MTCH2 — 33 ClinVar variants
All ClinVar germline MTCH2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
33 Uncertain significance
Full MTCH2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MTCH2 p.Ile16Leu Uncertain significance Multiple submitters
- MTCH2 p.Ala180Thr Uncertain significance Single submitter
- MTCH2 p.Arg131Cys Uncertain significance Single submitter
- MTCH2 p.Arg131His Uncertain significance Single submitter
- MTCH2 p.Arg155Lys Uncertain significance Single submitter
- MTCH2 p.Arg287Trp Uncertain significance Single submitter
- MTCH2 p.Arg46Gln Uncertain significance Single submitter
- MTCH2 p.Arg46Trp Uncertain significance Single submitter
- MTCH2 p.Asn242Ser Uncertain significance Single submitter
- MTCH2 p.Cys296Phe Uncertain significance Single submitter
- MTCH2 p.Gln273His Uncertain significance Single submitter
- MTCH2 p.Gly101Asp Uncertain significance Single submitter
- MTCH2 p.Gly253Ala Uncertain significance Single submitter
- MTCH2 p.Gly53Asp Uncertain significance Single submitter
- MTCH2 p.Gly53Cys Uncertain significance Single submitter
- MTCH2 p.Gly69Arg Uncertain significance Single submitter
- MTCH2 p.Gly89Ser Uncertain significance Single submitter
- MTCH2 p.Ile129Thr Uncertain significance Single submitter
- MTCH2 p.Ile144Val Uncertain significance Single submitter
- MTCH2 p.Ile39Thr Uncertain significance Single submitter
- MTCH2 p.Met271Val Uncertain significance Single submitter
- MTCH2 p.Phe55Ser Uncertain significance Single submitter
- MTCH2 p.Pro106Leu Uncertain significance Single submitter
- MTCH2 p.Thr125Ala Uncertain significance Single submitter
- MTCH2 p.Thr125Ile Uncertain significance Single submitter
- MTCH2 p.Thr38Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- MTCH2 p.Ala224Thr Uncertain significance Single submitter
- MTCH2 p.Arg171Trp Uncertain significance Single submitter
- MTCH2 p.Arg185His Uncertain significance Single submitter
- MTCH2 p.Cys196Tyr Uncertain significance Single submitter
- MTCH2 p.Ser264Cys Uncertain significance Single submitter
- MTCH2 p.Val48Gly Uncertain significance Single submitter
All MTCH2 variants
Uncertain significance 33
- p.Ile16Leu Multiple submitters ⚠
- p.Ala180Thr Single submitter ⚠
- p.Ala224Thr Single submitter ⚠
- p.Arg131Cys Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg155Lys Single submitter ⚠
- p.Arg171Trp Single submitter ⚠
- p.Arg185His Single submitter ⚠
- p.Arg287Trp Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Asn242Ser Single submitter ⚠
- p.Cys196Tyr Single submitter ⚠
- p.Cys296Phe Single submitter ⚠
- p.Gln273His Single submitter ⚠
- p.Gly101Asp Single submitter ⚠
- p.Gly253Ala Single submitter ⚠
- p.Gly53Asp Single submitter ⚠
- p.Gly53Cys Single submitter ⚠
- p.Gly69Arg Single submitter ⚠
- p.Gly89Ser Single submitter ⚠
- p.Ile129Thr Single submitter ⚠
- p.Ile144Val Single submitter ⚠
- p.Ile39Thr Single submitter ⚠
- p.Met271Val Single submitter ⚠
- p.Phe55Ser Single submitter ⚠
- p.Pro106Leu Single submitter ⚠
- p.Ser264Cys Single submitter ⚠
- p.Ser6Ile Single submitter
- p.Thr125Ala Single submitter ⚠
- p.Thr125Ile Single submitter ⚠
- p.Thr38Ile Single submitter ⚠
- p.Val48Gly Single submitter ⚠