MRPS27 — 65 ClinVar variants
All ClinVar germline MRPS27 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
3 Benign · 4 Likely benign · 58 Uncertain significance
Full MRPS27 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPS27 p.Ala172Asp Uncertain significance Single submitter
- MRPS27 p.Ala279Thr Uncertain significance Single submitter
- MRPS27 p.Ala289Thr Uncertain significance Single submitter
- MRPS27 p.Ala336Thr Uncertain significance Single submitter
- MRPS27 p.Arg241Gln Uncertain significance Single submitter
- MRPS27 p.Arg241Trp Uncertain significance Single submitter
- MRPS27 p.Arg277Gly Uncertain significance Single submitter
- MRPS27 p.Arg333Gln Uncertain significance Single submitter
- MRPS27 p.Arg63Lys Uncertain significance Single submitter
- MRPS27 p.Arg74Gln Uncertain significance Single submitter
- MRPS27 p.Arg7Trp Uncertain significance Single submitter
- MRPS27 p.Arg96Gln Uncertain significance Single submitter
- MRPS27 p.Asn100Ser Uncertain significance Single submitter
- MRPS27 p.Asp159Gly Uncertain significance Single submitter
- MRPS27 p.Asp281Asn Uncertain significance Single submitter
- MRPS27 p.Asp304Tyr Uncertain significance Single submitter
- MRPS27 p.Cys367Tyr Uncertain significance Single submitter
- MRPS27 p.Gln115Arg Uncertain significance Single submitter
- MRPS27 p.Gln20His Uncertain significance Single submitter
- MRPS27 p.Gln377Arg Uncertain significance Single submitter
- MRPS27 p.Gln377Glu Uncertain significance Single submitter
- MRPS27 p.Gln380Arg Uncertain significance Single submitter
- MRPS27 p.Glu298Gly Uncertain significance Single submitter
- MRPS27 p.Glu305Lys Uncertain significance Single submitter
- MRPS27 p.Glu320Lys Uncertain significance Single submitter
- MRPS27 p.Glu348Lys Uncertain significance Single submitter
- MRPS27 p.Glu89Gln Uncertain significance Single submitter
- MRPS27 p.Gly309Val Uncertain significance Single submitter
- MRPS27 p.Ile109Met Uncertain significance Single submitter
- MRPS27 p.Ile372Met Uncertain significance Single submitter
- MRPS27 p.Ile85Val Uncertain significance Single submitter
- MRPS27 p.Leu129Val Uncertain significance Single submitter
- MRPS27 p.Leu18Pro Uncertain significance Single submitter
- MRPS27 p.Leu18Val Uncertain significance Single submitter
- MRPS27 p.Leu290Val Uncertain significance Single submitter
- MRPS27 p.Leu53His Uncertain significance Single submitter
- MRPS27 p.Lys154Glu Uncertain significance Single submitter
- MRPS27 p.Lys59Glu Uncertain significance Single submitter
- MRPS27 p.Met263Val Uncertain significance Single submitter
- MRPS27 p.Phe334Ser Uncertain significance Single submitter
- MRPS27 p.Pro176His Uncertain significance Single submitter
- MRPS27 p.Ser37Cys Uncertain significance Single submitter
- MRPS27 p.Thr357Ala Uncertain significance Single submitter
- MRPS27 p.Thr60Ala Uncertain significance Single submitter
- MRPS27 p.Tyr48Asn Uncertain significance Single submitter
- MRPS27 p.Val16Gly Uncertain significance Single submitter
- MRPS27 p.Val262Met Uncertain significance Single submitter
- MRPS27 p.Val35Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- MRPS27 p.Asn217Lys Uncertain significance Single submitter
- MRPS27 p.Asp281Tyr Uncertain significance Single submitter
- MRPS27 p.Asp371Ala Uncertain significance Single submitter
- MRPS27 p.Asp371Asn Uncertain significance Single submitter
- MRPS27 p.Ile79Thr Uncertain significance Single submitter
- MRPS27 p.Phe204Leu Uncertain significance Single submitter
- MRPS27 p.Pro328Leu Uncertain significance Single submitter
- MRPS27 p.Trp251Arg Uncertain significance Single submitter
All MRPS27 variants
Benign 3
- p.Leu280= Multiple submitters
- p.Thr291Ala Multiple submitters
- p.Pro253Ser Single submitter
Likely benign 4
- p.Asn307Lys Single submitter
- p.Ile5Met Single submitter
- p.Met10Ile Single submitter
- p.Tyr228Cys Single submitter
Uncertain significance 58
- p.Ala172Asp Single submitter ⚠
- p.Ala279Thr Single submitter ⚠
- p.Ala289Thr Single submitter ⚠
- p.Ala336Thr Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Arg277Gly Single submitter ⚠
- p.Arg333Gln Single submitter ⚠
- p.Arg63Lys Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Arg7Trp Single submitter ⚠
- p.Arg96Gln Single submitter ⚠
- p.Asn100Ser Single submitter ⚠
- p.Asn217Lys Single submitter ⚠
- p.Asp159Gly Single submitter ⚠
- p.Asp281Asn Single submitter ⚠
- p.Asp281Tyr Single submitter ⚠
- p.Asp304Tyr Single submitter ⚠
- p.Asp371Ala Single submitter ⚠
- p.Asp371Asn Single submitter ⚠
- p.Cys367Tyr Single submitter ⚠
- p.Gln115Arg Single submitter ⚠
- p.Gln20His Single submitter ⚠
- p.Gln377Arg Single submitter ⚠
- p.Gln377Glu Single submitter ⚠
- p.Gln380Arg Single submitter ⚠
- p.Glu298Gly Single submitter ⚠
- p.Glu305Lys Single submitter ⚠
- p.Glu320Lys Single submitter ⚠
- p.Glu348Lys Single submitter ⚠
- p.Glu89Gln Single submitter ⚠
- p.Gly205Ser Single submitter
- p.Gly309Val Single submitter ⚠
- p.Ile109Met Single submitter ⚠
- p.Ile372Met Single submitter ⚠
- p.Ile79Thr Single submitter ⚠
- p.Ile85Val Single submitter ⚠
- p.Leu129Val Single submitter ⚠
- p.Leu18Pro Single submitter ⚠
- p.Leu18Val Single submitter ⚠
- p.Leu290Val Single submitter ⚠
- p.Leu53His Single submitter ⚠
- p.Lys154Glu Single submitter ⚠
- p.Lys59Glu Single submitter ⚠
- p.Met263Val Single submitter ⚠
- p.Phe204Leu Single submitter ⚠
- p.Phe334Ser Single submitter ⚠
- p.Pro176His Single submitter ⚠
- p.Pro328Leu Single submitter ⚠
- p.Ser37Cys Single submitter ⚠
- p.Thr357Ala Single submitter ⚠
- p.Thr60Ala Single submitter ⚠
- p.Trp251Arg Single submitter ⚠
- p.Tyr48Asn Single submitter ⚠
- p.Val133Phe Single submitter
- p.Val16Gly Single submitter ⚠
- p.Val262Met Single submitter ⚠
- p.Val35Ile Single submitter ⚠