MUS81 — 95 ClinVar variants
All ClinVar germline MUS81 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
2 Benign · 5 Likely benign · 88 Uncertain significance
Full MUS81 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MUS81 p.Ala15Ser Uncertain significance Single submitter
- MUS81 p.Ala175Asp Uncertain significance Single submitter
- MUS81 p.Ala253Val Uncertain significance Single submitter
- MUS81 p.Ala413Thr Uncertain significance Single submitter
- MUS81 p.Arg107Gln Uncertain significance Single submitter
- MUS81 p.Arg134Gln Uncertain significance Single submitter
- MUS81 p.Arg134Pro Uncertain significance Single submitter
- MUS81 p.Arg173Thr Uncertain significance Single submitter
- MUS81 p.Arg186His Uncertain significance Single submitter
- MUS81 p.Arg263Lys Uncertain significance Single submitter
- MUS81 p.Arg279Trp Uncertain significance Single submitter
- MUS81 p.Arg355Gln Uncertain significance Single submitter
- MUS81 p.Arg364Gln Uncertain significance Single submitter
- MUS81 p.Arg38Leu Uncertain significance Single submitter
- MUS81 p.Arg38Ser Uncertain significance Single submitter
- MUS81 p.Arg40Leu Uncertain significance Single submitter
- MUS81 p.Arg429His Uncertain significance Single submitter
- MUS81 p.Arg48Cys Uncertain significance Single submitter
- MUS81 p.Asp346Tyr Uncertain significance Single submitter
- MUS81 p.Asp90Gly Uncertain significance Single submitter
- MUS81 p.Cys16Gly Uncertain significance Single submitter
- MUS81 p.Gln214Arg Uncertain significance Single submitter
- MUS81 p.Gln44Arg Uncertain significance Single submitter
- MUS81 p.Gln542Arg Uncertain significance Single submitter
- MUS81 p.Glu208Gly Uncertain significance Single submitter
- MUS81 p.Glu27Gln Uncertain significance Single submitter
- MUS81 p.Glu440Gln Uncertain significance Single submitter
- MUS81 p.Gly125Glu Uncertain significance Single submitter
- MUS81 p.Gly230Arg Uncertain significance Single submitter
- MUS81 p.Gly236Glu Uncertain significance Single submitter
- MUS81 p.Gly282Arg Uncertain significance Single submitter
- MUS81 p.Gly347Ser Uncertain significance Single submitter
- MUS81 p.Gly396Val Uncertain significance Single submitter
- MUS81 p.Gly437Glu Uncertain significance Single submitter
- MUS81 p.His155Pro Uncertain significance Single submitter
- MUS81 p.His295Gln Uncertain significance Single submitter
- MUS81 p.His91Asp Uncertain significance Single submitter
- MUS81 p.Ile331Val Uncertain significance Single submitter
- MUS81 p.Ile344Ser Uncertain significance Single submitter
- MUS81 p.Ile464Thr Uncertain significance Single submitter
- MUS81 p.Leu377Ile Uncertain significance Single submitter
- MUS81 p.Leu419Gln Uncertain significance Single submitter
- MUS81 p.Leu55Pro Uncertain significance Single submitter
- MUS81 p.Met444Val Uncertain significance Single submitter
- MUS81 p.Pro119Leu Uncertain significance Single submitter
- MUS81 p.Pro12Thr Uncertain significance Single submitter
- MUS81 p.Pro183Gln Uncertain significance Single submitter
- MUS81 p.Pro207Leu Uncertain significance Single submitter
- MUS81 p.Pro231Ser Uncertain significance Single submitter
- MUS81 p.Pro380Ser Uncertain significance Single submitter
- MUS81 p.Pro4Leu Uncertain significance Single submitter
- MUS81 p.Pro500Ala Uncertain significance Single submitter
- MUS81 p.Pro513Thr Uncertain significance Single submitter
- MUS81 p.Pro56Leu Uncertain significance Single submitter
- MUS81 p.Pro93Leu Uncertain significance Single submitter
- MUS81 p.Ser101Asn Uncertain significance Single submitter
- MUS81 p.Ser114Cys Uncertain significance Single submitter
- MUS81 p.Ser171Phe Uncertain significance Single submitter
- MUS81 p.Ser382Arg Uncertain significance Single submitter
- MUS81 p.Ser457Arg Uncertain significance Single submitter
- MUS81 p.Thr206Ala Uncertain significance Single submitter
- MUS81 p.Thr315Ser Uncertain significance Single submitter
- MUS81 p.Thr33Asn Uncertain significance Single submitter
- MUS81 p.Thr402Ile Uncertain significance Single submitter
- MUS81 p.Thr522Ser Uncertain significance Single submitter
- MUS81 p.Tyr366Cys Uncertain significance Single submitter
