MYLK4 — 59 ClinVar variants
All ClinVar germline MYLK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
6 Likely benign · 53 Uncertain significance
Full MYLK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MYLK4 p.Ala271Asp Uncertain significance Single submitter
- MYLK4 p.Ala271Thr Uncertain significance Single submitter
- MYLK4 p.Ala54Val Uncertain significance Single submitter
- MYLK4 p.Ala78Ser Uncertain significance Single submitter
- MYLK4 p.Arg216Met Uncertain significance Single submitter
- MYLK4 p.Arg257Lys Uncertain significance Single submitter
- MYLK4 p.Arg378His Uncertain significance Single submitter
- MYLK4 p.Arg91Ser Uncertain significance Single submitter
- MYLK4 p.Asn17Lys Uncertain significance Single submitter
- MYLK4 p.Asp247Tyr Uncertain significance Single submitter
- MYLK4 p.Asp308Gly Uncertain significance Single submitter
- MYLK4 p.Asp381Tyr Uncertain significance Single submitter
- MYLK4 p.Asp62Asn Uncertain significance Single submitter
- MYLK4 p.Asp89Asn Uncertain significance Single submitter
- MYLK4 p.Cys13Tyr Uncertain significance Single submitter
- MYLK4 p.Cys235Arg Uncertain significance Single submitter
- MYLK4 p.Gln210His Uncertain significance Single submitter
- MYLK4 p.Glu171Lys Uncertain significance Single submitter
- MYLK4 p.Gly129Ser Uncertain significance Single submitter
- MYLK4 p.His225Tyr Uncertain significance Single submitter
- MYLK4 p.Ile164Thr Uncertain significance Single submitter
- MYLK4 p.Leu188Met Uncertain significance Single submitter
- MYLK4 p.Leu234Gln Uncertain significance Single submitter
- MYLK4 p.Leu342Pro Uncertain significance Single submitter
- MYLK4 p.Lys376Asn Uncertain significance Single submitter
- MYLK4 p.Pro68Ser Uncertain significance Single submitter
- MYLK4 p.Pro84Ser Uncertain significance Single submitter
- MYLK4 p.Pro85Leu Uncertain significance Single submitter
- MYLK4 p.Ser298Arg Uncertain significance Single submitter
- MYLK4 p.Ser71Arg Uncertain significance Single submitter
- MYLK4 p.Thr105Ile Uncertain significance Single submitter
- MYLK4 p.Thr139Ser Uncertain significance Single submitter
- MYLK4 p.Thr311Met Uncertain significance Single submitter
- MYLK4 p.Tyr14Cys Uncertain significance Single submitter
- MYLK4 p.Val120Phe Uncertain significance Single submitter
- MYLK4 p.Val69Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- MYLK4 p.Arg191Cys Uncertain significance Single submitter
- MYLK4 p.Arg378Pro Uncertain significance Single submitter
- MYLK4 p.Asn150Asp Uncertain significance Single submitter
- MYLK4 p.Asn313Lys Uncertain significance Single submitter
- MYLK4 p.Asp190His Uncertain significance Single submitter
- MYLK4 p.Asp194Asn Uncertain significance Single submitter
- MYLK4 p.Asp306Val Uncertain significance Single submitter
- MYLK4 p.Asp329Tyr Uncertain significance Single submitter
- MYLK4 p.Gln119Arg Uncertain significance Single submitter
- MYLK4 p.Leu297Ile Uncertain significance Single submitter
- MYLK4 p.Lys335Glu Uncertain significance Single submitter
- MYLK4 p.Pro283Arg Uncertain significance Single submitter
- MYLK4 p.Thr139Asn Uncertain significance Single submitter
- MYLK4 p.Thr200Met Uncertain significance Single submitter
All MYLK4 variants
Likely benign 6
- p.Ala161Val Single submitter
- p.Ala78Thr Single submitter
- p.Arg253= Single submitter
- p.Tyr197Cys Single submitter
- p.Val154Ile Single submitter
- p.Glu151Lys No assertion criteria long QT syndrome
Uncertain significance 53
- p.Ala271Asp Single submitter ⚠
- p.Ala271Thr Single submitter ⚠
- p.Ala54Val Single submitter ⚠
- p.Ala78Ser Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg216Met Single submitter ⚠
- p.Arg257Lys Single submitter ⚠
- p.Arg378His Single submitter ⚠
- p.Arg378Pro Single submitter ⚠
- p.Arg91His Single submitter
- p.Arg91Ser Single submitter ⚠
- p.Asn150Asp Single submitter ⚠
- p.Asn17Lys Single submitter ⚠
- p.Asn313Lys Single submitter ⚠
- p.Asp190His Single submitter ⚠
- p.Asp194Asn Single submitter ⚠
- p.Asp247Tyr Single submitter ⚠
- p.Asp306Val Single submitter ⚠
- p.Asp308Gly Single submitter ⚠
- p.Asp329Tyr Single submitter ⚠
- p.Asp381Tyr Single submitter ⚠
- p.Asp62Asn Single submitter ⚠
- p.Asp89Asn Single submitter ⚠
- p.Cys13Tyr Single submitter ⚠
- p.Cys235Arg Single submitter ⚠
- p.Gln119Arg Single submitter ⚠
- p.Gln210His Single submitter ⚠
- p.Glu171Lys Single submitter ⚠
- p.Gly129Ser Single submitter ⚠
- p.Gly299Ser Single submitter
- p.His225Tyr Single submitter ⚠
- p.His358Tyr Single submitter
- p.Ile164Thr Single submitter ⚠
- p.Leu188Met Single submitter ⚠
- p.Leu234Gln Single submitter ⚠
- p.Leu297Ile Single submitter ⚠
- p.Leu342Pro Single submitter ⚠
- p.Lys335Glu Single submitter ⚠
- p.Lys376Asn Single submitter ⚠
- p.Pro283Arg Single submitter ⚠
- p.Pro68Ser Single submitter ⚠
- p.Pro84Ser Single submitter ⚠
- p.Pro85Leu Single submitter ⚠
- p.Ser298Arg Single submitter ⚠
- p.Ser71Arg Single submitter ⚠
- p.Thr105Ile Single submitter ⚠
- p.Thr139Asn Single submitter ⚠
- p.Thr139Ser Single submitter ⚠
- p.Thr200Met Single submitter ⚠
- p.Thr311Met Single submitter ⚠
- p.Tyr14Cys Single submitter ⚠
- p.Val120Phe Single submitter ⚠
- p.Val69Ala Single submitter ⚠