MYO1G — 173 ClinVar variants

All ClinVar germline MYO1G variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 162 flagged for review →

5 Likely benign · 168 Uncertain significance

Full MYO1G gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 162

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 125

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 37

The independent predictors disagree with each other — read with care.

All MYO1G variants

Likely benign 5

p.Arg1018= Single submitter
p.His678Asn Single submitter
p.Thr240Ile Single submitter
p.Thr441Ala Single submitter
p.Tyr768= Single submitter

Uncertain significance 168

p.Ala226Val Single submitter ⚠
p.Ala254Thr Single submitter ⚠
p.Ala258Val Single submitter ⚠
p.Ala328Val Single submitter ⚠
p.Ala451Thr Single submitter ⚠
p.Ala623Thr Single submitter ⚠
p.Ala64Ser Single submitter ⚠
p.Ala726Val Single submitter ⚠
p.Ala750Thr Single submitter ⚠
p.Ala750Val Single submitter ⚠
p.Ala779Val Single submitter ⚠
p.Ala790Thr Single submitter ⚠
p.Ala814Val Single submitter ⚠
p.Ala834Thr Single submitter ⚠
p.Ala963Thr Single submitter ⚠
p.Arg152Cys Single submitter ⚠
p.Arg155Cys Single submitter ⚠
p.Arg161Cys Single submitter ⚠
p.Arg274His Single submitter ⚠
p.Arg319Gln Single submitter ⚠
p.Arg319Trp Single submitter ⚠
p.Arg324Cys Single submitter ⚠
p.Arg329Cys Single submitter ⚠
p.Arg362Gln Single submitter ⚠
p.Arg362Trp Single submitter ⚠
p.Arg378Gln Single submitter ⚠
p.Arg378Trp Single submitter ⚠
p.Arg37Cys Single submitter ⚠
p.Arg380Trp Single submitter ⚠
p.Arg383Trp Single submitter ⚠
p.Arg384His Single submitter ⚠
p.Arg459Gln Single submitter ⚠
p.Arg459Trp Single submitter ⚠
p.Arg462His Single submitter ⚠
p.Arg481Gln Single submitter ⚠
p.Arg492His Single submitter ⚠
p.Arg513Gln Single submitter ⚠
p.Arg513Leu Single submitter ⚠
p.Arg516Gln Single submitter ⚠
p.Arg600Cys Single submitter ⚠
p.Arg729His Single submitter ⚠
p.Arg731Gln Single submitter ⚠
p.Arg731Trp Single submitter ⚠
p.Arg741His Single submitter ⚠
p.Arg744Trp Single submitter ⚠
p.Arg74Trp Single submitter ⚠
p.Arg757Gln Single submitter ⚠
p.Arg757Leu Single submitter ⚠
p.Arg757Trp Single submitter ⚠
p.Arg758Gln Single submitter ⚠
p.Arg796Gln Single submitter ⚠
p.Arg796Trp Single submitter ⚠
p.Arg798Gln Single submitter ⚠
p.Arg826His Single submitter ⚠
p.Arg837Gln Single submitter ⚠
p.Arg876Leu Single submitter ⚠
p.Arg885Gln Single submitter ⚠
p.Arg885Trp Single submitter ⚠
p.Arg92Gln Single submitter ⚠
p.Arg92Trp Single submitter ⚠
p.Arg934Cys Single submitter ⚠
p.Arg94Gly Single submitter ⚠
p.Asn590Thr Single submitter ⚠
p.Asn803Ser Single submitter ⚠
p.Asp213Asn Single submitter ⚠
p.Asp533Asn Single submitter ⚠
p.Asp537Val Single submitter ⚠
p.Asp607Glu Single submitter ⚠
p.Asp667Asn Single submitter ⚠
p.Asp828Glu Single submitter ⚠
p.Asp864Asn Single submitter ⚠
p.Asp893His Single submitter
p.Cys618Tyr Single submitter ⚠
