MTNR1B — 75 ClinVar variants
All ClinVar germline MTNR1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
4 Benign · 6 Likely benign · 65 Uncertain significance
Full MTNR1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MTNR1B p.Ala100Thr Uncertain significance Single submitter
- MTNR1B p.Ala203Ser Uncertain significance Single submitter
- MTNR1B p.Ala336Val Uncertain significance Single submitter
- MTNR1B p.Ala52Val Uncertain significance Single submitter
- MTNR1B p.Ala74Val Uncertain significance Single submitter
- MTNR1B p.Arg186Cys Uncertain significance Single submitter
- MTNR1B p.Asn304Ser Uncertain significance Single submitter
- MTNR1B p.Asn58Asp Uncertain significance Single submitter
- MTNR1B p.Asn68Lys Uncertain significance Single submitter
- MTNR1B p.Gln313Glu Uncertain significance Single submitter
- MTNR1B p.Glu182Asp Uncertain significance Single submitter
- MTNR1B p.Glu3Asp Uncertain significance Single submitter
- MTNR1B p.Gly105Ser Uncertain significance Single submitter
- MTNR1B p.Gly14Ser Uncertain significance Single submitter
- MTNR1B p.Gly179Val Uncertain significance Single submitter
- MTNR1B p.Gly309Glu Uncertain significance Single submitter
- MTNR1B p.Gly5Ser Uncertain significance Single submitter
- MTNR1B p.His149Gln Uncertain significance Single submitter
- MTNR1B p.Ile142Val Uncertain significance Single submitter
- MTNR1B p.Ile193Asn Uncertain significance Single submitter
- MTNR1B p.Ile306Asn Uncertain significance Single submitter
- MTNR1B p.Ile306Val Uncertain significance Single submitter
- MTNR1B p.Leu166Val Uncertain significance Single submitter
- MTNR1B p.Leu310Phe Uncertain significance Single submitter
- MTNR1B p.Lys338Asn Uncertain significance Single submitter
- MTNR1B p.Phe102Ile Uncertain significance Single submitter
- MTNR1B p.Phe192Ser Uncertain significance Single submitter
- MTNR1B p.Phe7Ile Uncertain significance Single submitter
- MTNR1B p.Pro283Ser Uncertain significance Single submitter
- MTNR1B p.Ser2Ala Uncertain significance Single submitter
- MTNR1B p.Thr292Ile Uncertain significance Single submitter
- MTNR1B p.Tyr141Cys Uncertain significance Single submitter
- MTNR1B p.Tyr200Asp Uncertain significance Single submitter
- MTNR1B p.Tyr298Cys Uncertain significance Single submitter
- MTNR1B p.Val256Ala Uncertain significance Single submitter
- MTNR1B p.Val355Glu Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- MTNR1B p.Ala117Thr Uncertain significance Single submitter
- MTNR1B p.Ala234Asp Uncertain significance Single submitter
- MTNR1B p.Ala265Val Uncertain significance Single submitter
- MTNR1B p.Ala28Val Uncertain significance Single submitter
- MTNR1B p.Arg150Gln Uncertain significance Single submitter
- MTNR1B p.Arg153Gln Uncertain significance Single submitter
- MTNR1B p.Arg153Leu Uncertain significance Single submitter
- MTNR1B p.Arg153Trp Uncertain significance Single submitter
- MTNR1B p.Arg154Cys Uncertain significance Single submitter
- MTNR1B p.Arg231His Likely benign Single submitter
- MTNR1B p.Arg231Ser Uncertain significance Single submitter
- MTNR1B p.Arg316Cys Uncertain significance Single submitter
- MTNR1B p.Cys11Tyr Uncertain significance Single submitter
- MTNR1B p.Cys332Tyr Uncertain significance Single submitter
- MTNR1B p.Glu12Lys Uncertain significance Single submitter
- MTNR1B p.Gly14Asp Uncertain significance Single submitter
- MTNR1B p.Gly15Glu Uncertain significance Single submitter
- MTNR1B p.Ile134Met Uncertain significance Single submitter
