MYB — 84 ClinVar variants
All ClinVar germline MYB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
11 Benign · 1 Benign/Likely benign · 10 Likely benign · 62 Uncertain significance
Full MYB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MYB p.Ala278Thr Uncertain significance Single submitter
- MYB p.Ala719Glu Uncertain significance Single submitter
- MYB p.Arg337Gly Uncertain significance Single submitter
- MYB p.Arg757Gln Uncertain significance Single submitter
- MYB p.Asn532Asp Uncertain significance Single submitter
- MYB p.Asp178Gly Uncertain significance Single submitter
- MYB p.Asp18Ala Uncertain significance Single submitter
- MYB p.Asp559Glu Uncertain significance Single submitter
- MYB p.Cys322Trp Uncertain significance Single submitter
- MYB p.Cys322Tyr Uncertain significance Single submitter
- MYB p.Cys734Tyr Uncertain significance Single submitter
- MYB p.Gln157Arg Uncertain significance Single submitter
- MYB p.Glu150Asp Uncertain significance Single submitter
- MYB p.Glu652Ala Uncertain significance Single submitter
- MYB p.His335Gln Uncertain significance Single submitter
- MYB p.His593Arg Uncertain significance Single submitter
- MYB p.Ile576Val Uncertain significance Single submitter
- MYB p.Leu545Val Uncertain significance Single submitter
- MYB p.Lys216Arg Uncertain significance Single submitter
- MYB p.Lys606Arg Uncertain significance Single submitter
- MYB p.Lys606Gln Uncertain significance Single submitter
- MYB p.Lys646Arg Uncertain significance Single submitter
- MYB p.Met607Leu Uncertain significance Single submitter
- MYB p.Phe398Cys Uncertain significance Single submitter
- MYB p.Pro260Ala Uncertain significance Single submitter
- MYB p.Pro355Leu Uncertain significance Single submitter
- MYB p.Pro361Ala Uncertain significance Single submitter
- MYB p.Pro687Ser Uncertain significance Single submitter
- MYB p.Ser539Pro Uncertain significance Single submitter
- MYB p.Ser613Cys Uncertain significance Single submitter
- MYB p.Ser700Thr Uncertain significance Single submitter
- MYB p.Ser743Pro Uncertain significance Single submitter
- MYB p.Ser745Thr Uncertain significance Single submitter
- MYB p.Thr551Ala Uncertain significance Single submitter
- MYB p.Thr569Ala Uncertain significance Single submitter
- MYB p.Thr589Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- MYB p.Arg4Ser Uncertain significance Single submitter
- MYB p.Arg586Gly Uncertain significance Single submitter
- MYB p.His121Arg Uncertain significance Single submitter
- MYB p.Lys566Asn Uncertain significance Single submitter
- MYB p.Phe677Leu Uncertain significance Single submitter
- MYB p.Pro544His Uncertain significance Single submitter
- MYB p.Pro612Leu Uncertain significance Single submitter
All MYB variants
Benign 11
- c.1825-6G>T Single submitter
- c.214-10_214-7del Single submitter
- p.Ala634= Single submitter
- p.Cys374= Single submitter
- p.Lys592= Single submitter
- p.Ser250= Single submitter
- p.Ser405Pro Single submitter
- p.Thr305= Single submitter
- p.Thr336Ile Single submitter
- p.Thr543Asn Single submitter
- p.Arg757= No assertion criteria MYB-related disorder
Benign/Likely benign 1
- p.Thr589= Multiple submitters
Likely benign 10
- c.307-6C>T Single submitter
- p.Ala359Val Single submitter
- p.Ile499Leu Single submitter
- p.Leu707= Single submitter
- p.Met737Thr Single submitter
- p.Ser727Gly Single submitter
- p.Glu629Ala No assertion criteria MYB-related disorder
- p.Gly631Glu No assertion criteria MYB-related disorder
- p.Pro361= No assertion criteria MYB-related disorder
- p.Tyr110= No assertion criteria MYB-related disorder
Uncertain significance 62
- p.Ala278Thr Single submitter ⚠
- p.Ala470Ser Single submitter
- p.Ala491Asp Single submitter
- p.Ala719Glu Single submitter ⚠
- p.Arg337Gly Single submitter ⚠
- p.Arg484Trp Single submitter
- p.Arg4Ser Single submitter ⚠
- p.Arg510Cys Single submitter
- p.Arg586Gly Single submitter ⚠
- p.Arg757Gln Single submitter ⚠
- p.Asn439Ile Single submitter
- p.Asn532Asp Single submitter ⚠
- p.Asp178fs Single submitter MYB-related disorder
- p.Asp178Gly Single submitter ⚠
- p.Asp18Ala Single submitter ⚠
- p.Asp559Glu Single submitter ⚠
- p.Asp559His Single submitter
- p.Cys322Trp Single submitter ⚠
- p.Cys322Tyr Single submitter ⚠
- p.Cys734Tyr Single submitter ⚠
- p.Gln157Arg Single submitter ⚠
- p.Gln200Leu Single submitter
- p.Gln435Lys Single submitter
- p.Glu150Asp Single submitter ⚠
- p.Glu652Ala Single submitter ⚠
- p.His121Arg Single submitter ⚠
- p.His335Gln Single submitter ⚠
- p.His593Arg Single submitter ⚠
- p.Ile576Val Single submitter ⚠
- p.Leu477Pro Single submitter
- p.Leu545Val Single submitter ⚠
- p.Lys216Arg Single submitter ⚠
- p.Lys566Asn Single submitter ⚠
- p.Lys606Arg Single submitter ⚠
- p.Lys606Gln Single submitter ⚠
- p.Lys646Arg Single submitter ⚠
- p.Met455Ile Single submitter
- p.Met607Leu Single submitter ⚠
- p.Phe398Cys Single submitter ⚠
- p.Phe414Leu Single submitter
- p.Phe677Leu Single submitter ⚠
- p.Pro260Ala Single submitter ⚠
- p.Pro355Leu Single submitter ⚠
- p.Pro361Ala Single submitter ⚠
- p.Pro447Arg Single submitter
- p.Pro447Thr Single submitter
- p.Pro517Leu Single submitter
- p.Pro544His Single submitter ⚠
- p.Pro612Leu Single submitter ⚠
- p.Pro687Ser Single submitter ⚠
- p.Ser403Phe Single submitter
- p.Ser488Cys Single submitter
- p.Ser515Ile Single submitter
- p.Ser539Pro Single submitter ⚠
- p.Ser613Cys Single submitter ⚠
- p.Ser700Thr Single submitter ⚠
- p.Ser743Pro Single submitter ⚠
- p.Ser745Thr Single submitter ⚠
- p.Thr551Ala Single submitter ⚠
- p.Thr569Ala Single submitter ⚠
- p.Thr589Ile Single submitter ⚠
- p.Val503Ile Single submitter