NADK — 82 ClinVar variants
All ClinVar germline NADK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
4 Benign · 8 Likely benign · 70 Uncertain significance
Full NADK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NADK p.Ala266Gly Uncertain significance Single submitter
- NADK p.Ala326Val Uncertain significance Single submitter
- NADK p.Ala374Ser Uncertain significance Single submitter
- NADK p.Ala434Val Uncertain significance Single submitter
- NADK p.Arg165Gln Uncertain significance Single submitter
- NADK p.Arg243Ser Uncertain significance Single submitter
- NADK p.Arg249Gln Uncertain significance Single submitter
- NADK p.Arg411Trp Uncertain significance Single submitter
- NADK p.Arg430Gln Uncertain significance Single submitter
- NADK p.Arg63Cys Uncertain significance Single submitter
- NADK p.Asn11Tyr Uncertain significance Single submitter
- NADK p.Asn339His Uncertain significance Single submitter
- NADK p.Asp17Glu Uncertain significance Single submitter
- NADK p.Asp17His Uncertain significance Single submitter
- NADK p.Asp270His Uncertain significance Single submitter
- NADK p.Cys23Tyr Uncertain significance Single submitter
- NADK p.Gln423Arg Uncertain significance Single submitter
- NADK p.Glu247Asp Uncertain significance Single submitter
- NADK p.Gly182Glu Uncertain significance Single submitter
- NADK p.Gly250Glu Uncertain significance Single submitter
- NADK p.Gly28Ser Uncertain significance Single submitter
- NADK p.His205Tyr Uncertain significance Single submitter
- NADK p.His435Arg Uncertain significance Single submitter
- NADK p.Ile148Val Uncertain significance Single submitter
- NADK p.Lys160Arg Uncertain significance Single submitter
- NADK p.Lys275Asn Uncertain significance Single submitter
- NADK p.Lys432Gln Uncertain significance Single submitter
- NADK p.Met10Thr Uncertain significance Single submitter
- NADK p.Met10Val Uncertain significance Single submitter
- NADK p.Met344Leu Uncertain significance Single submitter
- NADK p.Pro37Thr Uncertain significance Single submitter
- NADK p.Ser24Leu Uncertain significance Single submitter
- NADK p.Ser294Pro Uncertain significance Single submitter
- NADK p.Thr186Met Uncertain significance Single submitter
- NADK p.Thr377Ile Uncertain significance Single submitter
- NADK p.Thr99Met Uncertain significance Single submitter
- NADK p.Val429Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All NADK variants
Benign 4
- c.264-1872C>T Multiple submitters
- c.393+41G>T Multiple submitters
- c.263+2124C>T Single submitter
- p.Glu445_Gly446insGlu Single submitter
Likely benign 8
- c.263+2096G>A Single submitter
- c.263+2107G>A Single submitter
- c.263+2205C>A Single submitter
- c.264-1916C>T Single submitter
- p.Asn339= Single submitter
- p.Met271Thr Single submitter
- p.Thr99= Single submitter
- p.Val286= Single submitter
Uncertain significance 70
- c.263+2058C>T Single submitter
- c.263+2105T>G Single submitter
- c.263+2106C>T Single submitter
- c.263+2112A>G Single submitter
- c.263+2126G>A Single submitter
- c.263+2165G>A Single submitter
- c.264-1794C>T Single submitter
- c.264-1807G>A Single submitter
- c.264-1845C>G Single submitter
- c.264-1858G>A Single submitter
- c.264-1860C>G Single submitter
- c.264-1861G>A Single submitter
- c.264-1869T>C Single submitter
- c.264-1885T>C Single submitter
- c.264-1887G>A Single submitter
- c.264-1915G>A Single submitter
- c.264-1924G>A Single submitter
- c.393+14G>T Single submitter
- c.393+38A>T Single submitter
- c.393+47G>A Single submitter
- c.393+52G>A Single submitter
- c.393+60C>G Single submitter
- c.393+61C>T Single submitter
- c.393+7G>A Single submitter
- c.394-12C>T Single submitter
- c.394-35C>T Single submitter
- c.394-48A>T Single submitter
- p.Ala266Gly Single submitter ⚠
- p.Ala326Val Single submitter ⚠
- p.Ala374Ser Single submitter ⚠
- p.Ala434Val Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg243Ser Single submitter ⚠
- p.Arg249Gln Single submitter ⚠
- p.Arg411Trp Single submitter ⚠
- p.Arg430Gln Single submitter ⚠
- p.Arg63Cys Single submitter ⚠
- p.Asn11Tyr Single submitter ⚠
- p.Asn339His Single submitter ⚠
- p.Asp17Glu Single submitter ⚠
- p.Asp17His Single submitter ⚠
- p.Asp270His Single submitter ⚠
- p.Cys23Tyr Single submitter ⚠
- p.Gln423Arg Single submitter ⚠
- p.Glu247Asp Single submitter ⚠
- p.Gly182Glu Single submitter ⚠
- p.Gly250Glu Single submitter ⚠
- p.Gly28Ser Single submitter ⚠
- p.His205Tyr Single submitter ⚠
- p.His435Arg Single submitter ⚠
- p.Ile148Val Single submitter ⚠
- p.Lys160Arg Single submitter ⚠
- p.Lys275Asn Single submitter ⚠
- p.Lys432Gln Single submitter ⚠
- p.Met10Thr Single submitter ⚠
- p.Met10Val Single submitter ⚠
- p.Met335Val Single submitter
- p.Met344Leu Single submitter ⚠
- p.Phe382Leu Single submitter ⚠
- p.Pro292Ser Single submitter ⚠
- p.Pro37Thr Single submitter ⚠
- p.Ser24Leu Single submitter ⚠
- p.Ser294Pro Single submitter ⚠
- p.Ser407Phe Single submitter ⚠
- p.Ser64Cys Single submitter ⚠
- p.Ser95Arg Single submitter ⚠
- p.Thr186Met Single submitter ⚠
- p.Thr377Ile Single submitter ⚠
- p.Thr99Met Single submitter ⚠
- p.Val429Ile Single submitter ⚠