MRPL21 — 31 ClinVar variants
All ClinVar germline MRPL21 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Likely benign · 30 Uncertain significance
Full MRPL21 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPL21 p.Ala123Val Uncertain significance Single submitter
- MRPL21 p.Ala201Ser Uncertain significance Single submitter
- MRPL21 p.Arg194Gln Uncertain significance Single submitter
- MRPL21 p.Arg38Gly Uncertain significance Single submitter
- MRPL21 p.Cys17Ser Uncertain significance Single submitter
- MRPL21 p.Gln42Arg Uncertain significance Single submitter
- MRPL21 p.Glu72Asp Uncertain significance Single submitter
- MRPL21 p.Gly28Ala Uncertain significance Single submitter
- MRPL21 p.Ile195Arg Uncertain significance Single submitter
- MRPL21 p.Leu122Phe Uncertain significance Single submitter
- MRPL21 p.Pro27Ser Uncertain significance Single submitter
- MRPL21 p.Pro60Ser Uncertain significance Single submitter
- MRPL21 p.Pro69Ala Uncertain significance Single submitter
- MRPL21 p.Ser34Phe Uncertain significance Single submitter
- MRPL21 p.Ser41Thr Uncertain significance Single submitter
- MRPL21 p.Tyr46Cys Uncertain significance Single submitter
- MRPL21 p.Tyr50Cys Uncertain significance Single submitter
- MRPL21 p.Tyr92Cys Uncertain significance Single submitter
- MRPL21 p.Val88Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- MRPL21 p.Arg104Cys Uncertain significance Single submitter
- MRPL21 p.Arg129Gln Uncertain significance Single submitter
- MRPL21 p.Glu157Lys Uncertain significance Single submitter
- MRPL21 p.His100Arg Uncertain significance Single submitter
- MRPL21 p.His75Asp Uncertain significance Single submitter
- MRPL21 p.Ile87Phe Uncertain significance Single submitter
- MRPL21 p.Lys82Met Uncertain significance Single submitter
- MRPL21 p.Phe180Leu Uncertain significance Single submitter
All MRPL21 variants
Likely benign 1
- p.Arg173Lys Single submitter
Uncertain significance 30
- p.Ala123Val Single submitter ⚠
- p.Ala201Ser Single submitter ⚠
- p.Arg104Cys Single submitter ⚠
- p.Arg129Gln Single submitter ⚠
- p.Arg194Gln Single submitter ⚠
- p.Arg38Gly Single submitter ⚠
- p.Cys17Ser Single submitter ⚠
- p.Gln42Arg Single submitter ⚠
- p.Glu157Lys Single submitter ⚠
- p.Glu72Asp Single submitter ⚠
- p.Gly28Ala Single submitter ⚠
- p.Gly90Trp Single submitter
- p.His100Arg Single submitter ⚠
- p.His75Asp Single submitter ⚠
- p.Ile195Arg Single submitter ⚠
- p.Ile87Phe Single submitter ⚠
- p.Leu122Phe Single submitter ⚠
- p.Lys132Arg Single submitter
- p.Lys82Met Single submitter ⚠
- p.Phe180Leu Single submitter ⚠
- p.Pro27Ser Single submitter ⚠
- p.Pro59Ser Single submitter
- p.Pro60Ser Single submitter ⚠
- p.Pro69Ala Single submitter ⚠
- p.Ser34Phe Single submitter ⚠
- p.Ser41Thr Single submitter ⚠
- p.Tyr46Cys Single submitter ⚠
- p.Tyr50Cys Single submitter ⚠
- p.Tyr92Cys Single submitter ⚠
- p.Val88Ile Single submitter ⚠