MMP8 — 81 ClinVar variants
All ClinVar germline MMP8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
8 Benign · 10 Likely benign · 63 Uncertain significance
Full MMP8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MMP8 p.Ala127Ser Uncertain significance Single submitter
- MMP8 p.Ala136Asp Uncertain significance Single submitter
- MMP8 p.Ala143Ser Uncertain significance Single submitter
- MMP8 p.Ala259Ser Uncertain significance Single submitter
- MMP8 p.Ala332Val Uncertain significance Single submitter
- MMP8 p.Ala426Val Uncertain significance Single submitter
- MMP8 p.Arg292Cys Uncertain significance Single submitter
- MMP8 p.Arg68Gln Uncertain significance Single submitter
- MMP8 p.Asn177His Uncertain significance Single submitter
- MMP8 p.Asn177Ser Uncertain significance Single submitter
- MMP8 p.Asp286Gly Uncertain significance Single submitter
- MMP8 p.Gln164Arg Uncertain significance Single submitter
- MMP8 p.Gln188Arg Uncertain significance Single submitter
- MMP8 p.Gln330His Uncertain significance Single submitter
- MMP8 p.Gln67Leu Uncertain significance Single submitter
- MMP8 p.Gly55Val Uncertain significance Single submitter
- MMP8 p.His217Gln Uncertain significance Single submitter
- MMP8 p.His217Tyr Uncertain significance Single submitter
- MMP8 p.His227Tyr Uncertain significance Single submitter
- MMP8 p.His432Gln Uncertain significance Single submitter
- MMP8 p.Leu249Phe Uncertain significance Single submitter
- MMP8 p.Lys77Arg Uncertain significance Single submitter
- MMP8 p.Phe390Val Uncertain significance Single submitter
- MMP8 p.Pro186Ser Uncertain significance Single submitter
- MMP8 p.Pro231Ser Uncertain significance Single submitter
- MMP8 p.Ser373Asn Uncertain significance Single submitter
- MMP8 p.Thr102Ile Uncertain significance Single submitter
- MMP8 p.Thr111Asn Uncertain significance Single submitter
- MMP8 p.Thr290Ala Uncertain significance Single submitter
- MMP8 p.Tyr261Ser Uncertain significance Single submitter
- MMP8 p.Tyr361Asp Uncertain significance Single submitter
- MMP8 p.Tyr398Cys Uncertain significance Single submitter
- MMP8 p.Val142Ile Uncertain significance Single submitter
- MMP8 p.Val374Ile Uncertain significance Single submitter
- MMP8 p.Val58Gly Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- MMP8 p.Glu81Lys Likely benign Multiple submitters
- MMP8 p.Lys87Glu Benign Multiple submitters
- MMP8 p.Ala216Gly Uncertain significance Single submitter
- MMP8 p.Arg150Ser Uncertain significance Single submitter
- MMP8 p.Arg242Gly Uncertain significance Single submitter
- MMP8 p.Arg292His Uncertain significance Single submitter
- MMP8 p.Asn177Ile Uncertain significance Single submitter
- MMP8 p.Asn79Tyr Uncertain significance Single submitter
- MMP8 p.Asp300Asn Likely benign Single submitter
- MMP8 p.Asp337His Uncertain significance Single submitter
- MMP8 p.Asp337Tyr Uncertain significance Single submitter
- MMP8 p.Asp393Glu Uncertain significance Single submitter
- MMP8 p.Gln311Leu Uncertain significance Single submitter
- MMP8 p.Glu199Gln Uncertain significance Single submitter
- MMP8 p.Gly328Cys Uncertain significance Single submitter
- MMP8 p.Gly97Asp Uncertain significance Single submitter
- MMP8 p.Ile420Met Uncertain significance Single submitter
- MMP8 p.Leu113Val Uncertain significance Single submitter
- MMP8 p.Leu213Pro Uncertain significance Single submitter
- MMP8 p.Leu310Pro Likely benign Single submitter
