Sugi Variant

Sugi Variant/MOCOS

MOCOS — 525 ClinVar variants

All ClinVar germline MOCOS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 254 flagged for review →

13 Pathogenic · 2 Pathogenic/Likely pathogenic · 27 Likely pathogenic · 13 Conflicting · 59 Benign · 18 Benign/Likely benign · 119 Likely benign · 274 Uncertain significance

Full MOCOS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 254

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 9

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 198

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 198

Predictors split 47

The independent predictors disagree with each other — read with care.

All MOCOS variants

Pathogenic 13

Pathogenic/Likely pathogenic 2

Likely pathogenic 27

Conflicting classifications of pathogenicity 13

Benign 59

Benign/Likely benign 18

Likely benign 119

Uncertain significance 274