NANP — 32 ClinVar variants
All ClinVar germline NANP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
2 Likely benign · 30 Uncertain significance
Full NANP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NANP p.Arg104Cys Uncertain significance Single submitter
- NANP p.Arg122Gln Uncertain significance Single submitter
- NANP p.Asp12Asn Uncertain significance Single submitter
- NANP p.Gln180Glu Uncertain significance Single submitter
- NANP p.Gln196Leu Uncertain significance Single submitter
- NANP p.Gly178Arg Uncertain significance Single submitter
- NANP p.Gly22Glu Uncertain significance Single submitter
- NANP p.Ile214Val Uncertain significance Single submitter
- NANP p.Ile47Leu Uncertain significance Single submitter
- NANP p.Ile80Thr Uncertain significance Single submitter
- NANP p.Leu203Trp Uncertain significance Single submitter
- NANP p.Lys84Glu Uncertain significance Single submitter
- NANP p.Met226Thr Uncertain significance Single submitter
- NANP p.Pro167Leu Uncertain significance Single submitter
- NANP p.Thr103Ala Uncertain significance Single submitter
- NANP p.Thr16Ser Uncertain significance Single submitter
- NANP p.Trp76Gly Uncertain significance Single submitter
- NANP p.Tyr41Cys Uncertain significance Single submitter
- NANP p.Val187Ile Uncertain significance Single submitter
- NANP p.Val222Leu Uncertain significance Single submitter
- NANP p.Val6Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- NANP p.Ala45Thr Uncertain significance Single submitter
- NANP p.Ala93Pro Uncertain significance Single submitter
- NANP p.Arg104His Uncertain significance Single submitter
- NANP p.Arg7Trp Uncertain significance Single submitter
- NANP p.Leu128Phe Uncertain significance Single submitter
- NANP p.Leu99Phe Uncertain significance Single submitter
- NANP p.Lys55Thr Uncertain significance Single submitter
- NANP p.Pro221Leu Uncertain significance Single submitter
- NANP p.Val52Leu Uncertain significance Single submitter
All NANP variants
Likely benign 2
- p.Arg161Lys Single submitter
- p.Asn65Ser Single submitter
Uncertain significance 30
- p.Ala45Thr Single submitter ⚠
- p.Ala93Pro Single submitter ⚠
- p.Arg104Cys Single submitter ⚠
- p.Arg104His Single submitter ⚠
- p.Arg122Gln Single submitter ⚠
- p.Arg7Trp Single submitter ⚠
- p.Asp12Asn Single submitter ⚠
- p.Gln180Glu Single submitter ⚠
- p.Gln196Leu Single submitter ⚠
- p.Gly178Arg Single submitter ⚠
- p.Gly22Glu Single submitter ⚠
- p.Ile214Val Single submitter ⚠
- p.Ile47Leu Single submitter ⚠
- p.Ile80Thr Single submitter ⚠
- p.Leu128Phe Single submitter ⚠
- p.Leu203Trp Single submitter ⚠
- p.Leu99Phe Single submitter ⚠
- p.Lys55Thr Single submitter ⚠
- p.Lys84Glu Single submitter ⚠
- p.Met226Thr Single submitter ⚠
- p.Pro167Leu Single submitter ⚠
- p.Pro221Leu Single submitter ⚠
- p.Thr103Ala Single submitter ⚠
- p.Thr16Ser Single submitter ⚠
- p.Trp76Gly Single submitter ⚠
- p.Tyr41Cys Single submitter ⚠
- p.Val187Ile Single submitter ⚠
- p.Val222Leu Single submitter ⚠
- p.Val52Leu Single submitter ⚠
- p.Val6Leu Single submitter ⚠