MMP24 — 94 ClinVar variants
All ClinVar germline MMP24 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
1 Benign · 3 Likely benign · 90 Uncertain significance
Full MMP24 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MMP24 p.Ala100Gly Uncertain significance Single submitter
- MMP24 p.Ala106Val Uncertain significance Single submitter
- MMP24 p.Ala50Pro Uncertain significance Single submitter
- MMP24 p.Ala50Thr Uncertain significance Single submitter
- MMP24 p.Ala604Ser Uncertain significance Single submitter
- MMP24 p.Ala75Thr Uncertain significance Single submitter
- MMP24 p.Ala75Val Uncertain significance Single submitter
- MMP24 p.Ala80Val Uncertain significance Single submitter
- MMP24 p.Arg138Gln Uncertain significance Single submitter
- MMP24 p.Arg149His Uncertain significance Single submitter
- MMP24 p.Arg151Gln Uncertain significance Single submitter
- MMP24 p.Arg164Lys Uncertain significance Single submitter
- MMP24 p.Arg345His Uncertain significance Single submitter
- MMP24 p.Arg363Gln Uncertain significance Single submitter
- MMP24 p.Arg391Gln Uncertain significance Single submitter
- MMP24 p.Arg3Lys Uncertain significance Single submitter
- MMP24 p.Arg406Cys Uncertain significance Single submitter
- MMP24 p.Arg428Cys Uncertain significance Single submitter
- MMP24 p.Arg473His Uncertain significance Single submitter
- MMP24 p.Arg576Gln Uncertain significance Single submitter
- MMP24 p.Arg581Gln Uncertain significance Single submitter
- MMP24 p.Arg581Trp Uncertain significance Single submitter
- MMP24 p.Arg62Gly Uncertain significance Single submitter
- MMP24 p.Arg71Pro Uncertain significance Single submitter
- MMP24 p.Arg97Trp Uncertain significance Single submitter
- MMP24 p.Asn268Asp Uncertain significance Single submitter
- MMP24 p.Asn594Ile Uncertain significance Single submitter
- MMP24 p.Asp193Asn Uncertain significance Single submitter
- MMP24 p.Asp318Asn Uncertain significance Single submitter
- MMP24 p.Asp586Glu Uncertain significance Single submitter
- MMP24 p.Asp595Asn Uncertain significance Single submitter
- MMP24 p.Asp73Ala Uncertain significance Single submitter
- MMP24 p.Cys45Phe Uncertain significance Single submitter
- MMP24 p.Gln108Glu Uncertain significance Single submitter
- MMP24 p.Gln22Leu Uncertain significance Single submitter
- MMP24 p.Gln420His Uncertain significance Single submitter
- MMP24 p.Glu331Lys Uncertain significance Single submitter
- MMP24 p.Glu393Gln Uncertain significance Single submitter
- MMP24 p.Glu412Lys Uncertain significance Single submitter
- MMP24 p.Glu501Lys Uncertain significance Single submitter
- MMP24 p.Glu573Val Uncertain significance Single submitter
- MMP24 p.Gly140Cys Uncertain significance Single submitter
- MMP24 p.Gly48Ser Uncertain significance Single submitter
- MMP24 p.Gly7Ser Uncertain significance Single submitter
- MMP24 p.Gly81Arg Uncertain significance Single submitter
- MMP24 p.His167Arg Uncertain significance Single submitter
- MMP24 p.His209Asn Uncertain significance Single submitter
- MMP24 p.Ile325Thr Uncertain significance Single submitter
- MMP24 p.Ile562Met Uncertain significance Single submitter
- MMP24 p.Ile593Met Uncertain significance Single submitter
- MMP24 p.Leu290Met Uncertain significance Single submitter
- MMP24 p.Leu35Arg Uncertain significance Single submitter
- MMP24 p.Leu366Pro Uncertain significance Single submitter
- MMP24 p.Lys216Asn Uncertain significance Single submitter
- MMP24 p.Met590Val Uncertain significance Single submitter
- MMP24 p.Pro11Leu Uncertain significance Single submitter
- MMP24 p.Pro13Gln Uncertain significance Single submitter
- MMP24 p.Pro145Ser Uncertain significance Single submitter
- MMP24 p.Pro16Ser Uncertain significance Single submitter
- MMP24 p.Pro332Ala Uncertain significance Single submitter
- MMP24 p.Pro359Leu Uncertain significance Single submitter
- MMP24 p.Pro47Leu Uncertain significance Single submitter
- MMP24 p.Pro633Ala Uncertain significance Single submitter
- MMP24 p.Ser371Pro Uncertain significance Single submitter
- MMP24 p.Thr256Ile Uncertain significance Single submitter
- MMP24 p.Thr455Ala Uncertain significance Single submitter
- MMP24 p.Tyr90Cys Uncertain significance Single submitter
- MMP24 p.Val111Ile Uncertain significance Single submitter
- MMP24 p.Val31Ala Uncertain significance Single submitter
