Sugi Variant

Sugi Variant/MYLK3

MYLK3 — 1007 ClinVar variants

All ClinVar germline MYLK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 545 flagged for review →

1 Likely pathogenic · 24 Conflicting · 19 Benign · 3 Benign/Likely benign · 318 Likely benign · 642 Uncertain significance

Full MYLK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 545

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 20

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 477

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 477

Predictors split 48

The independent predictors disagree with each other — read with care.

All MYLK3 variants

Likely pathogenic 1

Conflicting classifications of pathogenicity 24

Benign 19

Benign/Likely benign 3

Likely benign 318

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 642

Showing the top 300 by review status; the full set is in the sitemap.