MOK — 75 ClinVar variants
All ClinVar germline MOK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Benign · 4 Likely benign · 70 Uncertain significance
Full MOK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MOK p.Ala196Ser Uncertain significance Single submitter
- MOK p.Ala222Thr Uncertain significance Single submitter
- MOK p.Ala276Thr Uncertain significance Single submitter
- MOK p.Arg150Trp Uncertain significance Single submitter
- MOK p.Arg165Cys Uncertain significance Single submitter
- MOK p.Arg168Trp Uncertain significance Single submitter
- MOK p.Arg294Trp Uncertain significance Single submitter
- MOK p.Arg300Ser Uncertain significance Single submitter
- MOK p.Arg337Gly Uncertain significance Single submitter
- MOK p.Arg38Pro Uncertain significance Single submitter
- MOK p.Arg415Gln Uncertain significance Single submitter
- MOK p.Asn206Ser Uncertain significance Single submitter
- MOK p.Asn28Ser Uncertain significance Single submitter
- MOK p.Asp145Asn Uncertain significance Single submitter
- MOK p.Gln281Arg Uncertain significance Single submitter
- MOK p.Gln286Arg Uncertain significance Single submitter
- MOK p.Gln406Arg Uncertain significance Single submitter
- MOK p.Glu171Asp Uncertain significance Single submitter
- MOK p.Glu194Lys Uncertain significance Single submitter
- MOK p.Glu312Lys Uncertain significance Single submitter
- MOK p.Gly356Ala Uncertain significance Single submitter
- MOK p.Gly373Arg Uncertain significance Single submitter
- MOK p.Gly417Asp Uncertain significance Single submitter
- MOK p.Gly417Ser Uncertain significance Single submitter
- MOK p.His60Tyr Uncertain significance Single submitter
- MOK p.Ile134Val Uncertain significance Single submitter
- MOK p.Ile218Val Uncertain significance Single submitter
- MOK p.Ile413Thr Uncertain significance Single submitter
- MOK p.Ile413Val Uncertain significance Single submitter
- MOK p.Ile42Val Uncertain significance Single submitter
- MOK p.Leu352Pro Uncertain significance Single submitter
- MOK p.Lys351Gln Uncertain significance Single submitter
- MOK p.Lys402Arg Uncertain significance Single submitter
- MOK p.Met109Leu Uncertain significance Single submitter
- MOK p.Met87Val Uncertain significance Single submitter
- MOK p.Phe146Ser Uncertain significance Single submitter
- MOK p.Phe202Ser Uncertain significance Single submitter
- MOK p.Phe241Cys Uncertain significance Single submitter
- MOK p.Pro200Ser Uncertain significance Single submitter
- MOK p.Pro256Thr Uncertain significance Single submitter
- MOK p.Pro305Leu Uncertain significance Single submitter
- MOK p.Pro308Ser Uncertain significance Single submitter
- MOK p.Pro311Ser Uncertain significance Single submitter
- MOK p.Pro381Arg Uncertain significance Single submitter
- MOK p.Pro385His Uncertain significance Single submitter
- MOK p.Pro397Leu Uncertain significance Single submitter
- MOK p.Ser232Leu Uncertain significance Single submitter
- MOK p.Ser355Leu Uncertain significance Single submitter
- MOK p.Ser362Phe Uncertain significance Single submitter
- MOK p.Thr14Met Uncertain significance Single submitter
- MOK p.Thr159Met Uncertain significance Single submitter
- MOK p.Thr227Ser Uncertain significance Single submitter
- MOK p.Thr367Met Uncertain significance Single submitter
- MOK p.Tyr153His Uncertain significance Single submitter