p.Gln117Pro Single submitter ⚠
p.Gln485His Single submitter ⚠
p.Gln485Lys Single submitter ⚠
p.Gln785Pro Single submitter
p.Gln894Lys Single submitter ⚠
p.Gln936Leu Single submitter ⚠
p.Gln966Arg Single submitter ⚠
p.Glu218Ala Single submitter ⚠
p.Glu257Lys Single submitter ⚠
p.Glu305Gln Single submitter ⚠
p.Glu408Lys Single submitter ⚠
p.Glu438Lys Single submitter ⚠
p.Glu458Ala Single submitter ⚠
p.Glu568Gly Single submitter ⚠
p.Glu5Lys Single submitter ⚠
p.Glu606Lys Single submitter ⚠
p.Glu615Asp Single submitter ⚠
p.Glu61Gly Single submitter ⚠
p.Glu61Lys Single submitter ⚠
p.Glu994Asp Single submitter ⚠
p.Gly174Trp Single submitter ⚠
p.Gly178Arg Single submitter ⚠
p.Gly335Ala Single submitter ⚠
p.Gly679Arg Single submitter ⚠
p.Gly6Ser Single submitter ⚠
p.Gly769Arg Single submitter ⚠
p.Gly969Ser Single submitter ⚠
p.His232Asn Single submitter ⚠
p.His273Arg Single submitter ⚠
p.His281Pro Single submitter ⚠
p.His617Asp Single submitter ⚠
p.His746Tyr Single submitter ⚠
p.His874Tyr Single submitter ⚠
p.His91Gln Single submitter ⚠
p.Ile115Asn Single submitter ⚠
p.Ile339Val Single submitter ⚠
p.Ile391Thr Single submitter ⚠
p.Ile424Val Single submitter
p.Ile42Val Single submitter ⚠
p.Ile739Val Single submitter ⚠
p.Leu16Phe Single submitter ⚠
p.Leu276Met Single submitter ⚠
p.Leu426Ile Single submitter
p.Leu468Val Single submitter ⚠
p.Leu502His Single submitter ⚠
p.Leu57Pro Single submitter ⚠
p.Leu71Pro Single submitter ⚠
p.Leu776Val Single submitter ⚠
p.Leu943Pro Single submitter ⚠
p.Lys603Arg Single submitter ⚠
p.Met259Val Single submitter ⚠
p.Met809Thr Single submitter ⚠
p.Met819Ile Single submitter ⚠
p.Phe14Ser Single submitter ⚠
p.Phe204Val Single submitter ⚠
p.Phe423Leu Single submitter ⚠
p.Pro1000Leu Single submitter ⚠
p.Pro1002Ser Single submitter ⚠
p.Pro1016Arg Single submitter ⚠
p.Pro604Leu Single submitter ⚠
p.Pro765Leu Single submitter ⚠
p.Pro76Leu Single submitter ⚠
p.Pro806His Single submitter ⚠
p.Pro810His Single submitter ⚠
p.Ser159Cys Single submitter ⚠
p.Ser325Ala Single submitter ⚠
p.Ser473Gly Single submitter ⚠
p.Thr256Ile Single submitter ⚠
p.Thr290Met Single submitter ⚠
p.Thr315Arg Single submitter ⚠
p.Thr441Ile Single submitter ⚠
p.Thr477Ala Single submitter ⚠
p.Thr479Ser Single submitter ⚠
p.Thr551Ala Single submitter ⚠
p.Thr551Met Single submitter ⚠
p.Thr575Met Single submitter ⚠
p.Thr96Ser Single submitter ⚠
p.Trp742Arg Single submitter ⚠
p.Tyr768Cys Single submitter ⚠
p.Val137Gly Single submitter
p.Val191Ile Single submitter ⚠
p.Val196Met Single submitter ⚠
p.Val272Ala Single submitter ⚠
p.Val322Met Single submitter ⚠
p.Val390Ile Single submitter ⚠
p.Val393Met Single submitter ⚠
p.Val404Ile Single submitter ⚠
p.Val467Met Single submitter ⚠
p.Val528Met Single submitter ⚠
p.Val599Ile Single submitter ⚠
p.Val622Ile Single submitter ⚠
p.Val671Met Single submitter
p.Val684Met Single submitter ⚠
p.Val921Met Single submitter ⚠
p.Val940Met Single submitter ⚠