MMP25 — 122 ClinVar variants
All ClinVar germline MMP25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 117 flagged for review →
2 Likely benign · 120 Uncertain significance
Full MMP25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 117
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 86
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MMP25 p.Ala109Thr Uncertain significance Single submitter
- MMP25 p.Ala177Thr Uncertain significance Single submitter
- MMP25 p.Ala193Asp Uncertain significance Single submitter
- MMP25 p.Ala282Val Uncertain significance Single submitter
- MMP25 p.Ala325Thr Uncertain significance Single submitter
- MMP25 p.Ala402Pro Uncertain significance Single submitter
- MMP25 p.Ala472Gly Uncertain significance Single submitter
- MMP25 p.Ala497Asp Uncertain significance Single submitter
- MMP25 p.Ala517Val Uncertain significance Single submitter
- MMP25 p.Ala560Val Uncertain significance Single submitter
- MMP25 p.Arg105His Uncertain significance Single submitter
- MMP25 p.Arg125His Uncertain significance Single submitter
- MMP25 p.Arg2Trp Uncertain significance Single submitter
- MMP25 p.Arg355Gln Uncertain significance Single submitter
- MMP25 p.Arg378Leu Uncertain significance Single submitter
- MMP25 p.Arg445Ser Uncertain significance Single submitter
- MMP25 p.Arg519Lys Uncertain significance Single submitter
- MMP25 p.Arg542Gly Uncertain significance Single submitter
- MMP25 p.Asp181His Uncertain significance Single submitter
- MMP25 p.Asp206Tyr Uncertain significance Single submitter
- MMP25 p.Asp466Ala Uncertain significance Single submitter
- MMP25 p.Cys530Gly Uncertain significance Single submitter
- MMP25 p.Gln129Arg Uncertain significance Single submitter
- MMP25 p.Gln499His Uncertain significance Single submitter
- MMP25 p.Gln538His Uncertain significance Single submitter
- MMP25 p.Gln66Arg Uncertain significance Single submitter
- MMP25 p.Glu200Lys Uncertain significance Single submitter
- MMP25 p.Glu414Gln Uncertain significance Single submitter
- MMP25 p.Glu415Lys Uncertain significance Single submitter
- MMP25 p.Glu441Asp Uncertain significance Single submitter
- MMP25 p.Gly112Ser Uncertain significance Single submitter
- MMP25 p.Gly187Trp Uncertain significance Single submitter
- MMP25 p.Gly380Arg Uncertain significance Single submitter
- MMP25 p.Gly380Asp Uncertain significance Single submitter
- MMP25 p.Gly380Ser Uncertain significance Single submitter
- MMP25 p.Gly426Arg Uncertain significance Single submitter
- MMP25 p.Gly557Val Uncertain significance Single submitter
- MMP25 p.Gly75Cys Uncertain significance Single submitter
- MMP25 p.Gly75Ser Uncertain significance Single submitter
- MMP25 p.Gly80Arg Uncertain significance Single submitter
- MMP25 p.His233Leu Uncertain significance Single submitter
- MMP25 p.His377Tyr Uncertain significance Single submitter
- MMP25 p.His46Pro Uncertain significance Single submitter
- MMP25 p.Ile170Asn Uncertain significance Single submitter
- MMP25 p.Ile203Val Uncertain significance Single submitter
- MMP25 p.Leu348Val Uncertain significance Single submitter
- MMP25 p.Leu550Phe Uncertain significance Single submitter
- MMP25 p.Leu8Gln Uncertain significance Single submitter
- MMP25 p.Lys116Asn Uncertain significance Single submitter
- MMP25 p.Lys264Glu Uncertain significance Single submitter
- MMP25 p.Lys522Arg Uncertain significance Single submitter
- MMP25 p.Lys63Glu Uncertain significance Single submitter
- MMP25 p.Met142Arg Uncertain significance Single submitter
- MMP25 p.Met142Thr Uncertain significance Single submitter
- MMP25 p.Met501Leu Uncertain significance Single submitter
- MMP25 p.Met85Lys Uncertain significance Single submitter
- MMP25 p.Phe174Leu Uncertain significance Single submitter
- MMP25 p.Phe228Ser Uncertain significance Single submitter
