Sugi Variant

Sugi Variant/MRAS

MRAS — 258 ClinVar variants

All ClinVar germline MRAS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →

5 Likely pathogenic · 4 Conflicting · 11 Benign · 9 Benign/Likely benign · 108 Likely benign · 121 Uncertain significance

Full MRAS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 93

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 71

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 21

The independent predictors disagree with each other — read with care.

All MRAS variants

Likely pathogenic 5

Conflicting classifications of pathogenicity 4

Benign 11

Benign/Likely benign 9

  • p.Gly22= Multiple submitters Inborn genetic diseases
  • p.His102= Multiple submitters Inborn genetic diseases
  • p.Ile110= Multiple submitters Inborn genetic diseases
  • p.Ile175= Multiple submitters Inborn genetic diseases
  • p.Leu123= Multiple submitters Inborn genetic diseases
  • p.Leu66= Multiple submitters Inborn genetic diseases
  • p.Lys97= Multiple submitters Inborn genetic diseases
  • p.Pro180= Multiple submitters Inborn genetic diseases
  • p.Thr84= Multiple submitters Inborn genetic diseases

Likely benign 108

Uncertain significance 121