- MUS81 p.Val296Gly Uncertain significance Single submitter
- MUS81 p.Val368Met Uncertain significance Single submitter
- MUS81 p.Val393Ile Uncertain significance Single submitter
- MUS81 p.Val494Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- MUS81 p.Arg293Trp Uncertain significance Single submitter
- MUS81 p.Arg34Gly Uncertain significance Single submitter
- MUS81 p.Arg417Trp Uncertain significance Single submitter
- MUS81 p.Gly484Arg Uncertain significance Single submitter
- MUS81 p.Ile523Asn Uncertain significance Single submitter
- MUS81 p.Leu454Phe Uncertain significance Single submitter
- MUS81 p.Met480Ile Uncertain significance Single submitter
- MUS81 p.Pro264Leu Uncertain significance Single submitter
- MUS81 p.Pro549Leu Uncertain significance Single submitter
- MUS81 p.Ser171Tyr Uncertain significance Single submitter
- MUS81 p.Ser470Leu Benign Single submitter
- MUS81 p.Tyr507Cys Uncertain significance Single submitter
- MUS81 p.Val311Met Uncertain significance Single submitter
- MUS81 p.Val327Ile Uncertain significance Single submitter
All MUS81 variants
Benign 2
- p.Asn390His Multiple submitters
- p.Ser470Leu Single submitter ⚠
Likely benign 5
- p.Arg147Gln Single submitter
- p.Arg363His Single submitter
- p.Cys359= Single submitter
- p.Gly548Ser Single submitter
- p.Leu493= Single submitter
Uncertain significance 88
- c.1401+1G>T Single submitter
- p.Ala15Ser Single submitter ⚠
- p.Ala175Asp Single submitter ⚠
- p.Ala253Val Single submitter ⚠
- p.Ala413Thr Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg134Pro Single submitter ⚠
- p.Arg173Thr Single submitter ⚠
- p.Arg186His Single submitter ⚠
- p.Arg263Lys Single submitter ⚠
- p.Arg279Trp Single submitter ⚠
- p.Arg293Trp Single submitter ⚠
- p.Arg34Gly Single submitter ⚠
- p.Arg355Gln Single submitter ⚠
- p.Arg364Gln Single submitter ⚠
- p.Arg38Leu Single submitter ⚠
- p.Arg38Ser Single submitter ⚠
- p.Arg40Leu Single submitter ⚠
- p.Arg417Trp Single submitter ⚠
- p.Arg429His Single submitter ⚠
- p.Arg48Cys Single submitter ⚠
- p.Asp346Tyr Single submitter ⚠
- p.Asp90Gly Single submitter ⚠
- p.Cys16Gly Single submitter ⚠
- p.Gln214Arg Single submitter ⚠
- p.Gln44Arg Single submitter ⚠
- p.Gln542Arg Single submitter ⚠
- p.Glu208Gly Single submitter ⚠
- p.Glu27Gln Single submitter ⚠
- p.Glu440Gln Single submitter ⚠
- p.Gly125Glu Single submitter ⚠
- p.Gly230Arg Single submitter ⚠
- p.Gly236Glu Single submitter ⚠
- p.Gly282Arg Single submitter ⚠
- p.Gly347Ser Single submitter ⚠
- p.Gly396Val Single submitter ⚠
- p.Gly437Glu Single submitter ⚠
- p.Gly484Arg Single submitter ⚠
- p.His155Pro Single submitter ⚠
- p.His295Gln Single submitter ⚠
- p.His91Asp Single submitter ⚠
- p.Ile331Thr Single submitter
- p.Ile331Val Single submitter ⚠
- p.Ile344Ser Single submitter ⚠
- p.Ile464Thr Single submitter ⚠
- p.Ile523Asn Single submitter ⚠
- p.Leu377Ile Single submitter ⚠
- p.Leu419Gln Single submitter ⚠
- p.Leu453Arg Single submitter
- p.Leu454Phe Single submitter ⚠
- p.Leu55Pro Single submitter ⚠
- p.Met444Val Single submitter ⚠
- p.Met480Ile Single submitter ⚠
- p.Pro119Leu Single submitter ⚠
- p.Pro12Thr Single submitter ⚠
- p.Pro183Gln Single submitter ⚠
- p.Pro207Leu Single submitter ⚠
- p.Pro231Ser Single submitter ⚠
- p.Pro264Leu Single submitter ⚠
- p.Pro380Ser Single submitter ⚠
- p.Pro4Leu Single submitter ⚠
- p.Pro500Ala Single submitter ⚠
- p.Pro513Thr Single submitter ⚠
- p.Pro549Leu Single submitter ⚠
- p.Pro56Leu Single submitter ⚠
- p.Pro93Leu Single submitter ⚠
- p.Ser101Asn Single submitter ⚠
- p.Ser114Cys Single submitter ⚠
- p.Ser171Phe Single submitter ⚠
- p.Ser171Tyr Single submitter ⚠
- p.Ser382Arg Single submitter ⚠
- p.Ser457Arg Single submitter ⚠
- p.Thr206Ala Single submitter ⚠
- p.Thr315Ser Single submitter ⚠
- p.Thr33Asn Single submitter ⚠
- p.Thr402Ile Single submitter ⚠
- p.Thr416Met Single submitter
- p.Thr522Ser Single submitter ⚠
- p.Tyr366Cys Single submitter ⚠
- p.Tyr507Cys Single submitter ⚠
- p.Val296Gly Single submitter ⚠
- p.Val296Leu Single submitter
- p.Val311Met Single submitter ⚠
- p.Val327Ile Single submitter ⚠
- p.Val368Met Single submitter ⚠
- p.Val393Ile Single submitter ⚠
- p.Val494Leu Single submitter ⚠