MYO1B — 124 ClinVar variants
All ClinVar germline MYO1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
1 Pathogenic · 4 Benign · 1 Likely benign · 118 Uncertain significance
Full MYO1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 90
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MYO1B p.Ala215Thr Uncertain significance Single submitter
- MYO1B p.Ala257Val Uncertain significance Single submitter
- MYO1B p.Ala735Thr Uncertain significance Single submitter
- MYO1B p.Ala742Val Uncertain significance Single submitter
- MYO1B p.Ala754Thr Uncertain significance Single submitter
- MYO1B p.Ala835Thr Uncertain significance Single submitter
- MYO1B p.Ala842Thr Uncertain significance Single submitter
- MYO1B p.Arg1006Trp Uncertain significance Single submitter
- MYO1B p.Arg227Thr Uncertain significance Single submitter
- MYO1B p.Arg38Cys Uncertain significance Single submitter
- MYO1B p.Arg498Gln Uncertain significance Single submitter
- MYO1B p.Arg644Gly Uncertain significance Single submitter
- MYO1B p.Arg688Gln Uncertain significance Single submitter
- MYO1B p.Arg716Gln Uncertain significance Single submitter
- MYO1B p.Arg739Gly Uncertain significance Single submitter
- MYO1B p.Arg746Lys Uncertain significance Single submitter
- MYO1B p.Arg825Pro Uncertain significance Single submitter
- MYO1B p.Arg96Gln Uncertain significance Single submitter
- MYO1B p.Asn1012Ser Uncertain significance Single submitter
- MYO1B p.Asn1117Ser Uncertain significance Single submitter
- MYO1B p.Asn1128Ser Uncertain significance Single submitter
- MYO1B p.Asn146Lys Uncertain significance Single submitter
- MYO1B p.Asn501Ser Uncertain significance Single submitter
- MYO1B p.Asn599Ser Uncertain significance Single submitter
- MYO1B p.Asn608Ser Uncertain significance Single submitter
- MYO1B p.Asn864Ser Uncertain significance Single submitter
- MYO1B p.Asn971Lys Uncertain significance Single submitter
- MYO1B p.Asp1068Tyr Uncertain significance Single submitter
- MYO1B p.Asp932Gly Uncertain significance Single submitter
- MYO1B p.Gln144Arg Uncertain significance Single submitter
- MYO1B p.Gln413Arg Uncertain significance Single submitter
- MYO1B p.Gln961Leu Uncertain significance Single submitter
- MYO1B p.Glu425Asp Uncertain significance Single submitter
- MYO1B p.Glu430Ala Uncertain significance Single submitter
- MYO1B p.Glu609Lys Uncertain significance Single submitter
- MYO1B p.Gly1118Arg Uncertain significance Single submitter
- MYO1B p.Gly314Ser Uncertain significance Single submitter
- MYO1B p.Gly960Glu Uncertain significance Single submitter
- MYO1B p.His486Tyr Uncertain significance Single submitter
- MYO1B p.His791Arg Uncertain significance Single submitter
- MYO1B p.His791Gln Uncertain significance Single submitter
- MYO1B p.Ile1025Val Uncertain significance Single submitter
- MYO1B p.Ile1111Met Uncertain significance Single submitter
- MYO1B p.Ile593Val Uncertain significance Single submitter
- MYO1B p.Ile606Leu Uncertain significance Single submitter
- MYO1B p.Ile761Leu Uncertain significance Single submitter
- MYO1B p.Ile812Val Uncertain significance Single submitter
- MYO1B p.Leu386Met Uncertain significance Single submitter
- MYO1B p.Leu696Ser Uncertain significance Single submitter
- MYO1B p.Leu726Pro Uncertain significance Single submitter
- MYO1B p.Leu936Arg Uncertain significance Single submitter
- MYO1B p.Leu936Phe Uncertain significance Single submitter
- MYO1B p.Lys1036Arg Uncertain significance Single submitter
- MYO1B p.Lys657Gln Uncertain significance Single submitter
- MYO1B p.Lys68Thr Uncertain significance Single submitter
- MYO1B p.Lys751Gln Uncertain significance Single submitter
- MYO1B p.Lys838Glu Uncertain significance Single submitter
- MYO1B p.Lys972Thr Uncertain significance Single submitter
