MRGPRX2 — 43 ClinVar variants
All ClinVar germline MRGPRX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
4 Likely benign · 39 Uncertain significance
Full MRGPRX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRGPRX2 p.Ala21Ser Uncertain significance Single submitter
- MRGPRX2 p.Asn48Asp Uncertain significance Single submitter
- MRGPRX2 p.Asp174Gly Uncertain significance Single submitter
- MRGPRX2 p.Gly315Arg Uncertain significance Single submitter
- MRGPRX2 p.Ile278Asn Uncertain significance Single submitter
- MRGPRX2 p.Lys251Arg Uncertain significance Single submitter
- MRGPRX2 p.Met119Val Uncertain significance Single submitter
- MRGPRX2 p.Phe170Tyr Uncertain significance Single submitter
- MRGPRX2 p.Ser124Arg Uncertain significance Single submitter
- MRGPRX2 p.Thr125Ala Uncertain significance Single submitter
- MRGPRX2 p.Val131Ile Uncertain significance Single submitter
- MRGPRX2 p.Val15Ala Uncertain significance Single submitter
- MRGPRX2 p.Val207Ala Uncertain significance Single submitter
- MRGPRX2 p.Val34Asp Uncertain significance Single submitter
- MRGPRX2 p.Val46Leu Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- MRGPRX2 p.Arg143Thr Uncertain significance Single submitter
- MRGPRX2 p.Arg208Thr Uncertain significance Single submitter
- MRGPRX2 p.Arg58Cys Uncertain significance Single submitter
- MRGPRX2 p.Arg58Leu Uncertain significance Single submitter
- MRGPRX2 p.Arg60Cys Uncertain significance Single submitter
- MRGPRX2 p.Arg60His Uncertain significance Single submitter
- MRGPRX2 p.Cys258Phe Uncertain significance Single submitter
- MRGPRX2 p.Cys80Tyr Uncertain significance Single submitter
- MRGPRX2 p.Gln242Lys Uncertain significance Single submitter
- MRGPRX2 p.Gly175Asp Uncertain significance Single submitter
- MRGPRX2 p.Gly49Arg Uncertain significance Single submitter
- MRGPRX2 p.His144Tyr Uncertain significance Single submitter
- MRGPRX2 p.Ile192Thr Uncertain significance Single submitter
- MRGPRX2 p.Ile278Val Uncertain significance Single submitter
- MRGPRX2 p.Leu296Phe Uncertain significance Single submitter
- MRGPRX2 p.Leu55Pro Uncertain significance Single submitter
- MRGPRX2 p.Leu69Val Uncertain significance Single submitter
- MRGPRX2 p.Pro33Arg Uncertain significance Single submitter
- MRGPRX2 p.Pro33Leu Likely benign Single submitter
- MRGPRX2 p.Ser12Arg Uncertain significance Single submitter
- MRGPRX2 p.Ser213Pro Uncertain significance Single submitter
- MRGPRX2 p.Ser91Gly Uncertain significance Single submitter
- MRGPRX2 p.Thr122Ile Uncertain significance Single submitter
- MRGPRX2 p.Val123Gly Uncertain significance Single submitter
- MRGPRX2 p.Val131Leu Uncertain significance Single submitter
- MRGPRX2 p.Val46Ala Likely benign Single submitter
All MRGPRX2 variants
Likely benign 4
- p.Phe317Leu Single submitter
- p.Pro33Leu Single submitter ⚠
- p.Val46Ala Single submitter ⚠
- p.Val68Ile Single submitter
Uncertain significance 39
- p.Ala21Ser Single submitter ⚠
- p.Arg143Thr Single submitter ⚠
- p.Arg208Thr Single submitter ⚠
- p.Arg58Cys Single submitter ⚠
- p.Arg58Leu Single submitter ⚠
- p.Arg60Cys Single submitter ⚠
- p.Arg60His Single submitter ⚠
- p.Asn48Asp Single submitter ⚠
- p.Asp174Gly Single submitter ⚠
- p.Cys258Phe Single submitter ⚠
- p.Cys80Tyr Single submitter ⚠
- p.Gln242Lys Single submitter ⚠
- p.Gly175Asp Single submitter ⚠
- p.Gly315Arg Single submitter ⚠
- p.Gly49Arg Single submitter ⚠
- p.His144Tyr Single submitter ⚠
- p.Ile192Thr Single submitter ⚠
- p.Ile278Asn Single submitter ⚠
- p.Ile278Val Single submitter ⚠
- p.Leu296Phe Single submitter ⚠
- p.Leu55Pro Single submitter ⚠
- p.Leu69Val Single submitter ⚠
- p.Lys251Arg Single submitter ⚠
- p.Met119Val Single submitter ⚠
- p.Phe170Tyr Single submitter ⚠
- p.Pro33Arg Single submitter ⚠
- p.Ser124Arg Single submitter ⚠
- p.Ser12Arg Single submitter ⚠
- p.Ser213Pro Single submitter ⚠
- p.Ser91Gly Single submitter ⚠
- p.Thr122Ile Single submitter ⚠
- p.Thr125Ala Single submitter ⚠
- p.Val123Gly Single submitter ⚠
- p.Val131Ile Single submitter ⚠
- p.Val131Leu Single submitter ⚠
- p.Val15Ala Single submitter ⚠
- p.Val207Ala Single submitter ⚠
- p.Val34Asp Single submitter ⚠
- p.Val46Leu Single submitter ⚠