NAALAD2 — 103 ClinVar variants

All ClinVar germline NAALAD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →

6 Likely benign · 97 Uncertain significance

Full NAALAD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 93

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 65

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 28

The independent predictors disagree with each other — read with care.

All NAALAD2 variants

Likely benign 6

p.Ala599Thr Single submitter
p.Ile446= Single submitter
p.Ile641Thr Single submitter
p.Ile666= Single submitter
p.Leu564Arg Single submitter
p.Lys638Arg Single submitter

Uncertain significance 97

p.Ala207Val Single submitter ⚠
p.Ala222Asp Single submitter ⚠
p.Ala242Thr Single submitter ⚠
p.Ala709Val Single submitter ⚠
p.Arg171Cys Single submitter ⚠
p.Arg171His Single submitter ⚠
p.Arg171Leu Single submitter
p.Arg297Cys Single submitter ⚠
p.Arg368Pro Single submitter ⚠
p.Arg42Cys Single submitter ⚠
p.Arg42His Single submitter ⚠
p.Arg48Gln Single submitter ⚠
p.Arg663Ile Single submitter ⚠
p.Arg7Pro Single submitter ⚠
p.Asn146Asp Single submitter ⚠
p.Asn146Tyr Single submitter ⚠
p.Asn347Asp Single submitter ⚠
p.Asn347Ser Single submitter ⚠
p.Asn428Lys Single submitter ⚠
p.Asp163His Single submitter ⚠
p.Asp256Glu Single submitter ⚠
p.Asp609Glu Single submitter ⚠
p.Asp700Asn Single submitter ⚠
p.Gln157Arg Single submitter ⚠
p.Gln563Lys Single submitter ⚠
p.Gln89Glu Single submitter ⚠
p.Glu127Gln Single submitter ⚠
p.Glu275Gln Single submitter ⚠
p.Glu434Lys Single submitter ⚠
p.Glu553Gly Single submitter ⚠
p.Gly140Asp Single submitter ⚠
p.Gly158Asp Single submitter ⚠
p.Gly183Asp Single submitter ⚠
p.Gly240Ala Single submitter ⚠
p.Gly301Val Single submitter ⚠
p.Gly320Arg Single submitter ⚠
p.Gly325Val Single submitter ⚠
p.Gly506Val Single submitter ⚠
p.Gly6Ser Single submitter ⚠
p.Gly734Arg Single submitter ⚠
p.His44Tyr Single submitter ⚠
p.Ile213Met Single submitter ⚠
p.Ile216Thr Single submitter ⚠
p.Ile471Ser Single submitter
p.Ile47Thr Single submitter ⚠
p.Ile601Val Single submitter ⚠
p.Ile60Thr Single submitter
p.Ile681Val Single submitter ⚠
p.Ile705Thr Single submitter ⚠
p.Leu22Pro Single submitter ⚠
p.Leu459Phe Single submitter ⚠
p.Leu483Gln Single submitter ⚠
p.Leu604Val Single submitter ⚠
p.Leu70Phe Single submitter ⚠
p.Leu740Ser Single submitter ⚠
p.Leu8Pro Single submitter ⚠
p.Lys398Asn Single submitter ⚠
p.Lys430Arg Single submitter ⚠
p.Lys607Arg Single submitter ⚠
p.Lys638Glu Single submitter ⚠
p.Lys716Arg Single submitter ⚠
p.Met159Val Single submitter ⚠
p.Met334Val Single submitter ⚠
p.Phe199Ser Single submitter ⚠
p.Phe373Leu Single submitter ⚠
p.Phe703Leu Single submitter ⚠
p.Phe727Ser Single submitter ⚠
p.Phe93Ser Single submitter ⚠
p.Pro110His Single submitter ⚠
p.Pro160Thr Single submitter ⚠
p.Pro263Ala Single submitter ⚠
p.Pro280Ser Single submitter ⚠
p.Pro358Ser Single submitter ⚠
p.Pro378Ala Single submitter ⚠
p.Pro458Ser Single submitter ⚠
p.Pro584Ser Single submitter ⚠
p.Pro668Leu Single submitter ⚠
p.Ser119Leu Single submitter ⚠
p.Ser355Pro Single submitter ⚠
p.Ser391Asn Single submitter ⚠
p.Ser442Leu Single submitter ⚠
p.Ser480Gly Single submitter ⚠
p.Ser482Pro Single submitter ⚠
p.Ser4Cys Single submitter ⚠
p.Ser62Leu Single submitter ⚠
p.Thr268Ala Single submitter ⚠
p.Thr548Ala Single submitter ⚠
p.Trp236Cys Single submitter ⚠
p.Trp424Arg Single submitter ⚠
p.Tyr117Ser Single submitter ⚠
p.Tyr224Cys Single submitter ⚠
p.Tyr465Asp Single submitter
p.Tyr590Cys Single submitter ⚠
p.Tyr602Cys Single submitter ⚠
p.Tyr602His Single submitter ⚠
p.Tyr9Cys Single submitter ⚠
p.Val121Met Single submitter ⚠