MPG — 70 ClinVar variants
All ClinVar germline MPG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
2 Benign · 4 Likely benign · 64 Uncertain significance
Full MPG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MPG p.Val280Ile Uncertain significance Multiple submitters
- MPG p.Ala200Thr Uncertain significance Single submitter
- MPG p.Ala21Pro Uncertain significance Single submitter
- MPG p.Ala221Ser Uncertain significance Single submitter
- MPG p.Ala255Val Uncertain significance Single submitter
- MPG p.Ala96Glu Uncertain significance Single submitter
- MPG p.Arg105Gln Uncertain significance Single submitter
- MPG p.Arg196Gly Uncertain significance Single submitter
- MPG p.Arg19Gly Uncertain significance Single submitter
- MPG p.Arg207His Uncertain significance Single submitter
- MPG p.Arg241Cys Uncertain significance Single submitter
- MPG p.Arg256Trp Uncertain significance Single submitter
- MPG p.Arg267Trp Uncertain significance Single submitter
- MPG p.Arg53Trp Uncertain significance Single submitter
- MPG p.Arg55His Uncertain significance Single submitter
- MPG p.Arg80Gln Uncertain significance Single submitter
- MPG p.Asp230Asn Uncertain significance Single submitter
- MPG p.Asp45His Uncertain significance Single submitter
- MPG p.Asp45Val Uncertain significance Single submitter
- MPG p.Asp87Ala Uncertain significance Single submitter
- MPG p.Cys10Phe Uncertain significance Single submitter
- MPG p.Gln228His Uncertain significance Single submitter
- MPG p.Gln233Lys Uncertain significance Single submitter
- MPG p.Glu126Gly Uncertain significance Single submitter
- MPG p.Glu245Asp Uncertain significance Single submitter
- MPG p.Gly124Trp Uncertain significance Single submitter
- MPG p.Gly158Ser Uncertain significance Single submitter
- MPG p.Gly158Val Uncertain significance Single submitter
- MPG p.Gly169Ala Uncertain significance Single submitter
- MPG p.Gly260Ser Uncertain significance Single submitter
- MPG p.His27Asn Uncertain significance Single submitter
- MPG p.Ile116Val Uncertain significance Single submitter
- MPG p.Ile155Phe Uncertain significance Single submitter
- MPG p.Leu123Met Uncertain significance Single submitter
- MPG p.Leu123Val Uncertain significance Single submitter
- MPG p.Leu83Met Uncertain significance Single submitter
- MPG p.Met188Thr Uncertain significance Single submitter
- MPG p.Pro20Ala Uncertain significance Single submitter
- MPG p.Pro249Leu Uncertain significance Single submitter
- MPG p.Pro269Leu Uncertain significance Single submitter
- MPG p.Ser68Gly Uncertain significance Single submitter
- MPG p.Thr119Pro Uncertain significance Single submitter
- MPG p.Thr187Ile Uncertain significance Single submitter
- MPG p.Thr62Ile Uncertain significance Single submitter
- MPG p.Trp238Cys Uncertain significance Single submitter
- MPG p.Tyr157Cys Uncertain significance Single submitter
- MPG p.Val283Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- MPG p.Arg104Gln Uncertain significance Single submitter
- MPG p.Arg202His Uncertain significance Single submitter
- MPG p.Arg207Leu Uncertain significance Single submitter
- MPG p.Arg271His Uncertain significance Single submitter
- MPG p.Arg275Pro Uncertain significance Single submitter
- MPG p.Arg275Trp Uncertain significance Single submitter
- MPG p.Glu183Lys Uncertain significance Single submitter
- MPG p.Glu208Lys Uncertain significance Single submitter
- MPG p.Leu112Phe Uncertain significance Single submitter
- MPG p.Lys205Glu Uncertain significance Single submitter
- MPG p.Lys268Asn Uncertain significance Single submitter
- MPG p.Met163Thr Uncertain significance Single submitter
All MPG variants
Likely benign 4
- p.Ala172= Single submitter
- p.Arg256= Single submitter
- p.Pro20Leu Single submitter
- p.Val259= Single submitter
Uncertain significance 64
- p.Val280Ile Multiple submitters ⚠
- p.Ala200Thr Single submitter ⚠
- p.Ala21Pro Single submitter ⚠
- p.Ala221Ser Single submitter ⚠
- p.Ala255Val Single submitter ⚠
- p.Ala96Glu Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg105Gln Single submitter ⚠
- p.Arg196Gly Single submitter ⚠
- p.Arg19Gly Single submitter ⚠
- p.Arg202His Single submitter ⚠
- p.Arg207His Single submitter ⚠
- p.Arg207Leu Single submitter ⚠
- p.Arg241Cys Single submitter ⚠
- p.Arg256Trp Single submitter ⚠
- p.Arg267Trp Single submitter ⚠
- p.Arg271His Single submitter ⚠
- p.Arg275Pro Single submitter ⚠
- p.Arg275Trp Single submitter ⚠
- p.Arg53Trp Single submitter ⚠
- p.Arg55His Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Asp230Asn Single submitter ⚠
- p.Asp45His Single submitter ⚠
- p.Asp45Val Single submitter ⚠
- p.Asp87Ala Single submitter ⚠
- p.Cys10Phe Single submitter ⚠
- p.Gln228His Single submitter ⚠
- p.Gln233Lys Single submitter ⚠
- p.Glu126Gly Single submitter ⚠
- p.Glu183Lys Single submitter ⚠
- p.Glu208Lys Single submitter ⚠
- p.Glu245Asp Single submitter ⚠
- p.Gly124Trp Single submitter ⚠
- p.Gly158Ser Single submitter ⚠
- p.Gly158Val Single submitter ⚠
- p.Gly169Ala Single submitter ⚠
- p.Gly169Val Single submitter
- p.Gly260Ser Single submitter ⚠
- p.His27Asn Single submitter ⚠
- p.Ile116Val Single submitter ⚠
- p.Ile155Phe Single submitter ⚠
- p.Leu112Phe Single submitter ⚠
- p.Leu123Met Single submitter ⚠
- p.Leu123Val Single submitter ⚠
- p.Leu83Met Single submitter ⚠
- p.Leu93fs Single submitter MPG-related condition
- p.Lys205Glu Single submitter ⚠
- p.Lys268Asn Single submitter ⚠
- p.Met163Thr Single submitter ⚠
- p.Met188Thr Single submitter ⚠
- p.Pro20Ala Single submitter ⚠
- p.Pro249Leu Single submitter ⚠
- p.Pro269Leu Single submitter ⚠
- p.Ser214Cys Single submitter
- p.Ser68Gly Single submitter ⚠
- p.Thr119Pro Single submitter ⚠
- p.Thr150Asn Single submitter
- p.Thr187Ile Single submitter ⚠
- p.Thr62Ile Single submitter ⚠
- p.Trp238Cys Single submitter ⚠
- p.Tyr157Cys Single submitter ⚠
- p.Val117Met Single submitter
- p.Val283Ile Single submitter ⚠