MRPS18A — 45 ClinVar variants
All ClinVar germline MRPS18A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
3 Likely benign · 42 Uncertain significance
Full MRPS18A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPS18A p.Arg113His Uncertain significance Single submitter
- MRPS18A p.Arg124Gln Uncertain significance Single submitter
- MRPS18A p.Arg134Gln Uncertain significance Single submitter
- MRPS18A p.Arg153His Uncertain significance Single submitter
- MRPS18A p.Arg173Gly Uncertain significance Single submitter
- MRPS18A p.Arg173His Uncertain significance Single submitter
- MRPS18A p.Arg173Leu Uncertain significance Single submitter
- MRPS18A p.Arg52Cys Uncertain significance Single submitter
- MRPS18A p.Arg52His Uncertain significance Single submitter
- MRPS18A p.Arg74Cys Uncertain significance Single submitter
- MRPS18A p.Asn76Tyr Uncertain significance Single submitter
- MRPS18A p.Gln69Arg Uncertain significance Single submitter
- MRPS18A p.Gly21Asp Uncertain significance Single submitter
- MRPS18A p.Gly21Val Uncertain significance Single submitter
- MRPS18A p.Gly34Ala Uncertain significance Single submitter
- MRPS18A p.Ile115Met Uncertain significance Single submitter
- MRPS18A p.Ile93Met Uncertain significance Single submitter
- MRPS18A p.Leu15Val Uncertain significance Single submitter
- MRPS18A p.Lys5Gln Uncertain significance Single submitter
- MRPS18A p.Pro141Leu Uncertain significance Single submitter
- MRPS18A p.Pro156Ser Uncertain significance Single submitter
- MRPS18A p.Pro161Ala Uncertain significance Single submitter
- MRPS18A p.Pro31Leu Uncertain significance Single submitter
- MRPS18A p.Pro31Thr Uncertain significance Single submitter
- MRPS18A p.Ser178Leu Uncertain significance Single submitter
- MRPS18A p.Ser188Pro Uncertain significance Single submitter
- MRPS18A p.Ser9Ala Uncertain significance Single submitter
- MRPS18A p.Ser9Phe Uncertain significance Single submitter
- MRPS18A p.Thr46Ala Uncertain significance Single submitter
- MRPS18A p.Val159Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- MRPS18A p.Arg153Leu Uncertain significance Single submitter
- MRPS18A p.Arg168Gly Uncertain significance Single submitter
- MRPS18A p.Arg74His Uncertain significance Single submitter
- MRPS18A p.Arg94Trp Uncertain significance Single submitter
- MRPS18A p.Leu181Pro Uncertain significance Single submitter
- MRPS18A p.Pro161Leu Uncertain significance Single submitter
- MRPS18A p.Pro66Thr Uncertain significance Single submitter
- MRPS18A p.Trp169Arg Uncertain significance Single submitter
- MRPS18A p.Tyr83Cys Uncertain significance Single submitter
- MRPS18A p.Val176Met Uncertain significance Single submitter
All MRPS18A variants
Likely benign 3
- p.Arg182Lys Single submitter
- p.Ile104Val Single submitter
- p.Thr41Ile Single submitter
Uncertain significance 42
- p.Arg113His Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg153His Single submitter ⚠
- p.Arg153Leu Single submitter ⚠
- p.Arg168Gly Single submitter ⚠
- p.Arg173Gly Single submitter ⚠
- p.Arg173His Single submitter ⚠
- p.Arg173Leu Single submitter ⚠
- p.Arg52Cys Single submitter ⚠
- p.Arg52His Single submitter ⚠
- p.Arg74Cys Single submitter ⚠
- p.Arg74His Single submitter ⚠
- p.Arg94Trp Single submitter ⚠
- p.Asn76Tyr Single submitter ⚠
- p.Gln69Arg Single submitter ⚠
- p.Gly21Asp Single submitter ⚠
- p.Gly21Val Single submitter ⚠
- p.Gly34Ala Single submitter ⚠
- p.Ile104Asn Single submitter
- p.Ile115Met Single submitter ⚠
- p.Ile93Met Single submitter ⚠
- p.Leu15Val Single submitter ⚠
- p.Leu181Pro Single submitter ⚠
- p.Lys5Gln Single submitter ⚠
- p.Met174Val Single submitter
- p.Pro141Leu Single submitter ⚠
- p.Pro156Ser Single submitter ⚠
- p.Pro161Ala Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro31Leu Single submitter ⚠
- p.Pro31Thr Single submitter ⚠
- p.Pro66Thr Single submitter ⚠
- p.Ser178Leu Single submitter ⚠
- p.Ser188Pro Single submitter ⚠
- p.Ser9Ala Single submitter ⚠
- p.Ser9Phe Single submitter ⚠
- p.Thr46Ala Single submitter ⚠
- p.Trp169Arg Single submitter ⚠
- p.Tyr83Cys Single submitter ⚠
- p.Val159Ile Single submitter ⚠
- p.Val176Met Single submitter ⚠