- MYO1B p.Met1073Thr Uncertain significance Single submitter
- MYO1B p.Met889Leu Uncertain significance Single submitter
- MYO1B p.Phe174Cys Uncertain significance Single submitter
- MYO1B p.Phe554Cys Uncertain significance Single submitter
- MYO1B p.Pro147Leu Uncertain significance Single submitter
- MYO1B p.Pro555Ser Uncertain significance Single submitter
- MYO1B p.Pro57Leu Uncertain significance Single submitter
- MYO1B p.Pro62Ser Uncertain significance Single submitter
- MYO1B p.Pro690Ser Uncertain significance Single submitter
- MYO1B p.Pro956Leu Uncertain significance Single submitter
- MYO1B p.Ser1027Leu Uncertain significance Single submitter
- MYO1B p.Ser683Thr Uncertain significance Single submitter
- MYO1B p.Ser901Leu Uncertain significance Single submitter
- MYO1B p.Thr1035Ala Uncertain significance Single submitter
- MYO1B p.Thr1081Ile Uncertain significance Single submitter
- MYO1B p.Thr30Asn Uncertain significance Single submitter
- MYO1B p.Thr313Ala Uncertain significance Single submitter
- MYO1B p.Thr471Ile Uncertain significance Single submitter
- MYO1B p.Thr569Ile Uncertain significance Single submitter
- MYO1B p.Thr750Ala Uncertain significance Single submitter
- MYO1B p.Thr793Ile Uncertain significance Single submitter
- MYO1B p.Trp737Ser Uncertain significance Single submitter
- MYO1B p.Tyr124Cys Uncertain significance Single submitter
- MYO1B p.Tyr638Asp Uncertain significance Single submitter
- MYO1B p.Tyr645Cys Uncertain significance Single submitter
- MYO1B p.Tyr715Phe Uncertain significance Single submitter
- MYO1B p.Val1032Met Uncertain significance Single submitter
- MYO1B p.Val1135Ile Uncertain significance Single submitter
- MYO1B p.Val128Ile Uncertain significance Single submitter
- MYO1B p.Val527Ile Uncertain significance Single submitter
- MYO1B p.Val675Met Uncertain significance Single submitter
- MYO1B p.Val841Ile Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- MYO1B p.Ala86Ser Uncertain significance Single submitter
- MYO1B p.Arg367Gln Uncertain significance Single submitter
- MYO1B p.Arg59Trp Uncertain significance Single submitter
- MYO1B p.Arg703Cys Uncertain significance Single submitter
- MYO1B p.Arg762Gln Uncertain significance Single submitter
- MYO1B p.Arg771Trp Uncertain significance Single submitter
- MYO1B p.Arg797Thr Uncertain significance Single submitter
- MYO1B p.Cys1107Arg Uncertain significance Single submitter
- MYO1B p.Glu311Gly Uncertain significance Single submitter
- MYO1B p.Glu490Gly Uncertain significance Single submitter
- MYO1B p.Glu834Ala Uncertain significance Single submitter
- MYO1B p.Gly525Arg Uncertain significance Single submitter
- MYO1B p.His547Arg Uncertain significance Single submitter
- MYO1B p.His911Gln Uncertain significance Single submitter
- MYO1B p.Ile416Val Uncertain significance Single submitter
- MYO1B p.Leu220Arg Uncertain significance Single submitter
- MYO1B p.Lys852Gln Uncertain significance Single submitter
- MYO1B p.Phe286Leu Uncertain significance Single submitter
- MYO1B p.Phe930Leu Uncertain significance Single submitter
- MYO1B p.Ser270Tyr Uncertain significance Single submitter
- MYO1B p.Ser679Phe Uncertain significance Single submitter
- MYO1B p.Thr339Ile Uncertain significance Single submitter
- MYO1B p.Val814Ala Uncertain significance Single submitter
All MYO1B variants
Pathogenic 1
- p.Lys925fs No assertion criteria colorectal cancer
Benign 4
- p.Arg825Gln Multiple submitters
- p.Gln744= Multiple submitters
- p.Pro598= Multiple submitters
- p.Leu80= Single submitter
Likely benign 1
- p.Val1049Ile Single submitter
Uncertain significance 118
- p.Ala215Thr Single submitter ⚠
- p.Ala257Val Single submitter ⚠
- p.Ala735Thr Single submitter ⚠
- p.Ala742Val Single submitter ⚠
