NAMPT — 22 ClinVar variants

All ClinVar germline NAMPT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →

4 Benign · 2 Likely benign · 16 Uncertain significance

Full NAMPT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 16

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 5

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 11

The independent predictors disagree with each other — read with care.

All NAMPT variants

Benign 4

c.1366-8T>C Multiple submitters
p.Pro333= Multiple submitters
p.Asn67= Single submitter
p.Val334= Single submitter

Likely benign 2

p.Gln305Glu Single submitter
p.Glu326Asp Single submitter

Uncertain significance 16

p.Ala7Thr Single submitter ⚠
p.Ala7Val Single submitter ⚠
p.Asp235Tyr Single submitter ⚠
p.Asp94Gly Single submitter ⚠
p.Gln268Lys Single submitter ⚠
p.Glu475Ala Single submitter ⚠
p.Glu8Gln Single submitter ⚠
p.Ile125Thr Single submitter ⚠
p.Ile227Asn Single submitter ⚠
p.Lys289Glu Single submitter ⚠
p.Lys32Arg Single submitter ⚠
p.Lys371Asn Single submitter ⚠
p.Lys447Arg Single submitter ⚠
p.Pro236Arg Single submitter ⚠
p.Val441Leu Single submitter ⚠
p.Val467Met Single submitter ⚠