagged for review →

2 Pathogenic · 1 Conflicting · 35 Benign · 2 Benign/Likely benign · 116 Likely benign · 206 Uncertain significance

Full MMP14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 186

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 133

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 51

The independent predictors disagree with each other — read with care.

All MMP14 variants

Pathogenic 2

Conflicting classifications of pathogenicity 1

Benign 35

Benign/Likely benign 2

Likely benign 116

Uncertain significance 206