MOBP — 19 ClinVar variants
All ClinVar germline MOBP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
7 Likely benign · 12 Uncertain significance
Full MOBP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MOBP p.Ala6Thr Uncertain significance Single submitter
-
MOBP p.Pro84Ser
Uncertain significance
Single submitter
MOBP-related disorder
-
MOBP p.Pro87Leu
Uncertain significance
Single submitter
MOBP-related disorder
Predictors split 6
The independent predictors disagree with each other — read with care.
-
MOBP p.Arg172Ser
Uncertain significance
Single submitter
amyotrophic lateral sclerosis
- MOBP p.Gly9Cys Uncertain significance Single submitter
- MOBP p.Phe22Leu Uncertain significance Single submitter
- MOBP p.Phe30Leu Uncertain significance Single submitter
- MOBP p.Thr31Ile Uncertain significance Single submitter
-
MOBP p.Pro121Ser
Likely benign
No assertion criteria
MOBP-related disorder
All MOBP variants
Likely benign 7
- c.207-27G>A Single submitter MOBP-related disorder
- p.99SPPRSERQPR[3] No assertion criteria MOBP-related disorder
- p.Lys96= No assertion criteria MOBP-related disorder
- p.Pro121Ser No assertion criteria MOBP-related disorder ⚠
- p.Pro152= No assertion criteria MOBP-related disorder
- p.Pro80= No assertion criteria MOBP-related disorder
- p.Ser19= No assertion criteria MOBP-related disorder
Uncertain significance 12
- c.206+5G>C Single submitter MOBP-related disorder
- p.Ala64Thr Single submitter
- p.Ala6Thr Single submitter ⚠
- p.Arg172Ser Single submitter amyotrophic lateral sclerosis ⚠
- p.Gly9Cys Single submitter ⚠
- p.Phe22Leu Single submitter ⚠
- p.Phe30Leu Single submitter ⚠
- p.Pro76Arg Single submitter
- p.Pro84Ser Single submitter MOBP-related disorder ⚠
- p.Pro87Leu Single submitter MOBP-related disorder ⚠
- p.Thr31Ile Single submitter ⚠
- c.207-22C>T No assertion criteria MOBP-related disorder