MMP26 — 45 ClinVar variants
All ClinVar germline MMP26 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
5 Likely benign · 40 Uncertain significance
Full MMP26 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MMP26 p.Arg107Ser Uncertain significance Single submitter
- MMP26 p.Arg63Trp Uncertain significance Single submitter
- MMP26 p.Asn110Ser Uncertain significance Single submitter
- MMP26 p.Asn201Ser Uncertain significance Single submitter
- MMP26 p.Asn221Ser Uncertain significance Single submitter
- MMP26 p.Asp86Tyr Uncertain significance Single submitter
- MMP26 p.Gln141Lys Uncertain significance Single submitter
- MMP26 p.Gln51Arg Uncertain significance Single submitter
- MMP26 p.Gln60Lys Uncertain significance Single submitter
- MMP26 p.Gln72Arg Uncertain significance Single submitter
- MMP26 p.Glu209Asp Uncertain significance Single submitter
- MMP26 p.Glu52Val Uncertain significance Single submitter
- MMP26 p.Gly211Glu Uncertain significance Single submitter
- MMP26 p.Gly34Val Uncertain significance Single submitter
- MMP26 p.His250Asn Uncertain significance Single submitter
- MMP26 p.His250Leu Uncertain significance Single submitter
- MMP26 p.Ile130Phe Uncertain significance Single submitter
- MMP26 p.Leu69Arg Uncertain significance Single submitter
- MMP26 p.Met226Thr Uncertain significance Single submitter
- MMP26 p.Pro13Leu Uncertain significance Single submitter
- MMP26 p.Pro182Ala Uncertain significance Single submitter
- MMP26 p.Pro22Ala Uncertain significance Single submitter
- MMP26 p.Ser129Phe Uncertain significance Single submitter
- MMP26 p.Thr42Ser Uncertain significance Single submitter
- MMP26 p.Thr9Ser Uncertain significance Single submitter
- MMP26 p.Trp193Arg Uncertain significance Single submitter
- MMP26 p.Tyr200His Uncertain significance Single submitter
- MMP26 p.Tyr252Cys Uncertain significance Single submitter
- MMP26 p.Val4Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- MMP26 p.Asn201Ile Uncertain significance Single submitter
- MMP26 p.Gln249His Uncertain significance Single submitter
- MMP26 p.Phe175Leu Uncertain significance Single submitter
- MMP26 p.Ser118Cys Uncertain significance Single submitter
-
MMP26 p.Ser132Asn
Uncertain significance
Single submitter
myoepithelial tumor
- MMP26 p.Ser213Pro Uncertain significance Single submitter
- MMP26 p.Trp99Cys Uncertain significance Single submitter
- MMP26 p.Tyr232Asn Uncertain significance Single submitter
- MMP26 p.Val120Leu Uncertain significance Single submitter
- MMP26 p.Val134Ala Uncertain significance Single submitter
All MMP26 variants
Likely benign 5
- p.Ser46Leu Multiple submitters
- p.Ala17Thr Single submitter
- p.Asp89Asn Single submitter
- p.Lys150= Single submitter
- p.Val18Ile Single submitter
Uncertain significance 40
- p.Arg107Ser Single submitter ⚠
- p.Arg63Trp Single submitter ⚠
- p.Asn110Ser Single submitter ⚠
- p.Asn201Ile Single submitter ⚠
- p.Asn201Ser Single submitter ⚠
- p.Asn221Ser Single submitter ⚠
- p.Asp86Tyr Single submitter ⚠
- p.Gln141Lys Single submitter ⚠
- p.Gln249His Single submitter ⚠
- p.Gln51Arg Single submitter ⚠
- p.Gln60Lys Single submitter ⚠
- p.Gln72Arg Single submitter ⚠
- p.Glu209Asp Single submitter ⚠
- p.Glu52Val Single submitter ⚠
- p.Gly211Glu Single submitter ⚠
- p.Gly34Val Single submitter ⚠
- p.Gly83Glu Single submitter
- p.His250Asn Single submitter ⚠
- p.His250Leu Single submitter ⚠
- p.Ile130Phe Single submitter ⚠
- p.Leu69Arg Single submitter ⚠
- p.Met226Thr Single submitter ⚠
- p.Phe175Leu Single submitter ⚠
- p.Pro13Leu Single submitter ⚠
- p.Pro182Ala Single submitter ⚠
- p.Pro22Ala Single submitter ⚠
- p.Ser118Cys Single submitter ⚠
- p.Ser129Phe Single submitter ⚠
- p.Ser132Asn Single submitter myoepithelial tumor ⚠
- p.Ser213Pro Single submitter ⚠
- p.Thr42Ser Single submitter ⚠
- p.Thr9Ser Single submitter ⚠
- p.Trp193Arg Single submitter ⚠
- p.Trp99Cys Single submitter ⚠
- p.Tyr200His Single submitter ⚠
- p.Tyr232Asn Single submitter ⚠
- p.Tyr252Cys Single submitter ⚠
- p.Val120Leu Single submitter ⚠
- p.Val134Ala Single submitter ⚠
- p.Val4Leu Single submitter ⚠