MON2 — 158 ClinVar variants

All ClinVar germline MON2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 145 flagged for review →

1 Benign · 4 Likely benign · 153 Uncertain significance

Full MON2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 145

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 108

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 37

The independent predictors disagree with each other — read with care.

All MON2 variants

Benign 1

c.2466+10_2466+11del Single submitter

Likely benign 4

p.Arg860= Single submitter
p.Asn874Ser Single submitter
p.Pro868= Single submitter
p.Val637Ile Single submitter

Uncertain significance 153

p.Ala1282Gly Single submitter ⚠
p.Ala1334Ser Single submitter ⚠
p.Ala1366Val Single submitter ⚠
p.Ala1709Pro Single submitter ⚠
p.Ala590Thr Single submitter ⚠
p.Ala687Val Single submitter ⚠
p.Arg1010Gln Single submitter ⚠
p.Arg1037Cys Single submitter ⚠
p.Arg1130Thr Single submitter ⚠
p.Arg1211Ile Single submitter ⚠
p.Arg1211Lys Single submitter ⚠
p.Arg1478Trp Single submitter ⚠
p.Arg152Gln Single submitter ⚠
p.Arg1711Thr Single submitter ⚠
p.Arg204Lys Single submitter ⚠
p.Arg352Gln Single submitter ⚠
p.Arg387His Single submitter ⚠
p.Arg497Ser Single submitter ⚠
p.Arg52Gln Single submitter ⚠
p.Arg830Gln Single submitter ⚠
p.Asn1097Ser Single submitter ⚠
p.Asn1127Ser Single submitter ⚠
p.Asn1159Ser Single submitter ⚠
p.Asn1238Asp Single submitter ⚠
p.Asn1238His Single submitter ⚠
p.Asn228Thr Single submitter ⚠
p.Asn748Ser Single submitter ⚠
p.Asn850Ser Single submitter ⚠
p.Asp1183Tyr Single submitter ⚠
p.Asp1362His Single submitter ⚠
p.Asp532Asn Single submitter ⚠
p.Asp879Asn Single submitter
p.Cys1372Tyr Single submitter ⚠
p.Cys942Ser Single submitter ⚠
p.Gln1151Leu Single submitter
p.Gln1332Arg Single submitter ⚠
p.Gln1528His Single submitter ⚠
p.Gln18His Single submitter ⚠
p.Gln825Arg Single submitter ⚠
p.Gln91Arg Single submitter ⚠
p.Gln981Arg Single submitter ⚠
p.Glu1233Lys Single submitter ⚠
p.Glu1325Lys Single submitter ⚠
p.Glu1351Gly Single submitter ⚠
p.Glu1369Gly Single submitter ⚠
p.Glu1520Asp Single submitter ⚠
p.Glu1525Lys Single submitter ⚠
p.Glu1716Gly Single submitter ⚠
p.Glu994Asp Single submitter ⚠
p.Gly1053Ser Single submitter ⚠
p.Gly1095Asp Single submitter ⚠
p.Gly42Arg Single submitter ⚠
p.Gly438Ser Single submitter ⚠
p.Gly461Cys Single submitter
p.Gly482Asp Single submitter ⚠
p.Gly639Cys Single submitter
p.Gly725Arg Single submitter ⚠
p.His1074Arg Single submitter ⚠
p.His688Arg Single submitter ⚠
p.His690Arg Single submitter ⚠
p.His851Asp Single submitter ⚠
p.His96Tyr Single submitter ⚠
p.Ile1052Thr Single submitter ⚠
p.Ile1091Thr Single submitter ⚠
p.Ile1279Val Single submitter ⚠
p.Ile1319Phe Single submitter ⚠
