MRM1 — 57 ClinVar variants
All ClinVar germline MRM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
2 Benign · 1 Likely benign · 54 Uncertain significance
Full MRM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRM1 p.Ala134Ser Uncertain significance Single submitter
- MRM1 p.Ala215Thr Uncertain significance Single submitter
- MRM1 p.Ala328Thr Uncertain significance Single submitter
- MRM1 p.Ala65Ser Uncertain significance Single submitter
- MRM1 p.Ala76Gly Uncertain significance Single submitter
- MRM1 p.Arg112His Uncertain significance Single submitter
- MRM1 p.Arg280Gln Uncertain significance Single submitter
- MRM1 p.Arg281His Uncertain significance Single submitter
- MRM1 p.Arg316Lys Uncertain significance Single submitter
- MRM1 p.Arg85Trp Uncertain significance Single submitter
- MRM1 p.Arg8Trp Uncertain significance Single submitter
- MRM1 p.Asn351Ser Uncertain significance Single submitter
- MRM1 p.Asp172His Uncertain significance Single submitter
- MRM1 p.Cys58Trp Uncertain significance Single submitter
- MRM1 p.Gln212Arg Uncertain significance Single submitter
- MRM1 p.Glu133Gly Uncertain significance Single submitter
- MRM1 p.Gly118Ser Uncertain significance Single submitter
- MRM1 p.Gly135Glu Uncertain significance Single submitter
- MRM1 p.Gly209Arg Uncertain significance Single submitter
- MRM1 p.Gly226Ser Uncertain significance Single submitter
- MRM1 p.Gly314Ala Uncertain significance Single submitter
- MRM1 p.Gly314Trp Uncertain significance Single submitter
- MRM1 p.Gly340Arg Uncertain significance Single submitter
- MRM1 p.Gly80Arg Uncertain significance Single submitter
- MRM1 p.Gly80Glu Uncertain significance Single submitter
- MRM1 p.His22Leu Uncertain significance Single submitter
- MRM1 p.His338Gln Uncertain significance Single submitter
- MRM1 p.Leu4Pro Uncertain significance Single submitter
- MRM1 p.Leu81Val Uncertain significance Single submitter
- MRM1 p.Lys308Arg Uncertain significance Single submitter
- MRM1 p.Lys347Arg Uncertain significance Single submitter
- MRM1 p.Met335Arg Uncertain significance Single submitter
- MRM1 p.Met91Val Uncertain significance Single submitter
- MRM1 p.Phe310Ser Uncertain significance Single submitter
- MRM1 p.Pro323Thr Uncertain significance Single submitter
- MRM1 p.Ser229Asn Uncertain significance Single submitter
- MRM1 p.Ser302Thr Uncertain significance Single submitter
- MRM1 p.Thr312Ile Uncertain significance Single submitter
- MRM1 p.Thr6Ile Uncertain significance Single submitter
- MRM1 p.Trp219Cys Uncertain significance Single submitter
- MRM1 p.Val221Leu Uncertain significance Single submitter
- MRM1 p.Val255Glu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- MRM1 p.Ala222Ser Uncertain significance Single submitter
- MRM1 p.Arg281Cys Uncertain significance Single submitter
- MRM1 p.Arg66Ser Uncertain significance Single submitter
- MRM1 p.Arg67Pro Uncertain significance Single submitter
- MRM1 p.Gln145His Uncertain significance Single submitter
- MRM1 p.Glu266Lys Uncertain significance Single submitter
- MRM1 p.Phe168Leu Benign Single submitter
- MRM1 p.Ser305Asn Uncertain significance Single submitter
- MRM1 p.Thr224Met Uncertain significance Single submitter
- MRM1 p.Val115Phe Uncertain significance Single submitter
- MRM1 p.Val221Met Uncertain significance Single submitter
All MRM1 variants
Benign 2
- p.Cys120Ser Multiple submitters
- p.Phe168Leu Single submitter ⚠
Likely benign 1
- p.Glu237Lys Single submitter
Uncertain significance 54
- p.Ala134Ser Single submitter ⚠
- p.Ala215Thr Single submitter ⚠
- p.Ala222Ser Single submitter ⚠
- p.Ala328Thr Single submitter ⚠
- p.Ala65Ser Single submitter ⚠
- p.Ala76Gly Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg280Gln Single submitter ⚠
- p.Arg281Cys Single submitter ⚠
- p.Arg281His Single submitter ⚠
- p.Arg316Lys Single submitter ⚠
- p.Arg66Ser Single submitter ⚠
- p.Arg67Pro Single submitter ⚠
- p.Arg85Trp Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Asn351Ser Single submitter ⚠
- p.Asp172His Single submitter ⚠
- p.Cys58Trp Single submitter ⚠
- p.Gln145His Single submitter ⚠
- p.Gln212Arg Single submitter ⚠
- p.Glu133Gly Single submitter ⚠
- p.Glu266Lys Single submitter ⚠
- p.Gly118Ser Single submitter ⚠
- p.Gly135Glu Single submitter ⚠
- p.Gly209Arg Single submitter ⚠
- p.Gly223Ser Single submitter
- p.Gly226Ser Single submitter ⚠
- p.Gly314Ala Single submitter ⚠
- p.Gly314Trp Single submitter ⚠
- p.Gly340Arg Single submitter ⚠
- p.Gly80Arg Single submitter ⚠
- p.Gly80Glu Single submitter ⚠
- p.His22Leu Single submitter ⚠
- p.His338Gln Single submitter ⚠
- p.Leu4Pro Single submitter ⚠
- p.Leu81Val Single submitter ⚠
- p.Lys308Arg Single submitter ⚠
- p.Lys347Arg Single submitter ⚠
- p.Met335Arg Single submitter ⚠
- p.Met91Val Single submitter ⚠
- p.Phe310Ser Single submitter ⚠
- p.Pro186Leu Single submitter
- p.Pro323Thr Single submitter ⚠
- p.Ser229Asn Single submitter ⚠
- p.Ser302Thr Single submitter ⚠
- p.Ser305Asn Single submitter ⚠
- p.Thr224Met Single submitter ⚠
- p.Thr312Ile Single submitter ⚠
- p.Thr6Ile Single submitter ⚠
- p.Trp219Cys Single submitter ⚠
- p.Val115Phe Single submitter ⚠
- p.Val221Leu Single submitter ⚠
- p.Val221Met Single submitter ⚠
- p.Val255Glu Single submitter ⚠