MRGPRX1 — 73 ClinVar variants
All ClinVar germline MRGPRX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
2 Benign · 19 Likely benign · 52 Uncertain significance
Full MRGPRX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRGPRX1 p.Ala182Ser Uncertain significance Single submitter
- MRGPRX1 p.Arg79Cys Uncertain significance Single submitter
- MRGPRX1 p.Asp169His Uncertain significance Single submitter
- MRGPRX1 p.Asp72Glu Uncertain significance Single submitter
- MRGPRX1 p.Glu321Gln Uncertain significance Single submitter
- MRGPRX1 p.Gly162Asp Uncertain significance Single submitter
- MRGPRX1 p.Gly317Arg Uncertain significance Single submitter
- MRGPRX1 p.Ile185Phe Uncertain significance Single submitter
- MRGPRX1 p.Ile65Val Uncertain significance Single submitter
- MRGPRX1 p.Ile90Thr Uncertain significance Single submitter
- MRGPRX1 p.Phe165Leu Uncertain significance Single submitter
- MRGPRX1 p.Pro14Ser Uncertain significance Single submitter
- MRGPRX1 p.Pro3Ala Uncertain significance Single submitter
- MRGPRX1 p.Ser86Ile Uncertain significance Single submitter
- MRGPRX1 p.Ser89Asn Uncertain significance Single submitter
- MRGPRX1 p.Thr43Ile Uncertain significance Single submitter
- MRGPRX1 p.Val181Ile Uncertain significance Single submitter
- MRGPRX1 p.Val244Met Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- MRGPRX1 p.Arg55Leu Benign Multiple submitters
- MRGPRX1 p.Ala115Gly Uncertain significance Single submitter
- MRGPRX1 p.Ala70Ser Uncertain significance Single submitter
- MRGPRX1 p.Arg120Cys Uncertain significance Single submitter
- MRGPRX1 p.Arg134Leu Uncertain significance Single submitter
- MRGPRX1 p.Arg293Trp Uncertain significance Single submitter
- MRGPRX1 p.Arg55Pro Uncertain significance Single submitter
- MRGPRX1 p.Asn264Lys Uncertain significance Single submitter
- MRGPRX1 p.Asn67Asp Uncertain significance Single submitter
- MRGPRX1 p.Asn67Lys Uncertain significance Single submitter
- MRGPRX1 p.Cys161Arg Uncertain significance Single submitter
- MRGPRX1 p.Cys204Tyr Uncertain significance Single submitter
- MRGPRX1 p.Glu310Asp Uncertain significance Single submitter
- MRGPRX1 p.Gly109Ser Uncertain significance Single submitter
- MRGPRX1 p.Gly193Val Likely benign Single submitter
- MRGPRX1 p.Gly229Asp Uncertain significance Single submitter
- MRGPRX1 p.Gly41Arg Uncertain significance Single submitter
- MRGPRX1 p.Gly78Arg Uncertain significance Single submitter
- MRGPRX1 p.Ile179Thr Uncertain significance Single submitter
- MRGPRX1 p.Leu22Pro Likely benign Single submitter
- MRGPRX1 p.Leu238Pro Uncertain significance Single submitter
- MRGPRX1 p.Leu308Phe Uncertain significance Single submitter
- MRGPRX1 p.Leu74Phe Uncertain significance Single submitter
- MRGPRX1 p.Phe61Val Uncertain significance Single submitter
- MRGPRX1 p.Phe75Cys Likely benign Single submitter
- MRGPRX1 p.Pro127Leu Uncertain significance Single submitter
- MRGPRX1 p.Pro127Ser Uncertain significance Single submitter
- MRGPRX1 p.Pro135Leu Uncertain significance Single submitter
