MTCL3 — 67 ClinVar variants
All ClinVar germline MTCL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
67 Uncertain significance
Full MTCL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MTCL3 p.Ala102Val Uncertain significance Single submitter
- MTCL3 p.Ala109Glu Uncertain significance Single submitter
- MTCL3 p.Ala113Val Uncertain significance Single submitter
- MTCL3 p.Ala117Ser Uncertain significance Single submitter
- MTCL3 p.Ala239Glu Uncertain significance Single submitter
- MTCL3 p.Ala270Val Uncertain significance Single submitter
- MTCL3 p.Ala304Thr Uncertain significance Single submitter
- MTCL3 p.Ala313Val Uncertain significance Single submitter
- MTCL3 p.Ala326Gly Uncertain significance Single submitter
- MTCL3 p.Ala334Thr Uncertain significance Single submitter
- MTCL3 p.Ala424Asp Uncertain significance Single submitter
- MTCL3 p.Ala880Val Uncertain significance Single submitter
- MTCL3 p.Arg891His Uncertain significance Single submitter
- MTCL3 p.Asp620Glu Uncertain significance Single submitter
- MTCL3 p.Gln277His Uncertain significance Single submitter
- MTCL3 p.Gln345Glu Uncertain significance Single submitter
- MTCL3 p.Glu372Lys Uncertain significance Single submitter
- MTCL3 p.Glu398Asp Uncertain significance Single submitter
- MTCL3 p.Glu699Gln Uncertain significance Single submitter
- MTCL3 p.Glu893Gln Uncertain significance Single submitter
- MTCL3 p.Gly210Ser Uncertain significance Single submitter
- MTCL3 p.Gly213Glu Uncertain significance Single submitter
- MTCL3 p.Gly237Arg Uncertain significance Single submitter
- MTCL3 p.Gly244Ser Uncertain significance Single submitter
- MTCL3 p.Gly247Arg Uncertain significance Single submitter
- MTCL3 p.Gly317Ser Uncertain significance Single submitter
- MTCL3 p.Gly826Ser Uncertain significance Single submitter
- MTCL3 p.Gly86Arg Uncertain significance Single submitter
- MTCL3 p.Gly902Asp Uncertain significance Single submitter
- MTCL3 p.Gly902Ser Uncertain significance Single submitter
- MTCL3 p.Gly97Arg Uncertain significance Single submitter
- MTCL3 p.His342Asp Uncertain significance Single submitter
- MTCL3 p.His555Arg Uncertain significance Single submitter
- MTCL3 p.Ile789Met Uncertain significance Single submitter
- MTCL3 p.Ile889Val Uncertain significance Single submitter
- MTCL3 p.Leu567Arg Uncertain significance Single submitter
- MTCL3 p.Lys84Gln Uncertain significance Single submitter
- MTCL3 p.Lys896Glu Uncertain significance Single submitter
- MTCL3 p.Met311Val Uncertain significance Single submitter
- MTCL3 p.Pro110Ser Uncertain significance Single submitter
- MTCL3 p.Pro216Ser Uncertain significance Single submitter
- MTCL3 p.Pro29Leu Uncertain significance Single submitter
- MTCL3 p.Pro336His Uncertain significance Single submitter
- MTCL3 p.Pro336Ser Uncertain significance Single submitter
- MTCL3 p.Pro343Leu Uncertain significance Single submitter
- MTCL3 p.Pro572Ala Uncertain significance Single submitter
- MTCL3 p.Pro633Leu Uncertain significance Single submitter
- MTCL3 p.Pro906Ser Uncertain significance Single submitter
- MTCL3 p.Pro91Leu Uncertain significance Single submitter
- MTCL3 p.Ser231Gly Uncertain significance Single submitter
