NAP1L1 — 34 ClinVar variants
All ClinVar germline NAP1L1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely benign · 33 Uncertain significance
Full NAP1L1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NAP1L1 p.Ala386Gly Uncertain significance Single submitter
- NAP1L1 p.Arg72Gly Uncertain significance Single submitter
- NAP1L1 p.Asp101Asn Uncertain significance Single submitter
- NAP1L1 p.Asp158Val Uncertain significance Single submitter
- NAP1L1 p.Gln14Glu Uncertain significance Single submitter
- NAP1L1 p.Gln37His Uncertain significance Single submitter
- NAP1L1 p.Gln9Glu Uncertain significance Single submitter
- NAP1L1 p.Ile199Thr Uncertain significance Single submitter
- NAP1L1 p.Leu146Met Uncertain significance Single submitter
- NAP1L1 p.Leu33Phe Uncertain significance Single submitter
- NAP1L1 p.Lys151Asn Uncertain significance Single submitter
- NAP1L1 p.Lys276Gln Uncertain significance Single submitter
- NAP1L1 p.Lys381Arg Uncertain significance Single submitter
- NAP1L1 p.Pro136Ala Uncertain significance Single submitter
- NAP1L1 p.Thr173Ala Uncertain significance Single submitter
- NAP1L1 p.Thr27Ala Uncertain significance Single submitter
- NAP1L1 p.Thr284Ile Uncertain significance Single submitter
- NAP1L1 p.Val73Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- NAP1L1 p.Ala321Val Uncertain significance Single submitter
- NAP1L1 p.Asn299Ser Uncertain significance Single submitter
- NAP1L1 p.Asp158Asn Uncertain significance Single submitter
- NAP1L1 p.Asp353Tyr Uncertain significance Single submitter
- NAP1L1 p.Asp376His Uncertain significance Single submitter
- NAP1L1 p.Gly310Val Uncertain significance Single submitter
- NAP1L1 p.Gly369Arg Uncertain significance Single submitter
- NAP1L1 p.Lys149Arg Uncertain significance Single submitter
- NAP1L1 p.Met43Ile Uncertain significance Single submitter
- NAP1L1 p.Pro307Ala Uncertain significance Single submitter
- NAP1L1 p.Tyr377Cys Uncertain significance Single submitter
All NAP1L1 variants
Likely benign 1
- p.Glu24= Single submitter
Uncertain significance 33
- p.Ala321Val Single submitter ⚠
- p.Ala386Gly Single submitter ⚠
- p.Arg72Gly Single submitter ⚠
- p.Asn299Ser Single submitter ⚠
- p.Asn45Ser Single submitter
- p.Asp101Asn Single submitter ⚠
- p.Asp158Asn Single submitter ⚠
- p.Asp158Val Single submitter ⚠
- p.Asp353Tyr Single submitter ⚠
- p.Asp376His Single submitter ⚠
- p.Gln14Glu Single submitter ⚠
- p.Gln37His Single submitter ⚠
- p.Gln9Glu Single submitter ⚠
- p.Gly310Val Single submitter ⚠
- p.Gly369Arg Single submitter ⚠
- p.Ile199Thr Single submitter ⚠
- p.Leu146Met Single submitter ⚠
- p.Leu172Phe Single submitter
- p.Leu33Phe Single submitter ⚠
- p.Lys149Arg Single submitter ⚠
- p.Lys151Asn Single submitter ⚠
- p.Lys276Gln Single submitter ⚠
- p.Lys381Arg Single submitter ⚠
- p.Met43Ile Single submitter ⚠
- p.Phe297fs Single submitter
- p.Pro136Ala Single submitter ⚠
- p.Pro307Ala Single submitter ⚠
- p.Thr173Ala Single submitter ⚠
- p.Thr225Ile Single submitter
- p.Thr27Ala Single submitter ⚠
- p.Thr284Ile Single submitter ⚠
- p.Tyr377Cys Single submitter ⚠
- p.Val73Ile Single submitter ⚠