- MMP24 p.Val574Glu Uncertain significance Single submitter
- MMP24 p.Val600Met Uncertain significance Single submitter
- MMP24 p.Val603Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- MMP24 p.Ala52Thr Uncertain significance Single submitter
- MMP24 p.Arg149Cys Uncertain significance Single submitter
- MMP24 p.Arg215Trp Uncertain significance Single submitter
- MMP24 p.Arg428Pro Uncertain significance Single submitter
- MMP24 p.Arg504Trp Uncertain significance Single submitter
- MMP24 p.Asp261Asn Uncertain significance Single submitter
- MMP24 p.Lys447Glu Uncertain significance Single submitter
- MMP24 p.Lys452Asn Uncertain significance Single submitter
- MMP24 p.Lys638Asn Uncertain significance Single submitter
- MMP24 p.Met416Thr Uncertain significance Single submitter
- MMP24 p.Pro121Leu Uncertain significance Single submitter
- MMP24 p.Pro14Gln Uncertain significance Single submitter
- MMP24 p.Pro18Leu Uncertain significance Single submitter
- MMP24 p.Pro207Ser Uncertain significance Single submitter
- MMP24 p.Pro296Ser Uncertain significance Single submitter
- MMP24 p.Val645Met Uncertain significance Single submitter
- MMP24 p.Val67Met Uncertain significance Single submitter
All MMP24 variants
Benign 1
- p.Thr256= Multiple submitters
Likely benign 3
- p.Asp381= Single submitter
- p.Ile429= Single submitter
- p.Pro15Ser Single submitter
Uncertain significance 90
- p.Ala100Gly Single submitter ⚠
- p.Ala106Val Single submitter ⚠
- p.Ala50Pro Single submitter ⚠
- p.Ala50Thr Single submitter ⚠
- p.Ala52Thr Single submitter ⚠
- p.Ala604Ser Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Ala75Val Single submitter ⚠
- p.Ala80Val Single submitter ⚠
- p.Arg138Gln Single submitter ⚠
- p.Arg149Cys Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Arg151Gln Single submitter ⚠
- p.Arg164Lys Single submitter ⚠
- p.Arg215Trp Single submitter ⚠
- p.Arg345His Single submitter ⚠
- p.Arg363Gln Single submitter ⚠
- p.Arg391Gln Single submitter ⚠
- p.Arg3Lys Single submitter ⚠
- p.Arg406Cys Single submitter ⚠
- p.Arg428Cys Single submitter ⚠
- p.Arg428Pro Single submitter ⚠
- p.Arg473His Single submitter ⚠
- p.Arg504Trp Single submitter ⚠
- p.Arg576Gln Single submitter ⚠
- p.Arg581Gln Single submitter ⚠
- p.Arg581Trp Single submitter ⚠
- p.Arg62Gly Single submitter ⚠
- p.Arg71Pro Single submitter ⚠
- p.Arg97Trp Single submitter ⚠
- p.Asn268Asp Single submitter ⚠
- p.Asn594Ile Single submitter ⚠
- p.Asp193Asn Single submitter ⚠
- p.Asp261Asn Single submitter ⚠
- p.Asp318Asn Single submitter ⚠
- p.Asp586Glu Single submitter ⚠
- p.Asp595Asn Single submitter ⚠
- p.Asp73Ala Single submitter ⚠
- p.Cys45Phe Single submitter ⚠
- p.Gln108Glu Single submitter ⚠
- p.Gln22Leu Single submitter ⚠
- p.Gln420His Single submitter ⚠
- p.Glu331Lys Single submitter ⚠
- p.Glu393Gln Single submitter ⚠
- p.Glu412Lys Single submitter ⚠
- p.Glu501Lys Single submitter ⚠
- p.Glu573Val Single submitter ⚠
- p.Gly140Cys Single submitter ⚠
- p.Gly48Ser Single submitter ⚠
- p.Gly7Ser Single submitter ⚠
- p.Gly81Arg Single submitter ⚠
- p.His167Arg Single submitter ⚠
- p.His209Asn Single submitter ⚠
- p.Ile325Thr Single submitter ⚠
- p.Ile562Met Single submitter ⚠
- p.Ile593Met Single submitter ⚠
- p.Leu290Met Single submitter ⚠
- p.Leu35Arg Single submitter ⚠
- p.Leu366Pro Single submitter ⚠
- p.Lys216Asn Single submitter ⚠
- p.Lys447Glu Single submitter ⚠
- p.Lys452Asn Single submitter ⚠
- p.Lys638Asn Single submitter ⚠
- p.Met416Thr Single submitter ⚠
- p.Met590Val Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro121Leu Single submitter ⚠
- p.Pro13Gln Single submitter ⚠
- p.Pro145Ser Single submitter ⚠
- p.Pro14Gln Single submitter ⚠
- p.Pro16Ser Single submitter ⚠
- p.Pro18Leu Single submitter ⚠
- p.Pro207Ser Single submitter ⚠
- p.Pro296Ser Single submitter ⚠
- p.Pro332Ala Single submitter ⚠
- p.Pro359Leu Single submitter ⚠
- p.Pro47Leu Single submitter ⚠
- p.Pro633Ala Single submitter ⚠
- p.Ser371Pro Single submitter ⚠
- p.Thr256Ile Single submitter ⚠
- p.Thr265Met Single submitter
- p.Thr455Ala Single submitter ⚠
- p.Tyr90Cys Single submitter ⚠
- p.Val111Ile Single submitter ⚠
- p.Val31Ala Single submitter ⚠
- p.Val574Glu Single submitter ⚠
- p.Val600Met Single submitter ⚠
- p.Val603Met Single submitter ⚠
- p.Val645Met Single submitter ⚠
- p.Val67Met Single submitter ⚠