Sugi Variant

Sugi Variant/MSR1

MSR1 — 133 ClinVar variants

All ClinVar germline MSR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →

2 Pathogenic · 7 Likely pathogenic · 2 Conflicting · 14 Benign · 32 Likely benign · 76 Uncertain significance

Full MSR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 77

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 3

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 64

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 9

The independent predictors disagree with each other — read with care.

All MSR1 variants

Pathogenic 2

Likely pathogenic 7

Conflicting classifications of pathogenicity 2

Benign 14

Likely benign 32

Uncertain significance 76