MPHOSPH6 — 28 ClinVar variants
All ClinVar germline MPHOSPH6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
2 Benign · 2 Likely benign · 24 Uncertain significance
Full MPHOSPH6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MPHOSPH6 p.Glu53Gln Uncertain significance Multiple submitters
- MPHOSPH6 p.Ala136Thr Uncertain significance Single submitter
- MPHOSPH6 p.Ala151Thr Uncertain significance Single submitter
- MPHOSPH6 p.Ala151Val Uncertain significance Single submitter
- MPHOSPH6 p.Asn143Ser Uncertain significance Single submitter
- MPHOSPH6 p.Asp145Gly Uncertain significance Single submitter
- MPHOSPH6 p.Gln30Lys Uncertain significance Single submitter
- MPHOSPH6 p.Glu55Gln Uncertain significance Single submitter
- MPHOSPH6 p.Glu83Asp Uncertain significance Single submitter
- MPHOSPH6 p.Glu99Lys Uncertain significance Single submitter
- MPHOSPH6 p.Gly126Arg Uncertain significance Single submitter
- MPHOSPH6 p.Leu23Val Uncertain significance Single submitter
- MPHOSPH6 p.Leu71His Uncertain significance Single submitter
- MPHOSPH6 p.Thr104Arg Uncertain significance Single submitter
- MPHOSPH6 p.Thr147Ile Uncertain significance Single submitter
- MPHOSPH6 p.Tyr45Cys Uncertain significance Single submitter
- MPHOSPH6 p.Val100Leu Uncertain significance Single submitter
- MPHOSPH6 p.Val122Met Uncertain significance Single submitter
- MPHOSPH6 p.Val84Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All MPHOSPH6 variants
Benign 2
- p.Ala97= Multiple submitters
- p.Asp134Gly Multiple submitters
Likely benign 2
- p.Arg131Lys Single submitter
- p.Leu66= Single submitter
Uncertain significance 24
- p.Glu53Gln Multiple submitters ⚠
- p.Ala136Thr Single submitter ⚠
- p.Ala151Thr Single submitter ⚠
- p.Ala151Val Single submitter ⚠
- p.Asn143Ser Single submitter ⚠
- p.Asp108Val Single submitter ⚠
- p.Asp141Ala Single submitter ⚠
- p.Asp145Gly Single submitter ⚠
- p.Asp24Glu Single submitter ⚠
- p.Gln30Lys Single submitter ⚠
- p.Glu55Gln Single submitter ⚠
- p.Glu83Asp Single submitter ⚠
- p.Glu99Lys Single submitter ⚠
- p.Gly126Arg Single submitter ⚠
- p.Leu23Val Single submitter ⚠
- p.Leu71His Single submitter ⚠
- p.Lys54Ile Single submitter
- p.Thr104Arg Single submitter ⚠
- p.Thr147Ile Single submitter ⚠
- p.Tyr45Cys Single submitter ⚠
- p.Val100Leu Single submitter ⚠
- p.Val122Leu Single submitter ⚠
- p.Val122Met Single submitter ⚠
- p.Val84Ile Single submitter ⚠