Sugi Variant

Sugi Variant/MRNIP

MRNIP — 13 ClinVar variants

All ClinVar germline MRNIP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 3 flagged for review →

2 Conflicting · 1 Benign/Likely benign · 4 Likely benign · 6 Uncertain significance

Full MRNIP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 3

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 2

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 1

The independent predictors disagree with each other — read with care.

All MRNIP variants

Conflicting classifications of pathogenicity 2

  • p.Ala281= Single submitter Paget disease of bone 3
  • p.Asp331= Single submitter Paget disease of bone 3

Benign/Likely benign 1

  • p.Asp243= Multiple submitters Paget disease of bone 3

Likely benign 4

Uncertain significance 6