MNAT1 — 33 ClinVar variants
All ClinVar germline MNAT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 1 Likely benign · 31 Uncertain significance
Full MNAT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MNAT1 p.Ala244Thr Uncertain significance Single submitter
- MNAT1 p.Ala278Ser Uncertain significance Single submitter
- MNAT1 p.Arg155Gln Uncertain significance Single submitter
- MNAT1 p.Asn129Ser Uncertain significance Single submitter
- MNAT1 p.Asp114Tyr Uncertain significance Single submitter
- MNAT1 p.Cys34Phe Uncertain significance Single submitter
- MNAT1 p.Cys34Tyr Uncertain significance Single submitter
- MNAT1 p.Gln144Arg Uncertain significance Single submitter
- MNAT1 p.Gln166Glu Uncertain significance Single submitter
- MNAT1 p.Gln307Lys Uncertain significance Single submitter
- MNAT1 p.Glu145Gly Uncertain significance Single submitter
- MNAT1 p.Glu146Gln Uncertain significance Single submitter
- MNAT1 p.Glu213Gln Uncertain significance Single submitter
- MNAT1 p.Ile174Thr Uncertain significance Single submitter
- MNAT1 p.Ile253Met Uncertain significance Single submitter
- MNAT1 p.Leu175Arg Uncertain significance Single submitter
- MNAT1 p.Leu212Phe Uncertain significance Single submitter
- MNAT1 p.Leu241Pro Uncertain significance Single submitter
- MNAT1 p.Lys121Arg Uncertain significance Single submitter
- MNAT1 p.Lys55Arg Uncertain significance Single submitter
- MNAT1 p.Met265Val Uncertain significance Single submitter
- MNAT1 p.Pro215Arg Uncertain significance Single submitter
- MNAT1 p.Pro217Leu Uncertain significance Single submitter
- MNAT1 p.Pro237His Uncertain significance Single submitter
- MNAT1 p.Thr222Arg Uncertain significance Single submitter
- MNAT1 p.Val35Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All MNAT1 variants
Benign 1
- p.Ile74= Multiple submitters
Likely benign 1
- p.Leu109Phe Multiple submitters
Uncertain significance 31
- p.Ala244Thr Single submitter ⚠
- p.Ala278Ser Single submitter ⚠
- p.Arg155Gln Single submitter ⚠
- p.Asn111His Single submitter ⚠
- p.Asn129Ser Single submitter ⚠
- p.Asn57Asp Single submitter ⚠
- p.Asp114Tyr Single submitter ⚠
- p.Cys34Phe Single submitter ⚠
- p.Cys34Tyr Single submitter ⚠
- p.Gln144Arg Single submitter ⚠
- p.Gln166Glu Single submitter ⚠
- p.Gln307Lys Single submitter ⚠
- p.Glu145Gly Single submitter ⚠
- p.Glu146Gln Single submitter ⚠
- p.Glu213Gln Single submitter ⚠
- p.Ile174Thr Single submitter ⚠
- p.Ile253Met Single submitter ⚠
- p.Leu175Arg Single submitter ⚠
- p.Leu212Phe Single submitter ⚠
- p.Leu241Pro Single submitter ⚠
- p.Lys121Arg Single submitter ⚠
- p.Lys55Arg Single submitter ⚠
- p.Met265Val Single submitter ⚠
- p.Pro215Arg Single submitter ⚠
- p.Pro217Leu Single submitter ⚠
- p.Pro237His Single submitter ⚠
- p.Thr222Arg Single submitter ⚠
- p.Val23Met Single submitter ⚠
- p.Val260Asp Single submitter ⚠
- p.Val35Ile Single submitter ⚠
- p.Val72Ile Single submitter ⚠