MOGAT2 — 78 ClinVar variants
All ClinVar germline MOGAT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
2 Benign · 3 Likely benign · 73 Uncertain significance
Full MOGAT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MOGAT2 p.Ala105Val Uncertain significance Single submitter
- MOGAT2 p.Ala169Ser Uncertain significance Single submitter
- MOGAT2 p.Ala213Thr Uncertain significance Single submitter
- MOGAT2 p.Ala218Glu Uncertain significance Single submitter
- MOGAT2 p.Ala218Thr Uncertain significance Single submitter
- MOGAT2 p.Ala318Thr Uncertain significance Single submitter
- MOGAT2 p.Ala54Val Uncertain significance Single submitter
- MOGAT2 p.Ala5Val Uncertain significance Single submitter
- MOGAT2 p.Ala73Val Uncertain significance Single submitter
- MOGAT2 p.Arg136Cys Uncertain significance Single submitter
- MOGAT2 p.Arg136His Uncertain significance Single submitter
- MOGAT2 p.Arg147Gln Uncertain significance Single submitter
- MOGAT2 p.Arg147Trp Uncertain significance Single submitter
- MOGAT2 p.Arg152Lys Uncertain significance Single submitter
- MOGAT2 p.Arg206Pro Uncertain significance Single submitter
- MOGAT2 p.Arg307Leu Uncertain significance Single submitter
- MOGAT2 p.Arg65Gln Uncertain significance Single submitter
- MOGAT2 p.Cys122Arg Uncertain significance Single submitter
- MOGAT2 p.Glu289Asp Uncertain significance Single submitter
- MOGAT2 p.Glu298Ala Uncertain significance Single submitter
- MOGAT2 p.Gly116Arg Uncertain significance Single submitter
- MOGAT2 p.Gly178Arg Uncertain significance Single submitter
- MOGAT2 p.Gly182Ser Uncertain significance Single submitter
- MOGAT2 p.Gly208Asp Uncertain significance Single submitter
- MOGAT2 p.Gly217Arg Uncertain significance Single submitter
- MOGAT2 p.His138Tyr Uncertain significance Single submitter
- MOGAT2 p.His319Pro Uncertain significance Single submitter
- MOGAT2 p.His330Leu Uncertain significance Single submitter
- MOGAT2 p.Ile235Leu Uncertain significance Single submitter
- MOGAT2 p.Leu121Met Uncertain significance Single submitter
- MOGAT2 p.Leu231Val Uncertain significance Single submitter
- MOGAT2 p.Leu260Phe Uncertain significance Single submitter
- MOGAT2 p.Leu315Pro Uncertain significance Single submitter
- MOGAT2 p.Leu7Phe Uncertain significance Single submitter
- MOGAT2 p.Lys320Arg Uncertain significance Single submitter
- MOGAT2 p.Met156Leu Uncertain significance Single submitter
- MOGAT2 p.Met156Lys Uncertain significance Single submitter
- MOGAT2 p.Phe132Leu Uncertain significance Single submitter
- MOGAT2 p.Phe226Leu Uncertain significance Single submitter
- MOGAT2 p.Phe226Val Uncertain significance Single submitter
- MOGAT2 p.Pro10Ser Uncertain significance Single submitter
- MOGAT2 p.Ser130Leu Uncertain significance Single submitter
- MOGAT2 p.Thr123Ser Uncertain significance Single submitter
- MOGAT2 p.Thr215Ala Uncertain significance Single submitter
- MOGAT2 p.Thr293Ala Uncertain significance Single submitter
- MOGAT2 p.Thr78Ile Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- MOGAT2 p.Arg101Trp Uncertain significance Single submitter
- MOGAT2 p.Arg277Cys Uncertain significance Single submitter
- MOGAT2 p.Arg278Trp Uncertain significance Single submitter
- MOGAT2 p.Arg69Gln Uncertain significance Single submitter
- MOGAT2 p.Arg69Trp Uncertain significance Single submitter
- MOGAT2 p.Gln234His Uncertain significance Single submitter
- MOGAT2 p.Gly134Ser Uncertain significance Single submitter