p.Ile1346Val Single submitter ⚠
p.Ile1472Thr Single submitter ⚠
p.Ile1506Met Single submitter ⚠
p.Ile1513Leu Single submitter ⚠
p.Ile1530Thr Single submitter ⚠
p.Ile1558Val Single submitter ⚠
p.Ile1572Thr Single submitter ⚠
p.Ile1603Val Single submitter ⚠
p.Ile1623Lys Single submitter ⚠
p.Ile1643Leu Single submitter ⚠
p.Ile309Val Single submitter ⚠
p.Ile677Thr Single submitter ⚠
p.Ile90Val Single submitter ⚠
p.Leu1237Trp Single submitter ⚠
p.Leu1264Val Single submitter ⚠
p.Leu1364Phe Single submitter ⚠
p.Leu1414Ser Single submitter ⚠
p.Leu1466Phe Single submitter ⚠
p.Leu1470Val Single submitter ⚠
p.Leu495Phe Single submitter ⚠
p.Leu630Pro Single submitter ⚠
p.Leu686Val Single submitter ⚠
p.Lys1504Glu Single submitter ⚠
p.Lys1543Glu Single submitter ⚠
p.Lys81Arg Single submitter ⚠
p.Lys999Glu Single submitter ⚠
p.Met1205Val Single submitter ⚠
p.Met311Ile Single submitter ⚠
p.Met432Val Single submitter ⚠
p.Met485Val Single submitter ⚠
p.Met540Thr Single submitter ⚠
p.Met643Thr Single submitter ⚠
p.Met806Ile Single submitter ⚠
p.Met806Lys Single submitter ⚠
p.Met806Val Single submitter ⚠
p.Met940Val Single submitter ⚠
p.Phe1367Ser Single submitter ⚠
p.Phe1500Ile Single submitter ⚠
p.Phe267Leu Single submitter ⚠
p.Pro1196Ser Single submitter ⚠
p.Pro1228Ala Single submitter ⚠
p.Pro1350Thr Single submitter ⚠
p.Pro1398Leu Single submitter ⚠
p.Pro1633Leu Single submitter ⚠
p.Pro258Leu Single submitter ⚠
p.Pro301Gln Single submitter
p.Pro404Leu Single submitter ⚠
p.Pro404Ser Single submitter ⚠
p.Pro480Thr Single submitter
p.Pro938Leu Single submitter ⚠
p.Ser1225Ala Single submitter ⚠
p.Ser1305Arg Single submitter ⚠
p.Ser1482Ala Single submitter ⚠
p.Ser1579Pro Single submitter ⚠
p.Ser1629Cys Single submitter ⚠
p.Ser1687Pro Single submitter ⚠
p.Ser1710Ala Single submitter ⚠
p.Ser294Gly Single submitter ⚠
p.Ser527Leu Single submitter ⚠
p.Ser5Gly Single submitter ⚠
p.Ser646Asn Single submitter ⚠
p.Ser841Phe Single submitter ⚠
p.Ser856Pro Single submitter ⚠
p.Thr1114Met Single submitter ⚠
p.Thr134Ala Single submitter ⚠
p.Thr174Ile Single submitter ⚠
p.Thr440Ala Single submitter ⚠
p.Thr478Ala Single submitter ⚠
p.Thr606Ile Single submitter ⚠
p.Thr629Ala Single submitter ⚠
p.Thr629Ile Single submitter ⚠
p.Thr737Ile Single submitter ⚠
p.Thr801Ala Single submitter ⚠
p.Thr840Ile Single submitter
p.Trp1143Cys Single submitter ⚠
p.Tyr1377Cys Single submitter
p.Tyr1622Ser Single submitter ⚠
p.Tyr617His Single submitter ⚠
p.Val1179Ala Single submitter ⚠
p.Val1445Leu Single submitter ⚠
p.Val1527Ile Single submitter ⚠
p.Val1712Ile Single submitter ⚠
p.Val173Ile Single submitter ⚠
p.Val173Phe Single submitter ⚠
p.Val260Phe Single submitter ⚠
p.Val621Ala Single submitter ⚠
p.Val951Ile Single submitter ⚠