- MMP8 p.Leu352Pro Uncertain significance Single submitter
- MMP8 p.Leu37Val Uncertain significance Single submitter
- MMP8 p.Lys107Thr Uncertain significance Single submitter
- MMP8 p.Phe303Ser Uncertain significance Single submitter
- MMP8 p.Phe445Leu Uncertain significance Single submitter
- MMP8 p.Pro44Leu Uncertain significance Single submitter
- MMP8 p.Ser366Thr Uncertain significance Single submitter
- MMP8 p.Ser414Leu Uncertain significance Single submitter
- MMP8 p.Thr327Ile Uncertain significance Single submitter
- MMP8 p.Tyr333Cys Uncertain significance Single submitter
- MMP8 p.Tyr355Cys Uncertain significance Single submitter
- MMP8 p.Tyr388His Uncertain significance Single submitter
All MMP8 variants
Benign 8
- p.Arg118Gln Multiple submitters
- p.Asn463Asp Multiple submitters
- p.Lys87Glu Multiple submitters ⚠
- p.Val60Ile Multiple submitters
- c.903-3T>C Single submitter
- c.903-6C>T Single submitter
- p.Arg150= Single submitter
- p.Tyr443= Single submitter
Likely benign 10
- c.785-4C>T Multiple submitters
- p.Gln450Ter Multiple submitters
- p.Glu81Lys Multiple submitters ⚠
- p.Ala207Thr Single submitter
- p.Asn347= Single submitter
- p.Asp255Asn Single submitter
- p.Asp300Asn Single submitter ⚠
- p.Asp35Asn Single submitter
- p.His217= Single submitter
- p.Leu310Pro Single submitter ⚠
Uncertain significance 63
- p.Ala127Ser Single submitter ⚠
- p.Ala136Asp Single submitter ⚠
- p.Ala143Ser Single submitter ⚠
- p.Ala216Gly Single submitter ⚠
- p.Ala259Ser Single submitter ⚠
- p.Ala332Val Single submitter ⚠
- p.Ala426Val Single submitter ⚠
- p.Arg150Ser Single submitter ⚠
- p.Arg242Gly Single submitter ⚠
- p.Arg292Cys Single submitter ⚠
- p.Arg292His Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Asn177His Single submitter ⚠
- p.Asn177Ile Single submitter ⚠
- p.Asn177Ser Single submitter ⚠
- p.Asn79Tyr Single submitter ⚠
- p.Asp286Gly Single submitter ⚠
- p.Asp337His Single submitter ⚠
- p.Asp337Tyr Single submitter ⚠
- p.Asp393Glu Single submitter ⚠
- p.Gln164Arg Single submitter ⚠
- p.Gln188Arg Single submitter ⚠
- p.Gln311Leu Single submitter ⚠
- p.Gln330His Single submitter ⚠
- p.Gln67Leu Single submitter ⚠
- p.Glu199Gln Single submitter ⚠
- p.Gly328Cys Single submitter ⚠
- p.Gly55Val Single submitter ⚠
- p.Gly97Asp Single submitter ⚠
- p.His217Gln Single submitter ⚠
- p.His217Tyr Single submitter ⚠
- p.His227Tyr Single submitter ⚠
- p.His432Gln Single submitter ⚠
- p.Ile420Met Single submitter ⚠
- p.Leu113Val Single submitter ⚠
- p.Leu213Pro Single submitter ⚠
- p.Leu249Phe Single submitter ⚠
- p.Leu352Pro Single submitter ⚠
- p.Leu37Val Single submitter ⚠
- p.Lys107Thr Single submitter ⚠
- p.Lys77Arg Single submitter ⚠
- p.Phe303Ser Single submitter ⚠
- p.Phe390Val Single submitter ⚠
- p.Phe445Leu Single submitter ⚠
- p.Pro186Ser Single submitter ⚠
- p.Pro231Ser Single submitter ⚠
- p.Pro44Leu Single submitter ⚠
- p.Ser366Thr Single submitter ⚠
- p.Ser373Asn Single submitter ⚠
- p.Ser414Leu Single submitter ⚠
- p.Thr102Ile Single submitter ⚠
- p.Thr111Asn Single submitter ⚠
- p.Thr290Ala Single submitter ⚠
- p.Thr327Ile Single submitter ⚠
- p.Tyr261Ser Single submitter ⚠
- p.Tyr333Cys Single submitter ⚠
- p.Tyr355Cys Single submitter ⚠
- p.Tyr361Asp Single submitter ⚠
- p.Tyr388His Single submitter ⚠
- p.Tyr398Cys Single submitter ⚠
- p.Val142Ile Single submitter ⚠
- p.Val374Ile Single submitter ⚠
- p.Val58Gly Single submitter ⚠