Sugi Variant

Sugi Variant/MNX1

MNX1 — 423 ClinVar variants

All ClinVar germline MNX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 199 flagged for review →

30 Pathogenic · 2 Pathogenic/Likely pathogenic · 15 Likely pathogenic · 9 Conflicting · 15 Benign · 4 Benign/Likely benign · 111 Likely benign · 237 Uncertain significance

Full MNX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 199

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 5

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 149

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 45

The independent predictors disagree with each other — read with care.

All MNX1 variants

Pathogenic 30

Pathogenic/Likely pathogenic 2

Likely pathogenic 15

Conflicting classifications of pathogenicity 9

Benign 15

Benign/Likely benign 4

Likely benign 111

Uncertain significance 237