MRPS18B — 47 ClinVar variants
All ClinVar germline MRPS18B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
7 Likely benign · 40 Uncertain significance
Full MRPS18B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPS18B p.Ala190Pro Uncertain significance Single submitter
- MRPS18B p.Arg11Lys Uncertain significance Single submitter
- MRPS18B p.Arg149Gln Uncertain significance Single submitter
- MRPS18B p.Arg158Lys Uncertain significance Single submitter
- MRPS18B p.Arg173Gln Uncertain significance Single submitter
- MRPS18B p.Arg173Pro Uncertain significance Single submitter
- MRPS18B p.Arg173Trp Uncertain significance Single submitter
- MRPS18B p.Arg215His Uncertain significance Single submitter
- MRPS18B p.Arg218Gln Uncertain significance Single submitter
- MRPS18B p.Arg71His Uncertain significance Single submitter
- MRPS18B p.Arg89Gln Uncertain significance Single submitter
- MRPS18B p.Arg89Trp Uncertain significance Single submitter
- MRPS18B p.Arg96His Uncertain significance Single submitter
- MRPS18B p.Asn103Ser Uncertain significance Single submitter
- MRPS18B p.Gln65Arg Uncertain significance Single submitter
- MRPS18B p.Glu245Ala Uncertain significance Single submitter
- MRPS18B p.Gly229Ser Uncertain significance Single submitter
- MRPS18B p.Ile107Val Uncertain significance Single submitter
- MRPS18B p.Ile134Met Uncertain significance Single submitter
- MRPS18B p.Leu193Arg Uncertain significance Single submitter
- MRPS18B p.Met238Thr Uncertain significance Single submitter
- MRPS18B p.Pro208Ser Uncertain significance Single submitter
- MRPS18B p.Ser22Phe Uncertain significance Single submitter
- MRPS18B p.Ser38Phe Uncertain significance Single submitter
- MRPS18B p.Thr8Asn Uncertain significance Single submitter
- MRPS18B p.Tyr136Cys Uncertain significance Single submitter
- MRPS18B p.Tyr51Phe Uncertain significance Single submitter
- MRPS18B p.Tyr64His Uncertain significance Single submitter
- MRPS18B p.Val101Ile Uncertain significance Single submitter
- MRPS18B p.Val25Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- MRPS18B p.Arg96Cys Uncertain significance Single submitter
- MRPS18B p.Asp110Glu Uncertain significance Single submitter
- MRPS18B p.Gly83Asp Uncertain significance Single submitter
- MRPS18B p.Leu219Pro Uncertain significance Single submitter
- MRPS18B p.Pro55Ser Uncertain significance Single submitter
- MRPS18B p.Thr90Ile Uncertain significance Single submitter
All MRPS18B variants
Likely benign 7
- p.Gln251His Single submitter
- p.Leu16= Single submitter
- p.Lys148Arg Single submitter
- p.Met15Val Single submitter
- p.Pro14Ser Single submitter
- p.Pro28Leu Single submitter
- p.Val73Ile Single submitter
Uncertain significance 40
- p.Ala190Pro Single submitter ⚠
- p.Arg11Lys Single submitter ⚠
- p.Arg149Gln Single submitter ⚠
- p.Arg158Lys Single submitter ⚠
- p.Arg173Gln Single submitter ⚠
- p.Arg173Pro Single submitter ⚠
- p.Arg173Trp Single submitter ⚠
- p.Arg215His Single submitter ⚠
- p.Arg218Gln Single submitter ⚠
- p.Arg71His Single submitter ⚠
- p.Arg89Gln Single submitter ⚠
- p.Arg89Trp Single submitter ⚠
- p.Arg91Gln Single submitter
- p.Arg96Cys Single submitter ⚠
- p.Arg96His Single submitter ⚠
- p.Asn103Ser Single submitter ⚠
- p.Asp110Glu Single submitter ⚠
- p.Asp116Asn Single submitter
- p.Gln65Arg Single submitter ⚠
- p.Glu245Ala Single submitter ⚠
- p.Gly229Ser Single submitter ⚠
- p.Gly69Cys Single submitter
- p.Gly83Asp Single submitter ⚠
- p.Ile107Val Single submitter ⚠
- p.Ile134Met Single submitter ⚠
- p.Leu193Arg Single submitter ⚠
- p.Leu219Pro Single submitter ⚠
- p.Met238Thr Single submitter ⚠
- p.Pro208Ser Single submitter ⚠
- p.Pro55Ser Single submitter ⚠
- p.Ser22Phe Single submitter ⚠
- p.Ser38Phe Single submitter ⚠
- p.Thr131Met Single submitter
- p.Thr8Asn Single submitter ⚠
- p.Thr90Ile Single submitter ⚠
- p.Tyr136Cys Single submitter ⚠
- p.Tyr51Phe Single submitter ⚠
- p.Tyr64His Single submitter ⚠
- p.Val101Ile Single submitter ⚠
- p.Val25Leu Single submitter ⚠