- MRGPRX1 p.Ser261Tyr Uncertain significance Single submitter
- MRGPRX1 p.Ser29Arg Uncertain significance Single submitter
- MRGPRX1 p.Ser62Cys Uncertain significance Single submitter
- MRGPRX1 p.Ser77Arg Uncertain significance Single submitter
- MRGPRX1 p.Trp183Ser Uncertain significance Single submitter
- MRGPRX1 p.Trp50Arg Uncertain significance Single submitter
- MRGPRX1 p.Val101Glu Uncertain significance Single submitter
- MRGPRX1 p.Val101Met Uncertain significance Single submitter
- MRGPRX1 p.Val116Gly Uncertain significance Single submitter
- MRGPRX1 p.Val216Met Uncertain significance Single submitter
- MRGPRX1 p.Val32Gly Likely benign Single submitter
All MRGPRX1 variants
Benign 2
- p.Arg55Leu Multiple submitters ⚠
- p.Leu223= Multiple submitters
Likely benign 19
- p.Ala298Thr Single submitter
- p.Cys188Phe Single submitter
- p.Gln282= Single submitter
- p.Glu310Gln Single submitter
- p.Gly167Asp Single submitter
- p.Gly193= Single submitter
- p.Gly193Val Single submitter ⚠
- p.Ile200Val Single submitter
- p.Ile202= Single submitter
- p.Ile209Met Single submitter
- p.Leu160Phe Single submitter
- p.Leu22Pro Single submitter ⚠
- p.Leu230= Single submitter
- p.Leu30Phe Single submitter
- p.Leu42= Single submitter
- p.Leu8Trp Single submitter
- p.Phe75Cys Single submitter ⚠
- p.Ser299Pro Single submitter
- p.Val32Gly Single submitter ⚠
Uncertain significance 52
- p.Ala115Gly Single submitter ⚠
- p.Ala182Ser Single submitter ⚠
- p.Ala70Ser Single submitter ⚠
- p.Arg120Cys Single submitter ⚠
- p.Arg134Leu Single submitter ⚠
- p.Arg293Trp Single submitter ⚠
- p.Arg55Pro Single submitter ⚠
- p.Arg79Cys Single submitter ⚠
- p.Asn264Lys Single submitter ⚠
- p.Asn67Asp Single submitter ⚠
- p.Asn67Lys Single submitter ⚠
- p.Asp169His Single submitter ⚠
- p.Asp72Glu Single submitter ⚠
- p.Cys161Arg Single submitter ⚠
- p.Cys204Tyr Single submitter ⚠
- p.Glu310Asp Single submitter ⚠
- p.Glu321Gln Single submitter ⚠
- p.Gly109Ser Single submitter ⚠
- p.Gly162Asp Single submitter ⚠
- p.Gly229Asp Single submitter ⚠
- p.Gly317Arg Single submitter ⚠
- p.Gly41Arg Single submitter ⚠
- p.Gly78Arg Single submitter ⚠
- p.Ile179Thr Single submitter ⚠
- p.Ile185Phe Single submitter ⚠
- p.Ile65Val Single submitter ⚠
- p.Ile90Thr Single submitter ⚠
- p.Leu238Pro Single submitter ⚠
- p.Leu308Phe Single submitter ⚠
- p.Leu74Phe Single submitter ⚠
- p.Phe165Leu Single submitter ⚠
- p.Phe61Val Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Pro127Ser Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro14Ser Single submitter ⚠
- p.Pro3Ala Single submitter ⚠
- p.Ser261Tyr Single submitter ⚠
- p.Ser29Arg Single submitter ⚠
- p.Ser62Cys Single submitter ⚠
- p.Ser77Arg Single submitter ⚠
- p.Ser86Ile Single submitter ⚠
- p.Ser89Asn Single submitter ⚠
- p.Thr43Ile Single submitter ⚠
- p.Trp183Ser Single submitter ⚠
- p.Trp50Arg Single submitter ⚠
- p.Val101Glu Single submitter ⚠
- p.Val101Met Single submitter ⚠
- p.Val116Gly Single submitter ⚠
- p.Val181Ile Single submitter ⚠
- p.Val216Met Single submitter ⚠
- p.Val244Met Single submitter ⚠