Sugi Variant

Sugi Variant/MTCL1

MTCL1 — 358 ClinVar variants

All ClinVar germline MTCL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 274 flagged for review →

1 Pathogenic · 1 Conflicting · 7 Benign · 49 Likely benign · 300 Uncertain significance

Full MTCL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 274

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 238

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 238

Predictors split 35

The independent predictors disagree with each other — read with care.

All MTCL1 variants

Pathogenic 1

Conflicting classifications of pathogenicity 1

Benign 7

Likely benign 49

Uncertain significance 300