- MOK p.Val266Ala Uncertain significance Single submitter
- MOK p.Val358Gly Uncertain significance Single submitter
- MOK p.Val45Phe Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- MOK p.Lys137Asn Benign Multiple submitters
- MOK p.Arg150Gln Uncertain significance Single submitter
- MOK p.Arg56His Uncertain significance Single submitter
- MOK p.Glu68Lys Uncertain significance Single submitter
- MOK p.Lys5Glu Uncertain significance Single submitter
- MOK p.Met109Thr Uncertain significance Single submitter
- MOK p.Pro59Leu Uncertain significance Single submitter
- MOK p.Ser260Phe Uncertain significance Single submitter
- MOK p.Ser41Gly Uncertain significance Single submitter
- MOK p.Tyr153Ser Uncertain significance Single submitter
- MOK p.Val45Ala Uncertain significance Single submitter
All MOK variants
Benign 1
- p.Lys137Asn Multiple submitters ⚠
Likely benign 4
- p.Ala275Thr Single submitter
- p.Asn47Ser Single submitter
- p.Ile162= Single submitter
- p.Pro311Leu Single submitter
Uncertain significance 70
- p.Ala196Ser Single submitter ⚠
- p.Ala222Thr Single submitter ⚠
- p.Ala276Thr Single submitter ⚠
- p.Arg150Gln Single submitter ⚠
- p.Arg150Trp Single submitter ⚠
- p.Arg165Cys Single submitter ⚠
- p.Arg168Trp Single submitter ⚠
- p.Arg294Trp Single submitter ⚠
- p.Arg300Ser Single submitter ⚠
- p.Arg337Gly Single submitter ⚠
- p.Arg38Pro Single submitter ⚠
- p.Arg415Gln Single submitter ⚠
- p.Arg56His Single submitter ⚠
- p.Asn206Ser Single submitter ⚠
- p.Asn28Ser Single submitter ⚠
- p.Asn62Asp Single submitter
- p.Asp145Asn Single submitter ⚠
- p.Gln281Arg Single submitter ⚠
- p.Gln286Arg Single submitter ⚠
- p.Gln406Arg Single submitter ⚠
- p.Glu171Asp Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu312Lys Single submitter ⚠
- p.Glu68Lys Single submitter ⚠
- p.Gly356Ala Single submitter ⚠
- p.Gly373Arg Single submitter ⚠
- p.Gly417Asp Single submitter ⚠
- p.Gly417Ser Single submitter ⚠
- p.His60Tyr Single submitter ⚠
- p.Ile105Ser Single submitter
- p.Ile134Val Single submitter ⚠
- p.Ile211fs Single submitter mucopolysaccharidosis type 3D
- p.Ile218Val Single submitter ⚠
- p.Ile413Thr Single submitter ⚠
- p.Ile413Val Single submitter ⚠
- p.Ile42Val Single submitter ⚠
- p.Leu352Pro Single submitter ⚠
- p.Lys351Gln Single submitter ⚠
- p.Lys402Arg Single submitter ⚠
- p.Lys5Glu Single submitter ⚠
- p.Met109Leu Single submitter ⚠
- p.Met109Thr Single submitter ⚠
- p.Met87Val Single submitter ⚠
- p.Phe146Ser Single submitter ⚠
- p.Phe202Ser Single submitter ⚠
- p.Phe241Cys Single submitter ⚠
- p.Pro200Ser Single submitter ⚠
- p.Pro256Thr Single submitter ⚠
- p.Pro305Leu Single submitter ⚠
- p.Pro308Ser Single submitter ⚠
- p.Pro311Ser Single submitter ⚠
- p.Pro381Arg Single submitter ⚠
- p.Pro385His Single submitter ⚠
- p.Pro397Leu Single submitter ⚠
- p.Pro59Leu Single submitter ⚠
- p.Ser232Leu Single submitter ⚠
- p.Ser260Phe Single submitter ⚠
- p.Ser355Leu Single submitter ⚠
- p.Ser362Phe Single submitter ⚠
- p.Ser41Gly Single submitter ⚠
- p.Thr14Met Single submitter ⚠
- p.Thr159Met Single submitter ⚠
- p.Thr227Ser Single submitter ⚠
- p.Thr367Met Single submitter ⚠
- p.Tyr153His Single submitter ⚠
- p.Tyr153Ser Single submitter ⚠
- p.Val266Ala Single submitter ⚠
- p.Val358Gly Single submitter ⚠
- p.Val45Ala Single submitter ⚠
- p.Val45Phe Single submitter ⚠