MPC2 — 10 ClinVar variants
All ClinVar germline MPC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
10 Uncertain significance
Full MPC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MPC2 p.Ala11Pro Uncertain significance Single submitter
- MPC2 p.Ile47Val Uncertain significance Single submitter
- MPC2 p.Leu111Val Uncertain significance Single submitter
- MPC2 p.Leu31Ser Uncertain significance Single submitter
- MPC2 p.Lys27Arg Uncertain significance Single submitter
- MPC2 p.Met76Thr Uncertain significance Single submitter
- MPC2 p.Ser68Arg Uncertain significance Single submitter
- MPC2 p.Ser86Leu Uncertain significance Single submitter
- MPC2 p.Thr12Ala Uncertain significance Single submitter
- MPC2 p.Val103Met Uncertain significance Single submitter
All MPC2 variants
Uncertain significance 10
- p.Ala11Pro Single submitter ⚠
- p.Ile47Val Single submitter ⚠
- p.Leu111Val Single submitter ⚠
- p.Leu31Ser Single submitter ⚠
- p.Lys27Arg Single submitter ⚠
- p.Met76Thr Single submitter ⚠
- p.Ser68Arg Single submitter ⚠
- p.Ser86Leu Single submitter ⚠
- p.Thr12Ala Single submitter ⚠
- p.Val103Met Single submitter ⚠