- MMP25 p.Phe311Leu Uncertain significance Single submitter
- MMP25 p.Pro17Leu Uncertain significance Single submitter
- MMP25 p.Pro198Leu Uncertain significance Single submitter
- MMP25 p.Pro22Arg Uncertain significance Single submitter
- MMP25 p.Pro247Ser Uncertain significance Single submitter
- MMP25 p.Pro24Leu Uncertain significance Single submitter
- MMP25 p.Pro24Thr Uncertain significance Single submitter
- MMP25 p.Pro298Leu Uncertain significance Single submitter
- MMP25 p.Pro500Arg Uncertain significance Single submitter
- MMP25 p.Pro515Ser Uncertain significance Single submitter
- MMP25 p.Pro520Leu Uncertain significance Single submitter
- MMP25 p.Pro525Ser Uncertain significance Single submitter
- MMP25 p.Pro548Ser Uncertain significance Single submitter
- MMP25 p.Pro72Arg Uncertain significance Single submitter
- MMP25 p.Ser111Asn Uncertain significance Single submitter
- MMP25 p.Ser111Gly Uncertain significance Single submitter
- MMP25 p.Ser345Phe Uncertain significance Single submitter
- MMP25 p.Ser512Asn Uncertain significance Single submitter
- MMP25 p.Ser54Gly Uncertain significance Single submitter
- MMP25 p.Thr207Ala Uncertain significance Single submitter
- MMP25 p.Thr37Ile Uncertain significance Single submitter
- MMP25 p.Thr81Ile Uncertain significance Single submitter
- MMP25 p.Tyr287His Uncertain significance Single submitter
- MMP25 p.Tyr374His Uncertain significance Single submitter
- MMP25 p.Tyr39Ser Uncertain significance Single submitter
- MMP25 p.Val29Met Uncertain significance Single submitter
- MMP25 p.Val431Phe Uncertain significance Single submitter
- MMP25 p.Val64Ile Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- MMP25 p.Ala539Val Uncertain significance Single submitter
- MMP25 p.Arg104Trp Uncertain significance Single submitter
- MMP25 p.Arg106Cys Uncertain significance Single submitter
- MMP25 p.Arg107Gln Uncertain significance Single submitter
- MMP25 p.Arg107Trp Uncertain significance Single submitter
- MMP25 p.Arg125Cys Uncertain significance Single submitter
- MMP25 p.Arg139Gly Uncertain significance Single submitter
- MMP25 p.Arg139Trp Uncertain significance Single submitter
- MMP25 p.Arg176Cys Uncertain significance Single submitter
- MMP25 p.Arg176His Uncertain significance Single submitter
- MMP25 p.Arg376Gln Uncertain significance Single submitter
- MMP25 p.Arg376Gly Uncertain significance Single submitter
- MMP25 p.Arg38Cys Uncertain significance Single submitter
- MMP25 p.Asp186Glu Uncertain significance Single submitter
- MMP25 p.Asp261Tyr Uncertain significance Single submitter
- MMP25 p.Asp34Tyr Uncertain significance Single submitter
- MMP25 p.Asp466Asn Uncertain significance Single submitter
- MMP25 p.Gln499Pro Uncertain significance Single submitter
- MMP25 p.Glu159Lys Uncertain significance Single submitter
- MMP25 p.Glu407Val Uncertain significance Single submitter
- MMP25 p.Gly514Cys Uncertain significance Single submitter
- MMP25 p.Ile203Thr Uncertain significance Single submitter
- MMP25 p.Leu555Met Uncertain significance Single submitter
- MMP25 p.Leu7Phe Uncertain significance Single submitter
- MMP25 p.Leu92Arg Uncertain significance Single submitter
- MMP25 p.Phe477Leu Uncertain significance Single submitter
- MMP25 p.Phe477Val Uncertain significance Single submitter
- MMP25 p.Pro262Thr Uncertain significance Single submitter
- MMP25 p.Pro353Ser Uncertain significance Single submitter
- MMP25 p.Pro411Leu Uncertain significance Single submitter
- MMP25 p.Trp338Cys Uncertain significance Single submitter
All MMP25 variants
Likely benign 2
- p.Ala472Thr Single submitter
- p.Ala497Ser Single submitter
Uncertain significance 120
- p.Ala109Thr Single submitter ⚠
- p.Ala177Thr Single submitter ⚠
- p.Ala193Asp Single submitter ⚠
- p.Ala282Val Single submitter ⚠