- p.Ala754Thr Single submitter ⚠
- p.Ala835Thr Single submitter ⚠
- p.Ala842Thr Single submitter ⚠
- p.Ala86Ser Single submitter ⚠
- p.Arg1006Trp Single submitter ⚠
- p.Arg227Ser Single submitter
- p.Arg227Thr Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Arg38Cys Single submitter ⚠
- p.Arg498Gln Single submitter ⚠
- p.Arg59Trp Single submitter ⚠
- p.Arg644Gly Single submitter ⚠
- p.Arg688Gln Single submitter ⚠
- p.Arg703Cys Single submitter ⚠
- p.Arg716Gln Single submitter ⚠
- p.Arg721Cys Single submitter
- p.Arg739Gly Single submitter ⚠
- p.Arg746Lys Single submitter ⚠
- p.Arg762Gln Single submitter ⚠
- p.Arg771Trp Single submitter ⚠
- p.Arg797Thr Single submitter ⚠
- p.Arg825Pro Single submitter ⚠
- p.Arg96Gln Single submitter ⚠
- p.Asn1012Ser Single submitter ⚠
- p.Asn1117Ser Single submitter ⚠
- p.Asn1128Ser Single submitter ⚠
- p.Asn146Lys Single submitter ⚠
- p.Asn501Ser Single submitter ⚠
- p.Asn599Ser Single submitter ⚠
- p.Asn608Ser Single submitter ⚠
- p.Asn864Ser Single submitter ⚠
- p.Asn971Lys Single submitter ⚠
- p.Asp1068Tyr Single submitter ⚠
- p.Asp932Gly Single submitter ⚠
- p.Cys1107Arg Single submitter ⚠
- p.Gln144Arg Single submitter ⚠
- p.Gln413Arg Single submitter ⚠
- p.Gln961Leu Single submitter ⚠
- p.Glu311Gly Single submitter ⚠
- p.Glu425Asp Single submitter ⚠
- p.Glu430Ala Single submitter ⚠
- p.Glu490Gly Single submitter ⚠
- p.Glu609Lys Single submitter ⚠
- p.Glu834Ala Single submitter ⚠
- p.Gly1118Arg Single submitter ⚠
- p.Gly314Ser Single submitter ⚠
- p.Gly525Arg Single submitter ⚠
- p.Gly960Glu Single submitter ⚠
- p.His486Tyr Single submitter ⚠
- p.His547Arg Single submitter ⚠
- p.His791Arg Single submitter ⚠
- p.His791Gln Single submitter ⚠
- p.His839Leu Single submitter
- p.His911Gln Single submitter ⚠
- p.Ile1025Val Single submitter ⚠
- p.Ile1111Met Single submitter ⚠
- p.Ile416Val Single submitter ⚠
- p.Ile593Val Single submitter ⚠
- p.Ile606Leu Single submitter ⚠
- p.Ile761Leu Single submitter ⚠
- p.Ile812Val Single submitter ⚠
- p.Leu220Arg Single submitter ⚠
- p.Leu386Met Single submitter ⚠
- p.Leu696Ser Single submitter ⚠
- p.Leu726Pro Single submitter ⚠
- p.Leu849Phe Single submitter
- p.Leu936Arg Single submitter ⚠
- p.Leu936Phe Single submitter ⚠
- p.Lys1036Arg Single submitter ⚠
- p.Lys657Gln Single submitter ⚠
- p.Lys68Thr Single submitter ⚠
- p.Lys751Gln Single submitter ⚠
- p.Lys838Glu Single submitter ⚠
- p.Lys852Gln Single submitter ⚠
- p.Lys972Thr Single submitter ⚠
- p.Met1073Thr Single submitter ⚠
- p.Met889Leu Single submitter ⚠
- p.Phe174Cys Single submitter ⚠
- p.Phe286Leu Single submitter ⚠
- p.Phe554Cys Single submitter ⚠
- p.Phe930Leu Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro555Ser Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Pro62Ser Single submitter ⚠
- p.Pro690Ser Single submitter ⚠
- p.Pro956Leu Single submitter ⚠
- p.Ser1027Leu Single submitter ⚠
- p.Ser270Tyr Single submitter ⚠
- p.Ser679Phe Single submitter ⚠
- p.Ser683Thr Single submitter ⚠
- p.Ser901Leu Single submitter ⚠
- p.Thr1035Ala Single submitter ⚠
- p.Thr1081Ile Single submitter ⚠
- p.Thr30Asn Single submitter ⚠
- p.Thr313Ala Single submitter ⚠
- p.Thr338Ala Single submitter
- p.Thr339Ile Single submitter ⚠
- p.Thr471Ile Single submitter ⚠
- p.Thr569Ile Single submitter ⚠
- p.Thr750Ala Single submitter ⚠
- p.Thr793Ile Single submitter ⚠
- p.Trp737Ser Single submitter ⚠
- p.Tyr124Cys Single submitter ⚠
- p.Tyr638Asp Single submitter ⚠
- p.Tyr645Cys Single submitter ⚠
- p.Tyr715Phe Single submitter ⚠
- p.Val1032Met Single submitter ⚠
- p.Val1135Ile Single submitter ⚠
- p.Val128Ile Single submitter ⚠
- p.Val527Ile Single submitter ⚠
- p.Val675Met Single submitter ⚠
- p.Val814Ala Single submitter ⚠
- p.Val841Ile Single submitter ⚠