Sugi Variant

Sugi Variant/MYH14

MYH14 — 1576 ClinVar variants

All ClinVar germline MYH14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 738 flagged for review →

17 Pathogenic · 1 Pathogenic/Likely pathogenic · 16 Likely pathogenic · 117 Conflicting · 169 Benign · 61 Benign/Likely benign · 370 Likely benign · 825 Uncertain significance

Full MYH14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 738

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 45

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 471

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 471

Predictors split 221

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 221

All MYH14 variants

Pathogenic 17

Pathogenic/Likely pathogenic 1

Likely pathogenic 16

Conflicting classifications of pathogenicity 117

Benign 169

Benign/Likely benign 61

Likely benign 370

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 825

Showing the top 300 by review status; the full set is in the sitemap.