- p.Ala325Thr Single submitter ⚠
- p.Ala402Pro Single submitter ⚠
- p.Ala472Gly Single submitter ⚠
- p.Ala497Asp Single submitter ⚠
- p.Ala517Val Single submitter ⚠
- p.Ala539Val Single submitter ⚠
- p.Ala560Val Single submitter ⚠
- p.Arg104Trp Single submitter ⚠
- p.Arg105His Single submitter ⚠
- p.Arg106Cys Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg107Trp Single submitter ⚠
- p.Arg125Cys Single submitter ⚠
- p.Arg125His Single submitter ⚠
- p.Arg139Gly Single submitter ⚠
- p.Arg139Trp Single submitter ⚠
- p.Arg176Cys Single submitter ⚠
- p.Arg176His Single submitter ⚠
- p.Arg176Pro Single submitter
- p.Arg2Trp Single submitter ⚠
- p.Arg355Gln Single submitter ⚠
- p.Arg376Gln Single submitter ⚠
- p.Arg376Gly Single submitter ⚠
- p.Arg378Leu Single submitter ⚠
- p.Arg38Cys Single submitter ⚠
- p.Arg445Ser Single submitter ⚠
- p.Arg519Lys Single submitter ⚠
- p.Arg542Gly Single submitter ⚠
- p.Asp181His Single submitter ⚠
- p.Asp186Glu Single submitter ⚠
- p.Asp206Tyr Single submitter ⚠
- p.Asp261Tyr Single submitter ⚠
- p.Asp34Tyr Single submitter ⚠
- p.Asp466Ala Single submitter ⚠
- p.Asp466Asn Single submitter ⚠
- p.Cys530Gly Single submitter ⚠
- p.Gln129Arg Single submitter ⚠
- p.Gln499His Single submitter ⚠
- p.Gln499Pro Single submitter ⚠
- p.Gln538His Single submitter ⚠
- p.Gln66Arg Single submitter ⚠
- p.Glu159Lys Single submitter ⚠
- p.Glu200Lys Single submitter ⚠
- p.Glu407Val Single submitter ⚠
- p.Glu414Gln Single submitter ⚠
- p.Glu415Lys Single submitter ⚠
- p.Glu441Asp Single submitter ⚠
- p.Gly112Ser Single submitter ⚠
- p.Gly187Trp Single submitter ⚠
- p.Gly380Arg Single submitter ⚠
- p.Gly380Asp Single submitter ⚠
- p.Gly380Ser Single submitter ⚠
- p.Gly426Arg Single submitter ⚠
- p.Gly514Cys Single submitter ⚠
- p.Gly557Val Single submitter ⚠
- p.Gly75Cys Single submitter ⚠
- p.Gly75Ser Single submitter ⚠
- p.Gly80Arg Single submitter ⚠
- p.His233Leu Single submitter ⚠
- p.His377Tyr Single submitter ⚠
- p.His46Pro Single submitter ⚠
- p.Ile170Asn Single submitter ⚠
- p.Ile203Thr Single submitter ⚠
- p.Ile203Val Single submitter ⚠
- p.Leu348Val Single submitter ⚠
- p.Leu550Phe Single submitter ⚠
- p.Leu555Met Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Leu8Gln Single submitter ⚠
- p.Leu92Arg Single submitter ⚠
- p.Lys116Asn Single submitter ⚠
- p.Lys264Glu Single submitter ⚠
- p.Lys522Arg Single submitter ⚠
- p.Lys63Glu Single submitter ⚠
- p.Met142Arg Single submitter ⚠
- p.Met142Thr Single submitter ⚠
- p.Met501Leu Single submitter ⚠
- p.Met85Lys Single submitter ⚠
- p.Phe174Leu Single submitter ⚠
- p.Phe228Ser Single submitter ⚠
- p.Phe311Leu Single submitter ⚠
- p.Phe477Leu Single submitter ⚠
- p.Phe477Val Single submitter ⚠
- p.Pro17Leu Single submitter ⚠
- p.Pro198Leu Single submitter ⚠
- p.Pro22Arg Single submitter ⚠
- p.Pro247Ser Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro24Thr Single submitter ⚠
- p.Pro262Thr Single submitter ⚠
- p.Pro298Leu Single submitter ⚠
- p.Pro353Ser Single submitter ⚠
- p.Pro411Leu Single submitter ⚠
- p.Pro500Arg Single submitter ⚠
- p.Pro515Ser Single submitter ⚠
- p.Pro520Leu Single submitter ⚠
- p.Pro525Ser Single submitter ⚠
- p.Pro548Ser Single submitter ⚠
- p.Pro72Arg Single submitter ⚠
- p.Ser111Asn Single submitter ⚠
- p.Ser111Gly Single submitter ⚠
- p.Ser345Phe Single submitter ⚠
- p.Ser512Asn Single submitter ⚠
- p.Ser54Gly Single submitter ⚠
- p.Thr207Ala Single submitter ⚠
- p.Thr37Ile Single submitter ⚠
- p.Thr81Ile Single submitter ⚠
- p.Trp338Cys Single submitter ⚠
- p.Tyr287His Single submitter ⚠
- p.Tyr374Cys Single submitter
- p.Tyr374His Single submitter ⚠
- p.Tyr39Ser Single submitter ⚠
- p.Val29Met Single submitter ⚠
- p.Val431Phe Single submitter ⚠
- p.Val64Ile Single submitter ⚠
- p.Arg118Ter No assertion criteria Mendelian syndromes with cleft lip/palate