MST1 — 144 ClinVar variants

All ClinVar germline MST1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more.

2 Conflicting · 2 Benign · 1 Benign/Likely benign · 13 Likely benign · 126 Uncertain significance

Full MST1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

All MST1 variants

Conflicting classifications of pathogenicity 2

p.Arg492Trp Single submitter
p.Glu658Asp Single submitter

Benign 2

p.Gly215Arg Multiple submitters
p.Arg651Ter Single submitter

Benign/Likely benign 1

p.Ser511= Multiple submitters

Likely benign 13

p.Pro326= Multiple submitters
p.Thr313= Multiple submitters
p.Ala54= Single submitter
p.Arg451Gly Single submitter
p.Asp439= Single submitter
p.Asp472Glu Single submitter
p.Cys462= Single submitter
p.Gly283= Single submitter
p.Gly389= Single submitter
p.Met448Thr Single submitter
p.Ser702= Single submitter
p.Ser702Pro Single submitter
p.Thr709Met Single submitter

Uncertain significance 126

p.Ala323Thr Single submitter
p.Ala410Thr Single submitter
p.Ala54Val Single submitter
p.Ala700Thr Single submitter
p.Arg107Trp Single submitter
p.Arg122Gly Single submitter
p.Arg122Trp Single submitter
p.Arg133Gln Single submitter
p.Arg133Trp Single submitter
p.Arg163Pro Single submitter
p.Arg172Gly Single submitter
p.Arg255Trp Single submitter
p.Arg262Gly Single submitter
p.Arg274Pro Single submitter
p.Arg306Gln Single submitter
p.Arg347Gln Single submitter
p.Arg365His Single submitter
p.Arg374Pro Single submitter
p.Arg380Gln Single submitter
p.Arg434Gln Single submitter
p.Arg434Pro Single submitter
p.Arg434Trp Single submitter
p.Arg44Gln Single submitter
p.Arg461His Single submitter
p.Arg488Gly Single submitter
p.Arg493Cys Single submitter
p.Arg497Cys Single submitter
p.Arg513Gln Single submitter
p.Arg535Gln Single submitter
p.Arg535Pro Single submitter
p.Arg535Trp Single submitter
p.Arg597His Single submitter
p.Arg651Gln Single submitter
p.Arg653His Single submitter
p.Arg653Ser Single submitter
p.Arg655Gln Single submitter
p.Arg655Trp Single submitter
p.Arg697Gln Single submitter
p.Arg703His Single submitter
p.Arg73Cys Single submitter
p.Arg73His Single submitter
p.Asn209Ser Single submitter
p.Asn435Ser Single submitter
p.Asn634His Single submitter
p.Asn696Ser Single submitter
p.Asp269Gly Single submitter
p.Asp39Gly Single submitter
p.Asp437Asn Single submitter
p.Asp487Gly Single submitter
p.Asp716Gly Single submitter
p.Cys112Tyr Single submitter
p.Cys254Arg Single submitter
p.Cys375Tyr Single submitter
p.Cys482Arg Single submitter
p.Cys646Tyr Single submitter
p.Gln232Arg Single submitter
p.Gln290Glu Single submitter
p.Gln404Glu Single submitter
p.Gln404His Single submitter
p.Gln406Glu Single submitter
p.Glu168Gly Single submitter
p.Glu303Lys Single submitter
p.Glu589Lys Single submitter
p.Glu656Gln Single submitter
p.Gly196Ser Single submitter
p.Gly387Cys Single submitter
p.Gly517Cys Single submitter
p.Gly547Cys Single submitter
p.Gly562Glu Single submitter
p.Gly58Arg Single submitter
p.Gly673Ser Single submitter
p.Gly725Ser Single submitter
p.His156Gln Single submitter
p.His386Gln Single submitter
p.His502fs Single submitter
p.His53Leu Single submitter
p.His84Tyr Single submitter
p.His90Arg Single submitter
p.Ile125Leu Single submitter
p.Ile618Met Single submitter
p.Leu43Pro Single submitter
p.Leu585Pro Single submitter
p.Lys301Asn Single submitter
p.Lys401Arg Single submitter
p.Lys527Thr Single submitter
p.Lys573Arg Single submitter
p.Met364Arg Single submitter
p.Met364Ile Single submitter
p.Met448Ile Single submitter
p.Phe152Leu Single submitter
p.Phe331Tyr Single submitter
p.Phe358Ile Single submitter
p.Pro153Leu Single submitter
p.Pro174Ser Single submitter
p.Pro178Thr Single submitter
p.Pro19Ser Single submitter
p.Pro257Leu Single submitter
p.Pro317Thr Single submitter
p.Pro31Leu Single submitter
p.Pro355Ser Single submitter
p.Pro473Ser Single submitter
p.Pro604Ser Single submitter
p.Pro605Ala Single submitter
p.Pro612Leu Single submitter
p.Ser101Leu Single submitter
p.Ser101Pro Single submitter
p.Ser35Trp Single submitter
p.Ser409Phe Single submitter
p.Ser469Pro Single submitter
p.Ser494Pro Single submitter
p.Ser657Thr Single submitter
p.Thr123Ile Single submitter
p.Thr159Ala Single submitter
p.Thr220Met Single submitter
p.Thr447Met Single submitter
p.Thr452Ile Single submitter
p.Thr631Ile Single submitter
p.Thr683Ala Single submitter
p.Trp4Ser Single submitter
p.Val130Phe Single submitter
p.Val550Ile Single submitter
p.Val610Met Single submitter
p.Val64Gly Single submitter
p.Val668Gly Single submitter
p.Val688Ile Single submitter
p.Val8Met Single submitter