- MTNR1B p.Ile270Val Uncertain significance Single submitter
- MTNR1B p.Leu295Ser Uncertain significance Single submitter
- MTNR1B p.Phe118Leu Uncertain significance Single submitter
- MTNR1B p.Pro278Ala Uncertain significance Single submitter
- MTNR1B p.Pro93Ser Uncertain significance Single submitter
- MTNR1B p.Pro93Thr Uncertain significance Single submitter
- MTNR1B p.Ser249Ile Uncertain significance Single submitter
- MTNR1B p.Thr201Ala Uncertain significance Single submitter
- MTNR1B p.Tyr220Phe Uncertain significance Single submitter
- MTNR1B p.Tyr294His Uncertain significance Single submitter
- MTNR1B p.Val215Phe Uncertain significance Single submitter
- MTNR1B p.Val99Met Uncertain significance Single submitter
-
MTNR1B p.Ala325Val
Benign
No assertion criteria
MTNR1B-related disorder
-
MTNR1B p.Thr198Asn
Likely benign
No assertion criteria
MTNR1B-related disorder
All MTNR1B variants
Benign 4
- p.Gly126= Multiple submitters
- p.Ala325Val No assertion criteria MTNR1B-related disorder ⚠
- p.Gly24Glu No assertion criteria MTNR1B-related disorder
- p.Lys243Arg No assertion criteria MTNR1B-related disorder
Likely benign 6
- p.Arg231His Single submitter ⚠
- p.Arg29Gln Single submitter
- p.Thr168= Single submitter
- p.His112= No assertion criteria MTNR1B-related disorder
- p.Leu272= No assertion criteria MTNR1B-related disorder
- p.Thr198Asn No assertion criteria MTNR1B-related disorder ⚠
Uncertain significance 65
- p.Ala100Thr Single submitter ⚠
- p.Ala117Thr Single submitter ⚠
- p.Ala203Ser Single submitter ⚠
- p.Ala234Asp Single submitter ⚠
- p.Ala265Val Single submitter ⚠
- p.Ala28Val Single submitter ⚠
- p.Ala336Val Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Ala74Val Single submitter ⚠
- p.Arg150Gln Single submitter ⚠
- p.Arg153Gln Single submitter ⚠
- p.Arg153Leu Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg154Cys Single submitter ⚠
- p.Arg186Cys Single submitter ⚠
- p.Arg231Ser Single submitter ⚠
- p.Arg316Cys Single submitter ⚠
- p.Asn304Ser Single submitter ⚠
- p.Asn58Asp Single submitter ⚠
- p.Asn68Lys Single submitter ⚠
- p.Cys11Tyr Single submitter ⚠
- p.Cys332Tyr Single submitter ⚠
- p.Gln313Glu Single submitter ⚠
- p.Glu12Lys Single submitter ⚠
- p.Glu182Asp Single submitter ⚠
- p.Glu3Asp Single submitter ⚠
- p.Gly105Ser Single submitter ⚠
- p.Gly14Asp Single submitter ⚠
- p.Gly14Ser Single submitter ⚠
- p.Gly15Glu Single submitter ⚠
- p.Gly179Val Single submitter ⚠
- p.Gly309Glu Single submitter ⚠
- p.Gly5Ser Single submitter ⚠
- p.His149Gln Single submitter ⚠
- p.Ile134Met Single submitter ⚠
- p.Ile142Val Single submitter ⚠
- p.Ile193Asn Single submitter ⚠
- p.Ile270Val Single submitter ⚠
- p.Ile306Asn Single submitter ⚠
- p.Ile306Val Single submitter ⚠
- p.Leu166Val Single submitter ⚠
- p.Leu295Ser Single submitter ⚠
- p.Leu310Phe Single submitter ⚠
- p.Lys338Asn Single submitter ⚠
- p.Phe102Ile Single submitter ⚠
- p.Phe118Leu Single submitter ⚠
- p.Phe192Ser Single submitter ⚠
- p.Phe7Ile Single submitter ⚠
- p.Pro278Ala Single submitter ⚠
- p.Pro283Ser Single submitter ⚠
- p.Pro93Ser Single submitter ⚠
- p.Pro93Thr Single submitter ⚠
- p.Ser249Ile Single submitter ⚠
- p.Ser2Ala Single submitter ⚠
- p.Thr201Ala Single submitter ⚠
- p.Thr292Ile Single submitter ⚠
- p.Tyr141Cys Single submitter ⚠
- p.Tyr200Asp Single submitter ⚠
- p.Tyr220Phe Single submitter ⚠
- p.Tyr294His Single submitter ⚠
- p.Tyr298Cys Single submitter ⚠
- p.Val215Phe Single submitter ⚠
- p.Val256Ala Single submitter ⚠
- p.Val355Glu Single submitter ⚠
- p.Val99Met Single submitter ⚠