MORF4L1 — 30 ClinVar variants
All ClinVar germline MORF4L1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Likely benign · 29 Uncertain significance
Full MORF4L1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MORF4L1 c.156-1064C>T Uncertain significance Single submitter
- MORF4L1 c.156-1067T>A Uncertain significance Single submitter
- MORF4L1 c.156-1074C>A Uncertain significance Single submitter
- MORF4L1 c.156-1100C>G Uncertain significance Single submitter
- MORF4L1 c.156-1115C>A Uncertain significance Single submitter
- MORF4L1 c.156-1124A>G Uncertain significance Single submitter
- MORF4L1 c.156-1138G>T Uncertain significance Single submitter
- MORF4L1 c.156-1142C>A Uncertain significance Single submitter
- MORF4L1 c.156-1154G>A Uncertain significance Single submitter
- MORF4L1 c.156-1155C>T Uncertain significance Single submitter
- MORF4L1 c.156-1163G>C Uncertain significance Single submitter
- MORF4L1 c.156-1167G>T Uncertain significance Single submitter
- MORF4L1 p.Ala260Val Uncertain significance Single submitter
- MORF4L1 p.Asn289Ser Uncertain significance Single submitter
- MORF4L1 p.Gly123Ala Uncertain significance Single submitter
- MORF4L1 p.Ile35Val Uncertain significance Single submitter
- MORF4L1 p.Met151Thr Uncertain significance Single submitter
- MORF4L1 p.Phe182Cys Uncertain significance Single submitter
- MORF4L1 p.Ser127Gly Uncertain significance Single submitter
- MORF4L1 p.Thr207Ala Uncertain significance Single submitter
- MORF4L1 p.Val66Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- MORF4L1 c.156-1059A>C Uncertain significance Single submitter
- MORF4L1 p.Arg204Cys Uncertain significance Single submitter
- MORF4L1 p.Lys10Glu Uncertain significance Single submitter
- MORF4L1 p.Pro58Leu Uncertain significance Single submitter
- MORF4L1 p.Thr143Pro Uncertain significance Single submitter
- MORF4L1 p.Val40Leu Uncertain significance Single submitter
All MORF4L1 variants
Likely benign 1
- c.156-1143T>A Single submitter
Uncertain significance 29
- c.156-1059A>C Single submitter ⚠
- c.156-1064C>T Single submitter ⚠
- c.156-1067T>A Single submitter ⚠
- c.156-1074C>A Single submitter ⚠
- c.156-1100C>G Single submitter ⚠
- c.156-1115C>A Single submitter ⚠
- c.156-1124A>G Single submitter ⚠
- c.156-1138G>T Single submitter ⚠
- c.156-1142C>A Single submitter ⚠
- c.156-1154G>A Single submitter ⚠
- c.156-1155C>T Single submitter ⚠
- c.156-1163G>C Single submitter ⚠
- c.156-1167G>T Single submitter ⚠
- c.156-1174_156-1173insT Single submitter
- p.Ala260Val Single submitter ⚠
- p.Arg204Cys Single submitter ⚠
- p.Asn289Ser Single submitter ⚠
- p.Asn301Ser Single submitter
- p.Gly123Ala Single submitter ⚠
- p.Ile35Val Single submitter ⚠
- p.Lys10Glu Single submitter ⚠
- p.Met151Thr Single submitter ⚠
- p.Phe182Cys Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Ser127Gly Single submitter ⚠
- p.Thr143Pro Single submitter ⚠
- p.Thr207Ala Single submitter ⚠
- p.Val40Leu Single submitter ⚠
- p.Val66Ala Single submitter ⚠