NAP1L4 — 45 ClinVar variants
All ClinVar germline NAP1L4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Benign · 2 Likely benign · 42 Uncertain significance
Full NAP1L4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NAP1L4 p.Ala97Val Uncertain significance Single submitter
- NAP1L4 p.Arg330Gln Uncertain significance Single submitter
- NAP1L4 p.Arg44Gln Uncertain significance Single submitter
- NAP1L4 p.Arg93Gly Uncertain significance Single submitter
- NAP1L4 p.Asn127Asp Uncertain significance Single submitter
- NAP1L4 p.Asp301Asn Uncertain significance Single submitter
- NAP1L4 p.Asp46Glu Uncertain significance Single submitter
- NAP1L4 p.Glu126Gly Uncertain significance Single submitter
- NAP1L4 p.Glu182Asp Uncertain significance Single submitter
- NAP1L4 p.Glu303Gly Uncertain significance Single submitter
- NAP1L4 p.Glu370Lys Uncertain significance Single submitter
- NAP1L4 p.Ile166Val Uncertain significance Single submitter
- NAP1L4 p.Ile252Leu Uncertain significance Single submitter
- NAP1L4 p.Ile252Val Uncertain significance Single submitter
- NAP1L4 p.Ile56Val Uncertain significance Single submitter
- NAP1L4 p.Ile80Val Uncertain significance Single submitter
- NAP1L4 p.Lys19Thr Uncertain significance Single submitter
- NAP1L4 p.Lys61Glu Uncertain significance Single submitter
- NAP1L4 p.Lys83Arg Uncertain significance Single submitter
- NAP1L4 p.Pro11Thr Uncertain significance Single submitter
- NAP1L4 p.Pro156Arg Uncertain significance Single submitter
- NAP1L4 p.Pro329Ser Uncertain significance Single submitter
- NAP1L4 p.Ser174Asn Uncertain significance Single submitter
- NAP1L4 p.Val177Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- NAP1L4 p.Ala314Val Uncertain significance Single submitter
- NAP1L4 p.Ala40Gly Uncertain significance Single submitter
- NAP1L4 p.Arg44Leu Uncertain significance Single submitter
- NAP1L4 p.Asn286Ile Uncertain significance Single submitter
- NAP1L4 p.Asp118Gly Uncertain significance Single submitter
- NAP1L4 p.Glu358Gln Uncertain significance Single submitter
- NAP1L4 p.His209Asp Uncertain significance Single submitter
- NAP1L4 p.His209Leu Uncertain significance Single submitter
- NAP1L4 p.Met202Val Uncertain significance Single submitter
- NAP1L4 p.Phe167Leu Uncertain significance Single submitter
- NAP1L4 p.Pro201Leu Uncertain significance Single submitter
- NAP1L4 p.Ser299Phe Uncertain significance Single submitter
- NAP1L4 p.Thr150Met Uncertain significance Single submitter
- NAP1L4 p.Thr281Met Uncertain significance Single submitter
- NAP1L4 p.Tyr55Cys Uncertain significance Single submitter
All NAP1L4 variants
Benign 1
- p.Thr111= Multiple submitters
Likely benign 2
- p.Arg36Gln Single submitter
- p.Asn294Ser Single submitter
Uncertain significance 42
- p.Ala314Val Single submitter ⚠
- p.Ala40Gly Single submitter ⚠
- p.Ala97Val Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg44Gln Single submitter ⚠
- p.Arg44Leu Single submitter ⚠
- p.Arg93Gly Single submitter ⚠
- p.Asn127Asp Single submitter ⚠
- p.Asn259Ser Single submitter
- p.Asn286Ile Single submitter ⚠
- p.Asp118Gly Single submitter ⚠
- p.Asp301Asn Single submitter ⚠
- p.Asp46Glu Single submitter ⚠
- p.Glu126Gly Single submitter ⚠
- p.Glu182Asp Single submitter ⚠
- p.Glu303Gly Single submitter ⚠
- p.Glu358Gln Single submitter ⚠
- p.Glu370Lys Single submitter ⚠
- p.His209Asp Single submitter ⚠
- p.His209Leu Single submitter ⚠
- p.Ile166Val Single submitter ⚠
- p.Ile252Leu Single submitter ⚠
- p.Ile252Val Single submitter ⚠
- p.Ile56Val Single submitter ⚠
- p.Ile80Val Single submitter ⚠
- p.Lys19Thr Single submitter ⚠
- p.Lys61Glu Single submitter ⚠
- p.Lys83Arg Single submitter ⚠
- p.Met202Val Single submitter ⚠
- p.Met32Val Single submitter
- p.Phe167Leu Single submitter ⚠
- p.Pro11Thr Single submitter ⚠
- p.Pro156Arg Single submitter ⚠
- p.Pro183Leu Single submitter
- p.Pro201Leu Single submitter ⚠
- p.Pro329Ser Single submitter ⚠
- p.Ser174Asn Single submitter ⚠
- p.Ser299Phe Single submitter ⚠
- p.Thr150Met Single submitter ⚠
- p.Thr281Met Single submitter ⚠
- p.Tyr55Cys Single submitter ⚠
- p.Val177Ile Single submitter ⚠