- MTCL3 p.Ser327Arg Uncertain significance Single submitter
- MTCL3 p.Thr106Lys Uncertain significance Single submitter
- MTCL3 p.Thr365Ser Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- MTCL3 p.Arg58Trp Uncertain significance Single submitter
- MTCL3 p.Asn403Lys Uncertain significance Single submitter
- MTCL3 p.Gly685Cys Uncertain significance Single submitter
- MTCL3 p.Gly778Arg Uncertain significance Single submitter
- MTCL3 p.Gly7Trp Uncertain significance Single submitter
- MTCL3 p.His741Gln Uncertain significance Single submitter
- MTCL3 p.His770Arg Uncertain significance Single submitter
- MTCL3 p.Ile917Val Uncertain significance Single submitter
- MTCL3 p.Leu608Val Uncertain significance Single submitter
- MTCL3 p.Ser755Gly Uncertain significance Single submitter
- MTCL3 p.Tyr680Cys Uncertain significance Single submitter
- MTCL3 p.Tyr724Asn Uncertain significance Single submitter
- MTCL3 p.Val458Met Uncertain significance Single submitter
All MTCL3 variants
Uncertain significance 67
- p.Ala102Val Single submitter ⚠
- p.Ala109Glu Single submitter ⚠
- p.Ala113Val Single submitter ⚠
- p.Ala117Ser Single submitter ⚠
- p.Ala239Glu Single submitter ⚠
- p.Ala270Val Single submitter ⚠
- p.Ala304Thr Single submitter ⚠
- p.Ala313Val Single submitter ⚠
- p.Ala326Gly Single submitter ⚠
- p.Ala334Thr Single submitter ⚠
- p.Ala424Asp Single submitter ⚠
- p.Ala880Val Single submitter ⚠
- p.Arg58Trp Single submitter ⚠
- p.Arg891His Single submitter ⚠
- p.Asn403Lys Single submitter ⚠
- p.Asn875Ser Single submitter
- p.Asp620Glu Single submitter ⚠
- p.Gln277His Single submitter ⚠
- p.Gln345Glu Single submitter ⚠
- p.Glu372Lys Single submitter ⚠
- p.Glu398Asp Single submitter ⚠
- p.Glu699Gln Single submitter ⚠
- p.Glu893Gln Single submitter ⚠
- p.Gly210Ser Single submitter ⚠
- p.Gly213Glu Single submitter ⚠
- p.Gly237Arg Single submitter ⚠
- p.Gly244Ser Single submitter ⚠
- p.Gly247Arg Single submitter ⚠
- p.Gly317Ser Single submitter ⚠
- p.Gly685Cys Single submitter ⚠
- p.Gly778Arg Single submitter ⚠
- p.Gly7Trp Single submitter ⚠
- p.Gly826Ser Single submitter ⚠
- p.Gly86Arg Single submitter ⚠
- p.Gly902Asp Single submitter ⚠
- p.Gly902Ser Single submitter ⚠
- p.Gly97Arg Single submitter ⚠
- p.His342Asp Single submitter ⚠
- p.His555Arg Single submitter ⚠
- p.His741Gln Single submitter ⚠
- p.His770Arg Single submitter ⚠
- p.Ile789Met Single submitter ⚠
- p.Ile889Val Single submitter ⚠
- p.Ile917Val Single submitter ⚠
- p.Leu567Arg Single submitter ⚠
- p.Leu608Val Single submitter ⚠
- p.Lys84Gln Single submitter ⚠
- p.Lys896Glu Single submitter ⚠
- p.Met311Val Single submitter ⚠
- p.Pro110Ser Single submitter ⚠
- p.Pro216Ser Single submitter ⚠
- p.Pro29Leu Single submitter ⚠
- p.Pro336His Single submitter ⚠
- p.Pro336Ser Single submitter ⚠
- p.Pro343Leu Single submitter ⚠
- p.Pro572Ala Single submitter ⚠
- p.Pro633Leu Single submitter ⚠
- p.Pro906Ser Single submitter ⚠
- p.Pro91Leu Single submitter ⚠
- p.Ser231Gly Single submitter ⚠
- p.Ser327Arg Single submitter ⚠
- p.Ser755Gly Single submitter ⚠
- p.Thr106Lys Single submitter ⚠
- p.Thr365Ser Single submitter ⚠
- p.Tyr680Cys Single submitter ⚠
- p.Tyr724Asn Single submitter ⚠
- p.Val458Met Single submitter ⚠