- MOGAT2 p.Gly176Cys Uncertain significance Single submitter
- MOGAT2 p.His108Tyr Uncertain significance Single submitter
- MOGAT2 p.His319Gln Uncertain significance Single submitter
- MOGAT2 p.Leu331Val Uncertain significance Single submitter
- MOGAT2 p.Phe38Tyr Uncertain significance Single submitter
- MOGAT2 p.Pro196Thr Uncertain significance Single submitter
- MOGAT2 p.Pro279Thr Uncertain significance Single submitter
- MOGAT2 p.Pro64Thr Uncertain significance Single submitter
- MOGAT2 p.Ser157Phe Uncertain significance Single submitter
- MOGAT2 p.Ser167Gly Uncertain significance Single submitter
- MOGAT2 p.Ser297Leu Uncertain significance Single submitter
- MOGAT2 p.Thr200Met Uncertain significance Single submitter
- MOGAT2 p.Thr282Ala Uncertain significance Single submitter
- MOGAT2 p.Val161Ala Uncertain significance Single submitter
All MOGAT2 variants
Benign 2
- p.Thr35Ile Multiple submitters
- p.Val210Ile Single submitter
Likely benign 3
- p.Arg65Trp Single submitter
- p.Thr50Ser Single submitter
- p.Val115Ala Single submitter
Uncertain significance 73
- p.Ala105Val Single submitter ⚠
- p.Ala169Ser Single submitter ⚠
- p.Ala213Thr Single submitter ⚠
- p.Ala218Glu Single submitter ⚠
- p.Ala218Thr Single submitter ⚠
- p.Ala318Thr Single submitter ⚠
- p.Ala54Val Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Ala73Val Single submitter ⚠
- p.Arg101Trp Single submitter ⚠
- p.Arg136Cys Single submitter ⚠
- p.Arg136His Single submitter ⚠
- p.Arg147Gln Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Arg152Lys Single submitter ⚠
- p.Arg206Pro Single submitter ⚠
- p.Arg264His Single submitter
- p.Arg277Cys Single submitter ⚠
- p.Arg278Trp Single submitter ⚠
- p.Arg307Leu Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Arg69Trp Single submitter ⚠
- p.Cys122Arg Single submitter ⚠
- p.Gln234His Single submitter ⚠
- p.Glu289Asp Single submitter ⚠
- p.Glu298Ala Single submitter ⚠
- p.Gly116Arg Single submitter ⚠
- p.Gly134Ser Single submitter ⚠
- p.Gly176Cys Single submitter ⚠
- p.Gly178Arg Single submitter ⚠
- p.Gly182Ser Single submitter ⚠
- p.Gly208Asp Single submitter ⚠
- p.Gly217Arg Single submitter ⚠
- p.His108Tyr Single submitter ⚠
- p.His138Tyr Single submitter ⚠
- p.His305Tyr Single submitter
- p.His319Gln Single submitter ⚠
- p.His319Pro Single submitter ⚠
- p.His330Leu Single submitter ⚠
- p.Ile235Leu Single submitter ⚠
- p.Ile325Asn Single submitter
- p.Leu121Met Single submitter ⚠
- p.Leu231Val Single submitter ⚠
- p.Leu260Phe Single submitter ⚠
- p.Leu315Pro Single submitter ⚠
- p.Leu331Val Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Lys320Arg Single submitter ⚠
- p.Met156Leu Single submitter ⚠
- p.Met156Lys Single submitter ⚠
- p.Phe132Leu Single submitter ⚠
- p.Phe226Leu Single submitter ⚠
- p.Phe226Val Single submitter ⚠
- p.Phe38Tyr Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro196Thr Single submitter ⚠
- p.Pro279Thr Single submitter ⚠
- p.Pro296Thr Single submitter
- p.Pro64Thr Single submitter ⚠
- p.Ser130Leu Single submitter ⚠
- p.Ser157Phe Single submitter ⚠
- p.Ser167Gly Single submitter ⚠
- p.Ser297Leu Single submitter ⚠
- p.Thr123Ser Single submitter ⚠
- p.Thr200Met Single submitter ⚠
- p.Thr215Ala Single submitter ⚠
- p.Thr282Ala Single submitter ⚠
- p.Thr293Ala Single submitter ⚠
- p.Thr78Ile Single submitter ⚠
- p.Thr94Asn Single submitter
- p.Tyr269Cys Single submitter
- p.Val161Ala Single submitter ⚠