MRGPRX4 — 56 ClinVar variants
All ClinVar germline MRGPRX4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
4 Benign · 6 Likely benign · 46 Uncertain significance
Full MRGPRX4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRGPRX4 p.Ala237Ser Uncertain significance Single submitter
- MRGPRX4 p.Ala69Val Uncertain significance Single submitter
- MRGPRX4 p.Arg18His Uncertain significance Single submitter
- MRGPRX4 p.Arg281His Uncertain significance Single submitter
- MRGPRX4 p.Arg57His Uncertain significance Single submitter
- MRGPRX4 p.Arg95His Uncertain significance Single submitter
- MRGPRX4 p.Arg95Leu Uncertain significance Single submitter
- MRGPRX4 p.Asn89Ser Uncertain significance Single submitter
- MRGPRX4 p.Glu19Lys Uncertain significance Single submitter
- MRGPRX4 p.Glu20Gly Uncertain significance Single submitter
- MRGPRX4 p.Glu314Gln Uncertain significance Single submitter
- MRGPRX4 p.Gly229Ser Uncertain significance Single submitter
- MRGPRX4 p.His137Tyr Uncertain significance Single submitter
- MRGPRX4 p.Ile37Val Uncertain significance Single submitter
- MRGPRX4 p.Ile80Leu Uncertain significance Single submitter
- MRGPRX4 p.Leu145Met Uncertain significance Single submitter
- MRGPRX4 p.Leu227Pro Uncertain significance Single submitter
- MRGPRX4 p.Leu85Ile Uncertain significance Single submitter
- MRGPRX4 p.Met242Thr Uncertain significance Single submitter
- MRGPRX4 p.Met258Thr Uncertain significance Single submitter
- MRGPRX4 p.Pro22Ser Uncertain significance Single submitter
- MRGPRX4 p.Pro299Arg Uncertain significance Single submitter
- MRGPRX4 p.Pro3Ser Uncertain significance Single submitter
- MRGPRX4 p.Pro6Arg Uncertain significance Single submitter
- MRGPRX4 p.Ser100Phe Uncertain significance Single submitter
- MRGPRX4 p.Ser176Leu Uncertain significance Single submitter
- MRGPRX4 p.Thr4Ser Uncertain significance Single submitter
- MRGPRX4 p.Trp50Cys Uncertain significance Single submitter
- MRGPRX4 p.Tyr54His Uncertain significance Single submitter
- MRGPRX4 p.Val224Ile Uncertain significance Single submitter
- MRGPRX4 p.Val256Leu Uncertain significance Single submitter
- MRGPRX4 p.Val40Ile Uncertain significance Single submitter
- MRGPRX4 p.Val99Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- MRGPRX4 p.Ser150Phe Benign Multiple submitters
- MRGPRX4 p.Ala115Asp Uncertain significance Single submitter
- MRGPRX4 p.Arg134His Uncertain significance Single submitter
- MRGPRX4 p.Cys121Gly Uncertain significance Single submitter
- MRGPRX4 p.Gly148Asp Uncertain significance Single submitter
- MRGPRX4 p.Gly276Cys Uncertain significance Single submitter
- MRGPRX4 p.Gly41Ala Uncertain significance Single submitter
- MRGPRX4 p.Leu291Pro Uncertain significance Single submitter
- MRGPRX4 p.Leu66Arg Uncertain significance Single submitter
- MRGPRX4 p.Phe73Ser Uncertain significance Single submitter
- MRGPRX4 p.Ser62Cys Uncertain significance Single submitter
- MRGPRX4 p.Val193Asp Uncertain significance Single submitter
- MRGPRX4 p.Val32Gly Uncertain significance Single submitter
All MRGPRX4 variants
Benign 4
- p.Pro269Leu Multiple submitters
- p.Ser150Phe Multiple submitters ⚠
- p.Val142Met Multiple submitters
- p.Val124Ile Single submitter
Likely benign 6
- p.Arg159Met Single submitter
- p.Glu305Gly Single submitter
- p.Gly148Ala Single submitter
- p.Lys303Glu Single submitter
- p.Thr136Arg Single submitter
- p.Val5Ile Single submitter
Uncertain significance 46
- p.Ala115Asp Single submitter ⚠
- p.Ala237Ser Single submitter ⚠
- p.Ala69Val Single submitter ⚠
- p.Arg134His Single submitter ⚠
- p.Arg18His Single submitter ⚠
- p.Arg281His Single submitter ⚠
- p.Arg57His Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Arg95Leu Single submitter ⚠
- p.Asn89Ser Single submitter ⚠
- p.Cys121Gly Single submitter ⚠
- p.Glu119Lys Single submitter
- p.Glu19Lys Single submitter ⚠
- p.Glu20Gly Single submitter ⚠
- p.Glu314Gln Single submitter ⚠
- p.Gly148Asp Single submitter ⚠
- p.Gly229Ser Single submitter ⚠
- p.Gly276Cys Single submitter ⚠
- p.Gly41Ala Single submitter ⚠
- p.His137Tyr Single submitter ⚠
- p.Ile37Val Single submitter ⚠
- p.Ile80Leu Single submitter ⚠
- p.Leu145Met Single submitter ⚠
- p.Leu227Pro Single submitter ⚠
- p.Leu291Pro Single submitter ⚠
- p.Leu66Arg Single submitter ⚠
- p.Leu85Ile Single submitter ⚠
- p.Met242Thr Single submitter ⚠
- p.Met258Thr Single submitter ⚠
- p.Phe73Ser Single submitter ⚠
- p.Pro22Ser Single submitter ⚠
- p.Pro299Arg Single submitter ⚠
- p.Pro3Ser Single submitter ⚠
- p.Pro6Arg Single submitter ⚠
- p.Ser100Phe Single submitter ⚠
- p.Ser176Leu Single submitter ⚠
- p.Ser62Cys Single submitter ⚠
- p.Thr4Ser Single submitter ⚠
- p.Trp50Cys Single submitter ⚠
- p.Tyr54His Single submitter ⚠
- p.Val193Asp Single submitter ⚠
- p.Val224Ile Single submitter ⚠
- p.Val256Leu Single submitter ⚠
- p.Val32Gly Single submitter ⚠
- p.Val40Ile Single submitter ⚠
- p.Val99Ile Single submitter ⚠